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anti-LMNA antibody :: Mouse Lamin A, Cleavage Site Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS600805 anti-LMNA antibody
Unit / Price
0.1 mL  /  $525 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lamin A, Cleavage Site (LMNA), Monoclonal Antibody

 Also Known As   

Lamin A, Cleavage Site (Small Subunit)

 Product Synonym Names    Anti -Lamin A, Cleavage Site (Small Subunit)
 Product Gene Name   

anti-LMNA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (156052369..156109880). Location: 1q22
 OMIM    115200
 3D Structure    ModBase 3D Structure for P02545
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3A5
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Detects endogenous levels of the small fragment of lamin A when cleaved by caspase-6 at Asp230. It is a marker of caspase-6 activity. Detects the small fragment of lamin A/C only when cleaved at Asp230. Does not crossreact with full length lamin A (nor with lamin C). Species Crossreactivity: Mouse and rat.
 Purity/Purification    Purified
Purified.
 Form/Format    Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol, 0.02% sodium azide.
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 Immunogen    Synthetic peptide corresponding to N-terminal residues adjacent to Asp230 in human lamin A.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-LMNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-LMNA antibody

   Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization (1-3). Lamin A is cleaved by caspase-6 and serves as a marker for caspase- 6 activation. During apoptosis, the 70kD lamin A is specifically cleaved to a large (40-45kD) and a small (28kD) fragment (3,4). The cleavage of lamins results in nuclear disregulation and cell death (5,6).
 Product Categories/Family for anti-LMNA antibody    Antibodies; Abs to Nuclear Proteins
 Applications Tested/Suitable for anti-LMNA antibody   

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-LMNA antibody    Dilution: Western Blot: 1:1000 Immunocytochemistry (ABC) 1:1000 Immunocytochemistry (IF) 1:1000
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NCBI/Uniprot data below describe general gene information for LMNA. It may not necessarily be applicable to this product.
 NCBI GI #    27436946
 NCBI GeneID    4000
 NCBI Accession #    NP_733821.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_170707.3 [Other Products]
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 UniProt Primary Accession #    P02545 [Other Products]
 UniProt Secondary Accession #    P02546; Q5TCJ2; Q5TCJ3; Q969I8; Q96JA2; B4DI32; D3DVB0; E7EUI9 [Other Products]
 UniProt Related Accession #    P02545 [Other Products]
 Molecular Weight    74,139 Da [Similar Products]
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 NCBI Official Full Name    lamin isoform A
 NCBI Official Synonym Full Names    lamin A/C
 NCBI Official Symbol    LMNA [Similar Products]
 NCBI Official Synonym Symbols   
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
[Similar Products]
 NCBI Protein Information    lamin; 70 kDa lamin; prelamin-A/C; lamin A/C-like 1; renal carcinoma antigen NY-REN-32
 UniProt Protein Name    Prelamin-A/C
 UniProt Synonym Protein Names   
70 kDa lamin; Renal carcinoma antigen NY-REN-32
 Protein Family    Lamin
 UniProt Gene Name    LMNA [Similar Products]
 UniProt Synonym Gene Names    LMN1 [Similar Products]
 UniProt Entry Name    LMNA_HUMAN
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 NCBI Summary for LMNA    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
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 UniProt Comments for LMNA    lamin A/C: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: nucleoplasm; nuclear lamina; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; lamin filament; intermediate filament; nuclear speck; nuclear envelope; cytosol; nucleus

Molecular Function: protein binding; structural molecule activity

Biological Process: mitotic nuclear envelope reassembly; muscle development; apoptosis; unfolded protein response; ventricular cardiac muscle cell development; mitotic nuclear envelope disassembly; regulation of cell migration; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; sterol regulatory element binding protein nuclear translocation; mitotic cell cycle; establishment and/or maintenance of microtubule cytoskeleton polarity; cell structure disassembly during apoptosis

Disease: Heart-hand Syndrome, Slovenian Type; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Restrictive Dermopathy, Lethal; Mandibuloacral Dysplasia With Type A Lipodystrophy; Muscular Dystrophy, Congenital, Lmna-related; Charcot-marie-tooth Disease, Axonal, Type 2b1; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Lipodystrophy, Familial Partial, Type 2; Hutchinson-gilford Progeria Syndrome; Muscular Dystrophy, Limb-girdle, Type 1b; Cardiomyopathy, Dilated, 1a; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism
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 Research Articles on LMNA    1. This review suggested that there is no single explanation of how LMNA gene alterations may cause these disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LMNA antibodyPathways associated with anti-LMNA antibody
 Reference Product  PubMed Publications
 EMD antibody  >17 publications with LMNA and EMD
 LMNB1 antibody  >11 publications with LMNA and LMNB1
 LMNB2 antibody  >8 publications with LMNA and LMNB2
 SYNE1 antibody  >5 publications with LMNA and SYNE1
 CASP6 antibody  >3 publications with LMNA and CASP6
 TMPO antibody  >2 publications with LMNA and TMPO
 FOS antibody  >2 publications with LMNA and FOS
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
Diseases associated with anti-LMNA antibodyOrgans/Tissues associated with anti-LMNA antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >238 publications with LMNA and Cardiovascular Diseases
 Progeria Antibodies  >221 publications with LMNA and Progeria
 Heart Diseases Antibodies  >212 publications with LMNA and Heart Diseases
 Cardiomyopathy, Dilated Antibodies  >187 publications with LMNA and Cardiomyopathy, Dilated
 Muscular Dystrophy, Emery-Dreifuss Antibodies  >132 publications with LMNA and Muscular Dystrophy, Emery-Dreifuss
 Lipodystrophy, Familial Partial Antibodies  >125 publications with LMNA and Lipodystrophy, Familial Partial
 LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2 Antibodies  >125 publications with LMNA and LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 2
 Death, Sudden, Cardiac Antibodies  >47 publications with LMNA and Death, Sudden, Cardiac
 Muscular Dystrophies, Limb-Girdle Antibodies  >35 publications with LMNA and Muscular Dystrophies, Limb-Girdle
 Heart Block Antibodies  >32 publications with LMNA and Heart Block
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >237 publications with LMNA and Muscle
 Heart Antibodies  >164 publications with LMNA and Heart
 Skin Antibodies  >109 publications with LMNA and Skin
 Adipose Tissue Antibodies  >81 publications with LMNA and Adipose Tissue
 Blood Antibodies  >72 publications with LMNA and Blood
 Bone Antibodies  >65 publications with LMNA and Bone
 Nerve Antibodies  >47 publications with LMNA and Nerve
 Connective Tissue Antibodies  >42 publications with LMNA and Connective Tissue
 Vascular Antibodies  >37 publications with LMNA and Vascular
 Brain Antibodies  >20 publications with LMNA and Brain
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