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anti-LOX antibody :: Mouse LOX Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9200546
Western Blot (WB)
Unit / Price
0.1 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LOX, Monoclonal Antibody

★Popular Item★
 Also Known As   

LOX Antibody (Center) (Ascites)

 Product Synonym Names    Protein-lysine 6-oxidase; Lysyl oxidase; LOX
 Product Gene Name   

anti-LOX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    234-260
 OMIM    153455
 3D Structure    ModBase 3D Structure for P28300
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    624CT23.7.3
 Host    Mouse
 Species Reactivity    Human (Predicted Reactivity: Mouse, Pig, Rat)
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 Specificity    This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.
 Form/Format    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
 Function    Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have adirect role in tumor suppression.
 Cellular Location    Secreted, extracellular space.
 Tissue Location    Heart, placenta, skeletal muscle, kidney, lung and pancreas.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-LOX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LOX antibody

   The protein encoded by this gene is an extracellular
copper enzyme that initiates the crosslinking of collagens and
elastin. The enzyme catalyzes oxidative deamination of the
epsilon-amino group in certain lysine and hydroxylysine residues of
collagens and lysine residues of elastin. In addition to
crosslinking extracellular matrix proteins, the encoded protein may
have a role in tumor suppression. Defects in this gene are a cause
of autosomal recessive cutis laxa type I (CL type I). Two
transcript variants encoding different isoforms have been found for
this gene.
 Product Categories/Family for anti-LOX antibody    Cancer; Cardiovascular; Signal Transduction
 Applications Tested/Suitable for anti-LOX antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-LOX antibody    WB~~1:200~1600
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 Western Blot (WB) of anti-LOX antibody    LOX Antibody (Center)(Ascites) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the LOX antibody detected the LOX protein (arrow).
anti-LOX antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for LOX. It may not necessarily be applicable to this product.
 NCBI GI #    20149540
 NCBI GeneID    4015
 NCBI Accession #    NP_002308.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002317.5 [Other Products]
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 UniProt Primary Accession #    P28300 [Other Products]
 UniProt Secondary Accession #    Q5FWF0; B2R5Q3 [Other Products]
 UniProt Related Accession #    P28300 [Other Products]
 Molecular Weight    46944
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 NCBI Official Full Name    protein-lysine 6-oxidase isoform 1 preproprotein
 NCBI Official Synonym Full Names    lysyl oxidase
 NCBI Official Symbol    LOX [Similar Products]
 NCBI Protein Information    protein-lysine 6-oxidase
 UniProt Protein Name    Protein-lysine 6-oxidase
 UniProt Synonym Protein Names   
Lysyl oxidase
 Protein Family    Linoleate 9/13-lipoxygenase
 UniProt Gene Name    LOX [Similar Products]
 UniProt Entry Name    LYOX_HUMAN
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 NCBI Summary for LOX    The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
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 UniProt Comments for LOX    LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.

Protein type: Secreted; Secreted, signal peptide; Oxidoreductase; EC 1.4.3.13

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen; extracellular region; nucleus

Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity

Biological Process: response to drug; elastic fiber assembly; blood vessel development; extracellular matrix organization and biogenesis; collagen fibril organization; wound healing; response to steroid hormone stimulus; protein modification process; lung development

Disease: Cutis Laxa, Autosomal Recessive, Type Ia
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Product References and Citations for anti-LOX antibody

   Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18892-18897(2010)
Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
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 Research Articles on LOX    1. LOX is a novel regulator of NFATc1-driven osteoclastogenesis, independent of RANK ligand, which disrupts normal bone homeostasis leading to the formation of focal pre-metastatic lesions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LOX antibodyDiseases associated with anti-LOX antibody
 Reference Product  PubMed Publications
 LOXL1 antibody  >53 publications with LOX and LOXL1
 SRC antibody  >32 publications with LOX and SRC
 FGF2 antibody  >13 publications with LOX and FGF2
 BMP1 antibody  >7 publications with LOX and BMP1
 FBLN5 antibody  >7 publications with LOX and FBLN5
 SNAI1 antibody  >1 publications with LOX and SNAI1
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >607 publications with LOX and Inflammation
 Cardiovascular Diseases Antibodies  >589 publications with LOX and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >385 publications with LOX and Disease Models, Animal
 Necrosis Antibodies  >235 publications with LOX and Necrosis
 Heart Diseases Antibodies  >183 publications with LOX and Heart Diseases
 Brain Diseases Antibodies  >160 publications with LOX and Brain Diseases
 Neoplasms, Experimental Antibodies  >156 publications with LOX and Neoplasms, Experimental
 Hypertension Antibodies  >143 publications with LOX and Hypertension
 Fibrosis Antibodies  >133 publications with LOX and Fibrosis
 Lung Neoplasms Antibodies  >120 publications with LOX and Lung Neoplasms
Organs/Tissues associated with anti-LOX antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >734 publications with LOX and Vascular
 Muscle Antibodies  >398 publications with LOX and Muscle
 Brain Antibodies  >373 publications with LOX and Brain
 Lung Antibodies  >290 publications with LOX and Lung
 Heart Antibodies  >265 publications with LOX and Heart
 Liver Antibodies  >246 publications with LOX and Liver
 Bone Antibodies  >226 publications with LOX and Bone
 Skin Antibodies  >183 publications with LOX and Skin
 Kidney Antibodies  >166 publications with LOX and Kidney
 Embryonic Tissue Antibodies  >158 publications with LOX and Embryonic Tissue
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