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anti-LMNB1 antibody :: Mouse anti-Human Lamin B1 (LMNB1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2034696 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-LMNB1 antibody
Unit / Price
0.01 mg  /  $100 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $175 +1 FREE 8GB USB
0.2 mg  /  $225 +1 FREE 8GB USB
1 mg  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lamin B1 (LMNB1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Lamin B1 (LMNB1) Monoclonal Antibody

 Product Synonym Names    LMN; LMN2; LMNB
 Product Gene Name   

anti-LMNB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M34458 mRNA
 3D Structure    ModBase 3D Structure for P20700
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against LMNB1. It has been selected for its ability to recognize LMNB1 in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    500ug/ml (lot specific)
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 Buffer Formulation    PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Label    None
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Supply Chain Verification    Manufactured in an a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-LMNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-LMNB1 antibody    Control Antibody; Metabolic pathway
 Applications Tested/Suitable for anti-LMNB1 antibody   

Western Blot (WB)

 Application Notes for anti-LMNB1 antibody    Loading Control of WB.
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NCBI/Uniprot data below describe general gene information for LMNB1. It may not necessarily be applicable to this product.
 NCBI GI #    5031877
 NCBI GeneID    4001
 NCBI Accession #    NP_005564.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005573.3 [Other Products]
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 UniProt Primary Accession #    P20700 [Other Products]
 UniProt Secondary Accession #    Q3SYN7; Q96EI6; B2R6J6 [Other Products]
 UniProt Related Accession #    P20700 [Other Products]
 Molecular Weight    66,408 Da
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 NCBI Official Full Name    lamin-B1 isoform 1
 NCBI Official Synonym Full Names    lamin B1
 NCBI Official Symbol    LMNB1 [Similar Products]
 NCBI Official Synonym Symbols   
LMN; ADLD; LMN2; LMNB
[Similar Products]
 NCBI Protein Information    lamin-B1
 UniProt Protein Name    Lamin-B1
 Protein Family    Lamin
 UniProt Gene Name    LMNB1 [Similar Products]
 UniProt Synonym Gene Names    LMN2; LMNB [Similar Products]
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 NCBI Summary for LMNB1    This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for LMNB1    Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: lamin filament; membrane; nuclear envelope; nuclear inner membrane; nuclear matrix; nuclear membrane; nucleoplasm; nucleus

Molecular Function: phospholipase binding; protein binding; structural molecule activity

Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant
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 Research Articles on LMNB1    1. These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LMNB1 antibodyPathways associated with anti-LMNB1 antibody
 Reference Product  PubMed Publications
 LMNA antibody  >18 publications with LMNB1 and LMNA
 SYNE1 antibody  >1 publications with LMNB1 and SYNE1
 CDK1 antibody  >1 publications with LMNB1 and CDK1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
Diseases associated with anti-LMNB1 antibodyOrgans/Tissues associated with anti-LMNB1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with LMNB1 and Nervous System Diseases
 Pelizaeus-Merzbacher Disease Antibodies  >7 publications with LMNB1 and Pelizaeus-Merzbacher Disease
 Adenocarcinoma Antibodies  >5 publications with LMNB1 and Adenocarcinoma
 Liver Diseases Antibodies  >4 publications with LMNB1 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with LMNB1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with LMNB1 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with LMNB1 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with LMNB1 and Inflammation
 Neoplasm Metastasis Antibodies  >1 publications with LMNB1 and Neoplasm Metastasis
 Nerve Degeneration Antibodies  >1 publications with LMNB1 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with LMNB1 and Brain
 Blood Antibodies  >11 publications with LMNB1 and Blood
 Skin Antibodies  >7 publications with LMNB1 and Skin
 Muscle Antibodies  >6 publications with LMNB1 and Muscle
 Bone Antibodies  >5 publications with LMNB1 and Bone
 Liver Antibodies  >4 publications with LMNB1 and Liver
 Pancreas Antibodies  >1 publications with LMNB1 and Pancreas
 Lung Antibodies  >1 publications with LMNB1 and Lung
 Intestine Antibodies  >1 publications with LMNB1 and Intestine
 Connective Tissue Antibodies  >1 publications with LMNB1 and Connective Tissue
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