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anti-LPL antibody :: Mouse Lipoprotein Lipase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531173 anti-LPL antibody
Unit / Price
0.05 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lipoprotein Lipase (LPL), Monoclonal Antibody

★Popular Item★
 Also Known As   

Lipoprotein Lipase antibody

 Product Synonym Names    Monoclonal Lipoprotein Lipase; Anti-Lipoprotein Lipase
 Product Gene Name   

anti-LPL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    238600
 3D Structure    ModBase 3D Structure for P06858
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    Mab-7
 Host    Mouse
 Species Reactivity    Bovine, Human
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 Specificity    Bovine lipoprotein lipase
 Purity/Purification    Protein A affinity chromatography
 Form/Format    Lyophilized. Reconstitute in 1 ml dist. water (final solution contains 0.09 % NaN3, 0.5% BSA in PBS buffer, pH 7.4)
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 Biological Significance    Lipoprotein lipase is an enzyme that hydrolyzes lipids in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into three free fatty acids and one monoacylglycerol molecule. It requires Apo-CII as a cofactor. Lipoprotein lipase is specifically found in endothelial cells lining the capillaries.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Lipoprotein lipase antibody was raised in mouse using purified bovine lipoprotein lipase as the immunogen.
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-LPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-LPL antibody

   Mouse monoclonal Lipoprotein Lipase antibody
 Product Categories/Family for anti-LPL antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-LPL antibody   

User optimized

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NCBI/Uniprot data below describe general gene information for LPL. It may not necessarily be applicable to this product.
 NCBI GI #    4557727
 NCBI GeneID    4023
 NCBI Accession #    NP_000228.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000237.2 [Other Products]
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 UniProt Primary Accession #    P06858 [Other Products]
 UniProt Secondary Accession #    Q16282; Q16283; Q96FC4; B2R5T9 [Other Products]
 UniProt Related Accession #    P06858 [Other Products]
 Molecular Weight    53,162 Da [Similar Products]
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 NCBI Official Full Name    lipoprotein lipase
 NCBI Official Synonym Full Names    lipoprotein lipase
 NCBI Official Symbol    LPL [Similar Products]
 NCBI Official Synonym Symbols   
LIPD; HDLCQ11
[Similar Products]
 NCBI Protein Information    lipoprotein lipase
 UniProt Protein Name    Lipoprotein lipase
 Protein Family    Lipoprotein
 UniProt Gene Name    LPL [Similar Products]
 UniProt Synonym Gene Names    LIPD; LPL [Similar Products]
 UniProt Entry Name    LIPL_HUMAN
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 NCBI Summary for LPL    LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LPL    LPL: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency); also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: Lipid Metabolism - glycerolipid; Membrane protein, GPI anchor; Phospholipase; EC 3.1.1.34

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface; extracellular region; plasma membrane

Molecular Function: heparin binding; triacylglycerol lipase activity; protein binding; lipoprotein lipase activity; apolipoprotein binding; phospholipase activity; triglyceride binding; receptor binding

Biological Process: response to drug; phototransduction, visible light; triacylglycerol metabolic process; phospholipid metabolic process; triacylglycerol catabolic process; lipoprotein metabolic process; triacylglycerol biosynthetic process; response to cold; retinoid metabolic process; fatty acid biosynthetic process

Disease: Hyperlipoproteinemia, Type I; Hyperlipidemia, Familial Combined
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 Research Articles on LPL    1. the clinical features and genetic analysis of three patients with severe hypertriglyceridaemia including novel mutations LPL c.464T>C (p.Leu155Pro) and APOA5 c.823C>T (p.Gln275*).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LPL antibodyPathways associated with anti-LPL antibody
 Reference Product  PubMed Publications
 APOE antibody  >327 publications with LPL and APOE
 PPARG antibody  >254 publications with LPL and PPARG
 APOB antibody  >241 publications with LPL and APOB
 APOC2 antibody  >190 publications with LPL and APOC2
 GPIHBP1 antibody  >82 publications with LPL and GPIHBP1
 APOC3 antibody  >55 publications with LPL and APOC3
 APOA1 antibody  >39 publications with LPL and APOA1
 LMF1 antibody  >29 publications with LPL and LMF1
 PPARA antibody  >13 publications with LPL and PPARA
 LRP1 antibody  >10 publications with LPL and LRP1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
Diseases associated with anti-LPL antibodyOrgans/Tissues associated with anti-LPL antibody
 Disease Name  Pubmed Publications
 Dyslipidemias Antibodies  >779 publications with LPL and Dyslipidemias
 Hyperlipidemias Antibodies  >730 publications with LPL and Hyperlipidemias
 Cardiovascular Diseases Antibodies  >676 publications with LPL and Cardiovascular Diseases
 Hypertriglyceridemia Antibodies  >571 publications with LPL and Hypertriglyceridemia
 Atherosclerosis Antibodies  >511 publications with LPL and Atherosclerosis
 Obesity Antibodies  >502 publications with LPL and Obesity
 Fatty Liver Antibodies  >323 publications with LPL and Fatty Liver
 Heart Diseases Antibodies  >300 publications with LPL and Heart Diseases
 Insulin Resistance Antibodies  >297 publications with LPL and Insulin Resistance
 Necrosis Antibodies  >175 publications with LPL and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2461 publications with LPL and Blood
 Adipose Tissue Antibodies  >1287 publications with LPL and Adipose Tissue
 Connective Tissue Antibodies  >965 publications with LPL and Connective Tissue
 Liver Antibodies  >920 publications with LPL and Liver
 Muscle Antibodies  >841 publications with LPL and Muscle
 Heart Antibodies  >656 publications with LPL and Heart
 Vascular Antibodies  >419 publications with LPL and Vascular
 Intestine Antibodies  >228 publications with LPL and Intestine
 Bone Antibodies  >192 publications with LPL and Bone
 Kidney Antibodies  >164 publications with LPL and Kidney
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