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anti-LRP1 antibody :: Mouse anti-Human LRP1 / CD91 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245241
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LRP1 / CD91, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal (IgG1) to Human LRP1 / CD91

 Product Synonym Names    Anti-LRP1 / CD91 Antibody IHC-plus; LRP1; Apolipoprotein E receptor; CD91 antigen; CD91; A2MR; IGFBP3R; Alpha-2-macroglobulin receptor; TGFBR5; Type V tgf-beta receptor; APOER; APR; LRP; LRP-1; Human LRP1; CD91
 Product Gene Name   

anti-LRP1 antibody

[Similar Products]
 Product Synonym Gene Name    CD91 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107770
 3D Structure    ModBase 3D Structure for Q07954
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human CD91, a type I membrane protein which is also known as the alpha 2 macroglobulin receptor (alpha 2 MR). Recognizes an epitope in the extracellular region of the 500kD alpha chain.
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Purified alpha 2 macroglobulin receptor.
 Immunogen    LRP1 / CD91 antibody was raised against purified alpha 2 macroglobulin receptor.
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 Preparation and Storage    Long term: Add glycerol (40-50%) -20 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-LRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LRP1 antibody

   The low-density lipoprotein receptor related protein 1 (LRP1) is a cell surface protein highly expressed in liver that has close structural and biochemical similarities to the LDL receptor. LRP1 strongly binds calcium and mediates the clearance of chylomicron remnants from the plasma. LPR1 was also separately cloned as the alpha-2-macroglobulin receptor (A2MR) and is necessary for the A2M mediated clearance of beta-amyloid 40 and 42 via receptor-mediated endocytosis.
 Applications Tested/Suitable for anti-LRP1 antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-LRP1 antibody    ELISA, Flo, IHC-Fr, IHC-P (5 - 10 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-LRP1 antibody    Anti-LRP1 / Low Density LRP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-LRP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LRP1. It may not necessarily be applicable to this product.
 NCBI GI #    126012562
 NCBI GeneID    4035
 NCBI Accession #    NP_002323.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002332.2 [Other Products]
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 UniProt Primary Accession #    Q07954 [Other Products]
 UniProt Secondary Accession #    Q2PP12; Q86SW0; Q8IVG8 [Other Products]
 UniProt Related Accession #    Q07954 [Other Products]
 Molecular Weight    31,631 Da
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 NCBI Official Full Name    prolow-density lipoprotein receptor-related protein 1
 NCBI Official Synonym Full Names    low density lipoprotein receptor-related protein 1
 NCBI Official Symbol    LRP1 [Similar Products]
 NCBI Official Synonym Symbols   
APR; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
[Similar Products]
 NCBI Protein Information    prolow-density lipoprotein receptor-related protein 1; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor
 UniProt Protein Name    Prolow-density lipoprotein receptor-related protein 1
 UniProt Synonym Protein Names   
Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD_antigen: CD91Cleaved into the following 3 chains:Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; LRP-515; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRPICD
 Protein Family    Low-density lipoprotein receptor-related protein
 UniProt Gene Name    LRP1 [Similar Products]
 UniProt Synonym Gene Names    A2MR; APR; LRP-1; A2MR; APOER; LRP-85; LRP-515; LRPICD [Similar Products]
 UniProt Entry Name    LRP1_HUMAN
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 NCBI Summary for LRP1    The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
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 UniProt Comments for LRP1    LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis; Cell surface

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: focal adhesion; clathrin-coated vesicle; cell soma; integral to plasma membrane; lysosomal membrane; dendrite; cytoplasm; plasma membrane; nucleolus; coated pit; endosome; receptor complex

Molecular Function: protein binding; lipoprotein transporter activity; protease binding; protein complex binding; apolipoprotein binding; calcium ion binding; receptor activity

Biological Process: cholesterol metabolic process; phototransduction, visible light; receptor-mediated endocytosis; regulation of phospholipase A2 activity; negative regulation of Wnt receptor signaling pathway; lipoprotein metabolic process; negative regulation of smooth muscle cell migration; positive regulation of protein transport; positive regulation of lipid transport; cell proliferation; lipoprotein transport; regulation of actin cytoskeleton organization and biogenesis; protein kinase C activation; negative regulation of neuron apoptosis; regulation of cholesterol transport; retinoid metabolic process; apoptotic cell clearance; aging
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 Research Articles on LRP1    1. The molecular mechanisms involved at distinct levels in the regulation of LRP-1, from its expression to the proper location and stability at the cell surface are discussed. Review.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LRP1 antibodyDiseases associated with anti-LRP1 antibody
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PDGFR-beta Signaling Pathway antibodies  PDGFR-beta Signaling Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >102 publications with LRP1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >85 publications with LRP1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >65 publications with LRP1 and Atherosclerosis
 Inflammation Antibodies  >43 publications with LRP1 and Inflammation
 Disease Models, Animal Antibodies  >35 publications with LRP1 and Disease Models, Animal
 Necrosis Antibodies  >25 publications with LRP1 and Necrosis
 Dyslipidemias Antibodies  >17 publications with LRP1 and Dyslipidemias
 Heart Diseases Antibodies  >16 publications with LRP1 and Heart Diseases
 Liver Diseases Antibodies  >12 publications with LRP1 and Liver Diseases
 Breast Neoplasms Antibodies  >9 publications with LRP1 and Breast Neoplasms
Organs/Tissues associated with anti-LRP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >159 publications with LRP1 and Blood
 Brain Antibodies  >146 publications with LRP1 and Brain
 Vascular Antibodies  >109 publications with LRP1 and Vascular
 Muscle Antibodies  >57 publications with LRP1 and Muscle
 Liver Antibodies  >40 publications with LRP1 and Liver
 Nerve Antibodies  >33 publications with LRP1 and Nerve
 Bone Antibodies  >29 publications with LRP1 and Bone
 Heart Antibodies  >20 publications with LRP1 and Heart
 Embryonic Tissue Antibodies  >17 publications with LRP1 and Embryonic Tissue
 Connective Tissue Antibodies  >16 publications with LRP1 and Connective Tissue
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