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anti-LTF antibody :: Mouse anti-Human Lactoferrin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS584219 anti-LTF antibody
Unit / Price
0.1 mg  /  $520 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lactoferrin (LTF), Monoclonal Antibody

 Also Known As   

Lactoferrin, Human, mAb 265-1K1

 Product Gene Name   

anti-LTF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 245480
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 Clonality    Monoclonal
 Isotype    Mouse IgG1
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    1 ml (100ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
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 Preparation and Storage    Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
 Other Notes    Small volumes of anti-LTF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-LTF antibody

   Product Description: The monoclonal antibody 265-1K1 reacts with human lactoferrin (LF), an 80 kDa glycoprotein. Lactoferrin was first isolated from human milk and plays an important part in the immune system and helps to fight infections. Lactoferrin promotes the health of the gastro-intestinal system by improving the intestinal microbial balance. In addition, LF can be found in epithelia and most body fluids and secretions. Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration also represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation. Lactoferrin strongly binds to iron and this iron binding property is considered to be an important antimicrobial. Human lactoferrin binds to bacterial products through its highly positively charged N-terminus, it kills various bacteria, most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Cleavage by pepsin of lactoferrin leads to the release of lactoferricin H. This 47 amino acid peptide has more antimicrobial activity than its precursor and it can inhibit the classical but not the alternative complement pathway. Lactoferrin also plays a role in signal transduction, immunomodulation and has antiadhesive, anticancer, antiviral activity.
 Applications Tested/Suitable for anti-LTF antibody   

F, Immunoasssay (IA), Western Blot

 Application Notes for anti-LTF antibody    Application Use: For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
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NCBI/Uniprot data below describe general gene information for LTF. It may not necessarily be applicable to this product.
 NCBI GI #    2104522
 NCBI GeneID    4057
 NCBI Accession #    AAB57795.1 [Other Products]
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 UniProt Secondary Accession #    O00756; Q16780; Q16785; Q16786; Q16789; Q5DSM0; Q8IU92; A8K9U8; B2MV13; B7Z4X2; E7EQH5 [Other Products]
 UniProt Related Accession #    P02788 [Other Products]
 Molecular Weight    73,161 Da [Similar Products]
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 NCBI Official Full Name    lactoferrin, partial
 NCBI Official Synonym Full Names    lactotransferrin
 NCBI Official Symbol    LTF [Similar Products]
 NCBI Official Synonym Symbols   
LF; HLF2; GIG12; HEL110
[Similar Products]
 NCBI Protein Information    lactotransferrin; talalactoferrin; neutrophil lactoferrin; growth-inhibiting protein 12; epididymis luminal protein 110
 UniProt Protein Name    Lactotransferrin
 UniProt Synonym Protein Names   
Growth-inhibiting protein 12; TalalactoferrinCleaved into the following 5 chains:Lactoferricin-H; Lfcin-H; Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C
 Protein Family    Lactotransferrin
 UniProt Gene Name    LTF [Similar Products]
 UniProt Synonym Gene Names    GIG12; LF; Lactoferrin; Lfcin-H [Similar Products]
 UniProt Entry Name    TRFL_HUMAN
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 NCBI Summary for LTF    This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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 UniProt Comments for LTF    LTF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Belongs to the transferrin family. 2 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extracellular space; specific granule; cytoplasm; extracellular region; nucleus; secretory granule

Molecular Function: heparin binding; protein serine/threonine kinase activator activity; protein binding; ferric iron binding; DNA binding; iron ion binding; serine-type endopeptidase activity

Biological Process: interaction with host; negative regulation of lipopolysaccharide-mediated signaling pathway; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of toll-like receptor 4 signaling pathway; antifungal humoral response; proteolysis; iron ion transport; humoral immune response; regulation of cytokine production; activation of NF-kappaB transcription factor; retinal homeostasis; positive regulation of osteoblast differentiation; innate immune response in mucosa; negative regulation of viral genome replication; response to host immune response; positive regulation of osteoblast proliferation; antibacterial humoral response; regulation of tumor necrosis factor production; iron assimilation by chelation and transport; negative regulation of ATPase activity; negative regulation of viral reproduction; negative regulation of apoptosis
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 Research Articles on LTF    1. administration of lactoferrin led to autopotentiated increased expression of the LTF gene. The decreased lactoferrin mRNA levels in association with obesity and diabetes were replicated in mice adipose tissue
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Lactoferrin, Human, mAb 265-1K1
 Catalog #  Product Name  Catalog #  Product Name
 MBS570309  Mouse anti Human lactoferrin, conjugated with Horseradish peroxidase  MBS9378435  Camel Lactoferrin Antibody (Anti-LF) ELISA Kit
 MBS2047278  PE-Linked Polyclonal Antibody to Lactoferrin (LTF)  MBS022682  Rat Lactoferrin Antibody IgG ELISA Kit
 MBS145454  Human Lactoferrin (Seminal Plasma)  MBS011888  Porcine Lactoferrin Antibody IgG ELISA Kit
 MBS540529  Human Lactoferrin Antibody  MBS570306  Mouse anti Human lactoferrin
 MBS844099  Lactoferrin, Human Milk  MBS542567  Bovine Lactoferrin Antibody Western Blot Positive Control
Pathways associated with anti-LTF antibodyDiseases associated with anti-LTF antibody
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway antibodies  Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway Diagram
 Mtb Iron Assimilation By Chelation Pathway antibodies  Mtb Iron Assimilation By Chelation Pathway Diagram
 Phagosomal Maturation (early Endosomal Stage) Pathway antibodies  Phagosomal Maturation (early Endosomal Stage) Pathway Diagram
 Response Of Mtb To Phagocytosis Pathway antibodies  Response Of Mtb To Phagocytosis Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >55 publications with LTF and Nervous System Diseases
 Immune System Diseases Antibodies  >33 publications with LTF and Immune System Diseases
 Inflammation Antibodies  >26 publications with LTF and Inflammation
 Cardiovascular Diseases Antibodies  >18 publications with LTF and Cardiovascular Diseases
 Vascular Diseases Antibodies  >15 publications with LTF and Vascular Diseases
 Lung Diseases Antibodies  >14 publications with LTF and Lung Diseases
 Heart Diseases Antibodies  >9 publications with LTF and Heart Diseases
 Hypertension Antibodies  >8 publications with LTF and Hypertension
 Breast Neoplasms Antibodies  >7 publications with LTF and Breast Neoplasms
 Necrosis Antibodies  >7 publications with LTF and Necrosis
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