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anti-LMNB2 antibody :: Mouse Lamin B2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570089
Unit / Price
0.1 mg  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lamin B2 (LMNB2), Monoclonal Antibody

 Also Known As   

Mouse anti Lamin B2

 Product Gene Name   

anti-LMNB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (2428164..2456958, complement). Location: 19p13.3
 OMIM    150341
 3D Structure    ModBase 3D Structure for Q03252
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    LN43
 Host    Mouse
 Species Reactivity    Hamster, Human, Mouse, Swine, Xenopus, Zebrafish
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 Specificity    LN43 reacts with an epitope loCated in the C-terminal part of lamin B2.
 Form/Format    Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
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 Source Note    LN43 is a Mouse monoclonal IgG1 antibody derived by fusion of Mouse myeloma cells with spleen cells from a Mouse immunized with the detergent insoluble fraction of potoroo cell line PtK1.
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-LMNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LMNB2 antibody

   Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, ie lamin B1 and lamin B2.
 Product Categories/Family for anti-LMNB2 antibody    Nuclear proteins, Cytoskeleton
 Applications Tested/Suitable for anti-LMNB2 antibody   

Flow Cytometry (FC), Immunohistochemistry (IHC) (frozen), Western Blot (WB)

 Application Notes for anti-LMNB2 antibody    LN43 is suitable for immunohistochemistry on frozen sections, immunoblotting and flow cytometry. Optimal antibody dilution should be determined by titRation; recommended range is 1:100 - 1:200 for flow cytometry, and for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting appliCations.
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 Testing Data of anti-LMNB2 antibody    Figure 1: Immunohistochemistry on frozen sections of human kidney showing nuclear lamina staining in the ductal epithelium
anti-LMNB2 antibody Testing Data image
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 Testing Data of anti-LMNB2 antibody    Figure 2: Immunofluorescence staining of a 9 days old zebrafish embryo
anti-LMNB2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for LMNB2. It may not necessarily be applicable to this product.
 NCBI GI #    1054874
 NCBI GeneID    84823
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 UniProt Primary Accession #    Q03252 [Other Products]
 UniProt Secondary Accession #    O75292; Q14734; Q96DF6 [Other Products]
 UniProt Related Accession #    Q03252 [Other Products]
 Molecular Weight    67,689 Da [Similar Products]
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 NCBI Official Full Name    lamin B2
 NCBI Official Synonym Full Names    lamin B2
 NCBI Official Symbol    LMNB2 [Similar Products]
 NCBI Official Synonym Symbols   
LMN2; LAMB2; MGC2721
[Similar Products]
 NCBI Protein Information    lamin-B2; OTTHUMP00000198023
 UniProt Protein Name    Lamin-B2
 Protein Family    Lamin
 UniProt Gene Name    LMNB2 [Similar Products]
 UniProt Synonym Gene Names    LMN2 [Similar Products]
 UniProt Entry Name    LMNB2_HUMAN
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 NCBI Summary for LMNB2    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B2. This gene is in a head-to-tail orientation with the gene for the translocase of inner mitochondrial membrane 13 homolog gene. [provided by RefSeq]
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 UniProt Comments for LMNB2    Lamin B2: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Lamin B2 may be lost during the follicle centre stage of B-cell differentiation in humans. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: lamin filament; nuclear inner membrane

Molecular Function: structural molecule activity

Disease: Lipodystrophy, Partial, Acquired, Susceptibility To
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Product References and Citations for anti-LMNB2 antibody

   Bridger, J. M., Kill, I. R., O'Farrell, M., and Hutchison, C. J. (1993). Internal lamin structures within G1 nuclei of Human dermal fibroblasts, J Cell Sci 104, 297-306. Jenkins, H., Hölman, T., Lyon, C., Lane, B., Stick, R., and Hutchison, C. J. (1993). Nuclei that lack a lamina accumulate karyophilic proteins and assemble a nuclear matrix, J Cell Sci 106, 275-285. Hozak, P., Sasseville, A. M., Raymond, Y., and Cook, P. R. (1995). Lamin proteins form an internal nucleoskeleton as well as a peripheral lamina in Human cells, J Cell Sci 108, 635-44. Machiels, B. M., Broers, J. L., Raymond, Y., de Ley, L., Kuijpers, H. J., Caberg, N. E., and Ramaekers, F. C. (1995). Abnormal A-type lamin organization in a Human lung carcinoma cell line, Eur J Cell Biol 67, 328-35. Machiels, B. M., Zorenc, A. H., Endert, J. M., Kuijpers, H. J., van Eys, G. J., Ramaekers, F. C., and Broers, J. L. (1996). An alternative splicing product of the lamin A/C gene lacks exon 10, J Biol Chem 271, 9249-53. Machiels, B. M., Ramaekers, F. C., Kuijpers, H. J., Groenewoud, J. S., Oosterhuis, J. W., and Looijenga, L. H. (1997). Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults, J Pathol 182, 197-204. Jansen, M. P., Machiels, B. M., Hopman, A. H., Broers, J. L., Bot, F. J., Arends, J. W., Ramaekers, F. C., and Schouten, H. C. (1997). Comparison of A and B-type lamin expression in reactive lymph nodes and nodular sclerosing Hodgkin's disease, Histopathology 31, 304-12. Broers, J. L., Machiels, B. M., Kuijpers, H. J., Smedts, F., van den Kieboom, R., Raymond, Y., and Ramaekers, F. C. (1997). A- and B-type lamins are differentially expressed in normal Human tissues, Histochem Cell Biol 107, 505-17.
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 Research Articles on LMNB2    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LMNB2 antibodyDiseases associated with anti-LMNB2 antibody
 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with LMNB2 and Cardiovascular Diseases
 Insulin Resistance Antibodies  >2 publications with LMNB2 and Insulin Resistance
 Congenital Abnormalities Antibodies  >2 publications with LMNB2 and Congenital Abnormalities
 Liver Cirrhosis Antibodies  >2 publications with LMNB2 and Liver Cirrhosis
 Heart Diseases Antibodies  >2 publications with LMNB2 and Heart Diseases
 Liver Diseases Antibodies  >2 publications with LMNB2 and Liver Diseases
 Bone Diseases, Developmental Antibodies  >2 publications with LMNB2 and Bone Diseases, Developmental
 LIPODYSTROPHY, PARTIAL, ACQUIRED, SUSCEPTIBILITY TO Antibodies  >2 publications with LMNB2 and LIPODYSTROPHY, PARTIAL, ACQUIRED, SUSCEPTIBILITY TO
 Cholestasis Antibodies  >1 publications with LMNB2 and Cholestasis
 Neurodegenerative Diseases Antibodies  >1 publications with LMNB2 and Neurodegenerative Diseases
Organs/Tissues associated with anti-LMNB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with LMNB2 and Skin
 Blood Antibodies  >2 publications with LMNB2 and Blood
 Liver Antibodies  >2 publications with LMNB2 and Liver
 Bone Antibodies  >1 publications with LMNB2 and Bone
 Muscle Antibodies  >1 publications with LMNB2 and Muscle
 Kidney Antibodies  >1 publications with LMNB2 and Kidney
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