BAA35123.1
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
lectin-like oxidized low-density lipoprotein receptor
NCBI Official Synonym Full Names
oxidized low density lipoprotein (lectin-like) receptor 1
NCBI Protein Information
oxidized low-density lipoprotein receptor 1; ox-LDL receptor 1; lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized low-density lipoprotein receptor; Lectin-like oxidized low-density lipoprotein receptor-1; oxidised low density lipoprotein (lectin-like) receptor 1
UniProt Protein Name
Oxidized low-density lipoprotein receptor 1
UniProt Synonym Protein Names
Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1
UniProt Synonym Gene Names
UniProt Entry Name
OLR1_RAT
NCBI Summary for Olr1
receptor for oxidized low-density lipoprotein that may be involved in pathogenesis of hypertension as well as atherosclerosis [RGD, Feb 2006]
UniProt Comments for Olr1
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Ref.2 Ref.4
Subunit structure: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70
By similarity.
Subcellular location: Cell membrane; Single-pass type II membrane protein
By similarity. Secreted
By similarity. Note: A secreted form also exists
By similarity.
Tissue specificity: Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells. Ref.1
Induction: By hypertension. Up-regulated by shear stress, lipopolysaccharide and TNF-alpha in cultured vascular endothelial cells. Ref.1 Ref.2
Domain: The cytoplasmic region is required for subcellular sorting on the cell surface
By similarity.The C-type lectin domain mediates the recognition and binding of oxLDL
By similarity.The Neck region contains 3 internal repeats that are only found in rodents.
Post-translational modification: N-glycosylated
By similarity.
Sequence similarities: Contains 1 C-type lectin domain.
Research Articles on Olr1
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Products associated with anti-Olr1 antibody
Pathways associated with anti-Olr1 antibody
Diseases associated with anti-Olr1 antibody
Organs/Tissues associated with anti-Olr1 antibody
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