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anti-IGL antibody :: Mouse Lambda Light Chain Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380044
Unit / Price
0.5 mL  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lambda Light Chain (IGL), Monoclonal Antibody

★Popular Item★
 Also Known As   

Lambda Light Chain (B-Cell Marker)

 Product Synonym Names    Bence Jones Protein; BJP; IGLC 1/2/3; Mcg Marker; Paraprotein
 Product Gene Name   

anti-IGL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01701
 Clonality    Monoclonal
 Isotype    IgG2a, kappa
 Clone Number    LcN-2
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
 Form/Format    Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
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 Immunogen    Purified human IgG
 Cellular Localization    Cell Surface, Cytoplasmic and Secreted
 Hu-chromosome Location    22q11.22
 Positive Control    293T, Raji or hPBL cells. Tonsil or Spleen
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 Preparation and Storage    Antibody with azide - store at 4 to 8 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-IGL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IGL antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for anti-IGL antibody    FC/FACS: 5ul per test per one million cells in 0.1ml or 5ul per 100ul of whole blood
IF: 1:50-1:100
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 Immunofluorescence (IF) of anti-IGL antibody    Confocal Immunofluorescent analysis of Ramos cells using AF488-labeled Lambda Light Chain Monoclonal Antibody (LcN-2) (Green). DAPI was used to stain the cell nuclei (blue).
anti-IGL antibody Immunofluorescence (IF) image
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 Immunofluorescence (IF) of anti-IGL antibody    Confocal Immunofluorescent analysis of Ramos cells using AF488-labeled Isotype Control Monoclonal Antibody (IgG2a) (Green). DAPI was used to stain the cell nuclei (blue). (Negative Control)
anti-IGL antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for IGL. It may not necessarily be applicable to this product.
 NCBI GI #    1063797053
 NCBI GeneID    449585; 3535; 3546
 NCBI Accession #    P01701.2 [Other Products]
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 UniProt Primary Accession #    P01701 [Other Products]
 UniProt Secondary Accession #    P01702; P06316; P06888; A0A075B6I5 [Other Products]
 Molecular Weight    ~22.5kDa
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 NCBI Official Full Name    Immunoglobulin lambda variable 1-51
 UniProt Protein Name    Immunoglobulin lambda variable 1-51
 UniProt Synonym Protein Names   
Ig lambda chain V-I region BL2
 UniProt Gene Name    IGLV1-51 [Similar Products]
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 UniProt Comments for IGL    V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
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Product References and Citations for anti-IGL antibody

   Campbell JP et. al. J Immunol Methods. 2013; 391(1-2):1-13.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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