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anti-LITAF antibody :: Mouse Lipopolysaccharide-induced TNF factor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140281 anti-LITAF antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lipopolysaccharide-induced TNF factor (LITAF), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Lipopolysaccharide-induced TNF factor

 Product Synonym Names    LITAF Antibody; Lipopolysaccharide-induced TNF factor, Mouse Anti Human; Lipopolysaccharide-induced tumor necrosis factor-alpha factor; LPS-induced TNF-alpha factor; p53-induced gene 7 protein; Small integral membrane protein of lysosome/late endosome; LITAF; PIG7; SIMPLE; TP53I7; FLJ38636; MGC116698; MGC116700; MGC116701; MGC125274; MGC125275; MGC125276
 Product Gene Name   

anti-LITAF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601098
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 Clonality    Monoclonal
 Isotype    IgG1 heavy chain and kappa light chain
 Clone Number    PAT1F9AT
 Host    Mouse
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 Purity/Purification    LITAF antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile Filtered clear solution.
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 Immunogen    Anti-human LITAF mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LITAF amino acids 1-161 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-LITAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LITAF antibody

   Introduction: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. LITAF is a lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of the LITAF gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in the LITAF gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget''s disease (EMPD).
 Product Categories/Family for anti-LITAF antibody    ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
 Applications Tested/Suitable for anti-LITAF antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-LITAF antibody    LITAF antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:2000 ~ 3000. Recommended starting dilution is 1:2000.
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NCBI/Uniprot data below describe general gene information for LITAF. It may not necessarily be applicable to this product.
 NCBI GI #    210147505
 NCBI GeneID    9516
 NCBI Accession #    NP_001129944.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001136472.1 [Other Products]
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 UniProt Secondary Accession #    Q05DW0; Q9C0L6; D3DUG1; G5E9K0 [Other Products]
 UniProt Related Accession #    Q99732 [Other Products]
 Molecular Weight    15,824 Da
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 NCBI Official Full Name    lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1
 NCBI Official Synonym Full Names    lipopolysaccharide-induced TNF factor
 NCBI Official Symbol    LITAF [Similar Products]
 NCBI Official Synonym Symbols   
PIG7; SIMPLE; TP53I7
[Similar Products]
 NCBI Protein Information    lipopolysaccharide-induced tumor necrosis factor-alpha factor; LPS-induced TNF-alpha factor; lipopolysaccharide-induced TNF-alpha factor; p53-induced gene 7 protein; small integral membrane protein of lysosome/late endosome; tumor protein p53 inducible protein 7
 UniProt Protein Name    Lipopolysaccharide-induced tumor necrosis factor-alpha factor
 UniProt Synonym Protein Names   
Small integral membrane protein of lysosome/late endosome; p53-induced gene 7 protein
 Protein Family    Lipopolysaccharide-induced tumor necrosis factor-alpha factor
 UniProt Gene Name    LITAF [Similar Products]
 UniProt Synonym Gene Names    PIG7; SIMPLE; LPS-induced TNF-alpha factor [Similar Products]
 UniProt Entry Name    LITAF_HUMAN
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 NCBI Summary for LITAF    Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
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 UniProt Comments for LITAF    LITAF: Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. Interacts with NEDD4. Interacts with WWOX. Isoform 2 may interact with STAT6. By bacterial lipopolysaccharides (LPS) or p53/TP53. In monocytes by the Bacillus Calmette-Guerin (BCG). Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; cytoplasm; plasma membrane

Molecular Function: signal transducer activity; protein binding; WW domain binding

Biological Process: regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; negative regulation of NF-kappaB import into nucleus; signal transduction; regulation of cytokine production; aging

Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1c
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 Research Articles on LITAF    1. Early-onset hereditary neuropathy with liability to pressure palsy (HNPP) was associated frequently with isoleucine92valine LITAF polymorphism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LITAF antibodyDiseases associated with anti-LITAF antibody
 Reference Product  PubMed Publications
 TSG101 antibody  >3 publications with LITAF and TSG101
 NEDD4 antibody  >3 publications with LITAF and NEDD4
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >63 publications with LITAF and Necrosis
 Inflammation Antibodies  >18 publications with LITAF and Inflammation
 Death Antibodies  >7 publications with LITAF and Death
 Liver Diseases Antibodies  >5 publications with LITAF and Liver Diseases
 Hyperplasia Antibodies  >3 publications with LITAF and Hyperplasia
 Charcot-Marie-Tooth disease, Type 1C Antibodies  >3 publications with LITAF and Charcot-Marie-Tooth disease, Type 1C
 Nerve Degeneration Antibodies  >2 publications with LITAF and Nerve Degeneration
 Heart Diseases Antibodies  >2 publications with LITAF and Heart Diseases
 Brain Diseases Antibodies  >2 publications with LITAF and Brain Diseases
 Atherosclerosis Antibodies  >2 publications with LITAF and Atherosclerosis
Organs/Tissues associated with anti-LITAF antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >30 publications with LITAF and Blood
 Nerve Antibodies  >21 publications with LITAF and Nerve
 Intestine Antibodies  >17 publications with LITAF and Intestine
 Spleen Antibodies  >16 publications with LITAF and Spleen
 Muscle Antibodies  >13 publications with LITAF and Muscle
 Liver Antibodies  >11 publications with LITAF and Liver
 Heart Antibodies  >10 publications with LITAF and Heart
 Kidney Antibodies  >5 publications with LITAF and Kidney
 Bone Antibodies  >4 publications with LITAF and Bone
 Lung Antibodies  >4 publications with LITAF and Lung
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