AAC37575.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lamin B1
NCBI Official Synonym Full Names
lamin B1
NCBI Protein Information
lamin-B1
UniProt Protein Name
Lamin-B1
UniProt Synonym Gene Names
UniProt Entry Name
LMNB1_HUMAN
NCBI Summary for LMNB1
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]
UniProt Comments for LMNB1
Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: nucleoplasm; nuclear membrane; membrane; lamin filament; nuclear inner membrane; nuclear envelope
Molecular Function: phospholipase binding; structural molecule activity
Biological Process: apoptosis; cell structure disassembly during apoptosis
Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant
Product References and Citations for anti-LMNB1 antibody
Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes Weaver VM (J Cell Sci,Jan 1996) PUBMED Ehrnhoefer DE et al. A quantitative method for the specific assessment of caspase-6 activity in cell culture. PLoS One 6:e27680 (2011). WB ; Mouse PUBMED Ciciarello M et al. Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells. Chromosoma 119:651-68 (2010). ICC/IF ; Mouse PUBMED Kanninen K et al. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 106:16505-10 (2009) PUBMED Hui RC et al. The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol 28:5886-98 (2008). WB ; Human PUBMED Thompson J & Winoto A During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain. J Exp Med 205:1029-36 (2008). WB ; Mouse PUBMED Hui RC et al. Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells. Mol Cancer Ther 7:670-8 (2008). WB ; Human PUBMED Sharma S & Brosh RM Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS ONE 2:e1297 (2007). WB ; Human PUBMED Ivorra C et al. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. Genes Dev 20:307-20 (2006) PUBMED Johnson MD et al. Proteome analysis of DNA damage-induced neuronal death using high throughput mass spectrometry. J Biol Chem 279:26685-97 (2004) PUBMED Machiels BM et al. Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults. J Pathol 182:197-204 (1997) PUBMED Krohne G. Lamins. Methods Cell Biol. 2004;78:573-96WB, ICC/IF, IP. Mouse, Human PMID: 15646632
Research Articles on LMNB1
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Products associated with anti-LMNB1 antibody
Pathways associated with anti-LMNB1 antibody
Diseases associated with anti-LMNB1 antibody
Organs/Tissues associated with anti-LMNB1 antibody
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