NP_001281074.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 47 kDa Observed MW: 50kDa
NCBI Official Full Name
lupus La protein
NCBI Official Synonym Full Names
Sjogren syndrome antigen B
NCBI Protein Information
lupus La protein
UniProt Protein Name
Lupus La protein
UniProt Synonym Protein Names
La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
UniProt Synonym Gene Names
NCBI Summary for La
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
UniProt Comments for La
SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: nuclear chromosome, telomeric region; nucleus
Molecular Function: mRNA binding; protein binding; tRNA binding
Biological Process: histone mRNA metabolic process; tRNA modification
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Products associated with anti-La antibody
Pathways associated with anti-La antibody
Diseases associated with anti-La antibody
Organs/Tissues associated with anti-La antibody
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