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anti-LYVE1 antibody :: Mouse Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140198 anti-LYVE1 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 (LYVE1), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1

 Product Synonym Names    LYVE1 Antibody; Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1, Mouse Anti Human; Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor; LYVE-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Hyaluronic acid receptor; Extracellular link domain-containing protein
 Product Gene Name   

anti-LYVE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605702
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 Clonality    Monoclonal
 Isotype    IgG2b heavy chain and kappa light chain
 Clone Number    P4G1AT
 Host    Mouse
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 Purity/Purification    LYVE1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
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 Immunogen    Anti-human LYVE1 mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LYVE1 amino acids 25-235 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-LYVE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LYVE1 antibody

   Introduction: LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
 Product Categories/Family for anti-LYVE1 antibody    MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme
 Applications Tested/Suitable for anti-LYVE1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-LYVE1 antibody    LYVE1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:1,000.
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NCBI/Uniprot data below describe general gene information for LYVE1. It may not necessarily be applicable to this product.
 NCBI GI #    40549451
 NCBI GeneID    10894
 NCBI Accession #    NP_006682.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006691.3 [Other Products]
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 UniProt Secondary Accession #    Q8TC18; Q9UNF4 [Other Products]
 UniProt Related Accession #    Q9Y5Y7 [Other Products]
 Molecular Weight    35,213 Da
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 NCBI Official Full Name    lymphatic vessel endothelial hyaluronic acid receptor 1
 NCBI Official Synonym Full Names    lymphatic vessel endothelial hyaluronan receptor 1
 NCBI Official Symbol    LYVE1 [Similar Products]
 NCBI Official Synonym Symbols   
HAR; XLKD1; LYVE-1; CRSBP-1
[Similar Products]
 NCBI Protein Information    lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1
 UniProt Protein Name    Lymphatic vessel endothelial hyaluronic acid receptor 1
 UniProt Synonym Protein Names   
Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor
 Protein Family    Lymphatic vessel endothelial hyaluronic acid receptor
 UniProt Gene Name    LYVE1 [Similar Products]
 UniProt Synonym Gene Names    CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1 [Similar Products]
 UniProt Entry Name    LYVE1_HUMAN
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 NCBI Summary for LYVE1    This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LYVE1    XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor activity; hyaluronic acid binding; receptor activity

Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; cell motility; signal transduction; hyaluronan metabolic process; hyaluronan catabolic process
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 Research Articles on LYVE1    1. Data indicate that detection of lymphatic vascular invasion (LVI) can be optimized by specific D2-40 or LYVE-1 staining.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LYVE1 antibodyPathways associated with anti-LYVE1 antibody
 Reference Product  PubMed Publications
 VEGFC antibody  >59 publications with LYVE1 and VEGFC
 CD44 antibody  >19 publications with LYVE1 and CD44
 STAB2 antibody  >3 publications with LYVE1 and STAB2
 IGFBP3 antibody  >2 publications with LYVE1 and IGFBP3
 ATM antibody  >1 publications with LYVE1 and ATM
 Products by Pathway  Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Defective PAPSS2 Causes SEMD-PA Pathway antibodies  Defective PAPSS2 Causes SEMD-PA Pathway Diagram
Diseases associated with anti-LYVE1 antibodyOrgans/Tissues associated with anti-LYVE1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >21 publications with LYVE1 and Inflammation
 Disease Models, Animal Antibodies  >14 publications with LYVE1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >13 publications with LYVE1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >11 publications with LYVE1 and Lung Diseases
 Necrosis Antibodies  >11 publications with LYVE1 and Necrosis
 Liver Neoplasms Antibodies  >10 publications with LYVE1 and Liver Neoplasms
 Edema Antibodies  >9 publications with LYVE1 and Edema
 Liver Diseases Antibodies  >9 publications with LYVE1 and Liver Diseases
 Fibrosis Antibodies  >5 publications with LYVE1 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >5 publications with LYVE1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >181 publications with LYVE1 and Vascular
 Eye Antibodies  >23 publications with LYVE1 and Eye
 Lung Antibodies  >21 publications with LYVE1 and Lung
 Embryonic Tissue Antibodies  >16 publications with LYVE1 and Embryonic Tissue
 Muscle Antibodies  >15 publications with LYVE1 and Muscle
 Liver Antibodies  >15 publications with LYVE1 and Liver
 Bone Antibodies  >11 publications with LYVE1 and Bone
 Stomach Antibodies  >10 publications with LYVE1 and Stomach
 Connective Tissue Antibodies  >9 publications with LYVE1 and Connective Tissue
 Heart Antibodies  >7 publications with LYVE1 and Heart
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