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anti-LOXL1 antibody :: Mouse anti-Human Lysyl Oxidase Like Protein 1 (LOXL1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2012763
Western Blot (WB)
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 Product Name   

Lysyl Oxidase Like Protein 1 (LOXL1), Monoclonal Antibody

★Popular Item★
 Also Known As   

Monoclonal Antibody to Lysyl Oxidase Like Protein 1 (LOXL1)

 Product Gene Name   

anti-LOXL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- LP DLVPDPNYVQ ASTYVQRAHL YSLRCAAEEK CLASTAYAPE ATDYDVRVLL RFPQRVKNQG TADFLPNRPR HTWEWHSCHQ HYHSMDEFSH YDLLDAATGK KVAEGHKASF CLEDSTCDFG NLKRYACTSH TQGLSPGCYD TYNADIDCQW IDITDVQPGN YILKVHVNPK YIVLESDFTN NVVRCNIHYT GRYVSATNCK IVQS
 Chromosome Location    Chromosome: 15; NC_000015.9 (74218789..74244478). Location: 15q22
 OMIM    153456
 3D Structure    ModBase 3D Structure for Q08397
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    C3
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against LOXL1. It has been selected for its ability to recognize LOXL1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    500ug/ml (lot specific)
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 UOM    2001-19
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-LOXL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LOXL1 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-LOXL1 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-LOXL1 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-LOXL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for LOXL1. It may not necessarily be applicable to this product.
 NCBI GI #    67782346
 NCBI GeneID    4016
 NCBI Accession #    NP_005567.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005576.2 [Other Products]
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 UniProt Primary Accession #    Q08397 [Other Products]
 UniProt Secondary Accession #    Q6NUL3; Q96BW7 [Other Products]
 UniProt Related Accession #    Q08397 [Other Products]
 Molecular Weight    63,110 Da
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 NCBI Official Full Name    lysyl oxidase homolog 1 preproprotein
 NCBI Official Synonym Full Names    lysyl oxidase-like 1
 NCBI Official Symbol    LOXL1 [Similar Products]
 NCBI Official Synonym Symbols   
LOL; LOXL
[Similar Products]
 NCBI Protein Information    lysyl oxidase homolog 1; lysyl oxidase-like protein 1
 UniProt Protein Name    Lysyl oxidase homolog 1
 UniProt Synonym Protein Names   
Lysyl oxidase-like protein 1
 Protein Family    Lysyl oxidase
 UniProt Gene Name    LOXL1 [Similar Products]
 UniProt Synonym Gene Names    LOXL; LOL [Similar Products]
 UniProt Entry Name    LOXL1_HUMAN
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 NCBI Summary for LOXL1    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LOXL1    LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix; Oxidoreductase; EC 1.4.3.-

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: extracellular matrix; extracellular space; acrosome; extracellular region; basement membrane

Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process: extracellular matrix organization and biogenesis; response to lipopolysaccharide; protein amino acid deamination

Disease: Exfoliation Syndrome
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 Research Articles on LOXL1    1. LOXL1 is more abundant in the deposits in the iris region and, alternatively APOE is concentrated in the PEX material accumulated in the pupillary area of the anterior lens capsule.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LOXL1 antibodyPathways associated with anti-LOXL1 antibody
 Reference Product  PubMed Publications
 FBLN5 antibody  >10 publications with LOXL1 and FBLN5
 FBN1 antibody  >2 publications with LOXL1 and FBN1
 ELN antibody  >2 publications with LOXL1 and ELN
 COL5A1 antibody  >1 publications with LOXL1 and COL5A1
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Crosslinking Of Collagen Fibrils Pathway antibodies  Crosslinking Of Collagen Fibrils Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with anti-LOXL1 antibodyOrgans/Tissues associated with anti-LOXL1 antibody
 Disease Name  Pubmed Publications
 Exfoliation Syndrome Antibodies  >78 publications with LOXL1 and Exfoliation Syndrome
 Cardiovascular Diseases Antibodies  >15 publications with LOXL1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >10 publications with LOXL1 and Disease Models, Animal
 Fibrosis Antibodies  >6 publications with LOXL1 and Fibrosis
 Nervous System Diseases Antibodies  >5 publications with LOXL1 and Nervous System Diseases
 Inflammation Antibodies  >4 publications with LOXL1 and Inflammation
 Hypertension Antibodies  >4 publications with LOXL1 and Hypertension
 Heart Diseases Antibodies  >3 publications with LOXL1 and Heart Diseases
 Urinary Bladder Neoplasms Antibodies  >3 publications with LOXL1 and Urinary Bladder Neoplasms
 Kidney Diseases Antibodies  >2 publications with LOXL1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >54 publications with LOXL1 and Eye
 Connective Tissue Antibodies  >25 publications with LOXL1 and Connective Tissue
 Vascular Antibodies  >19 publications with LOXL1 and Vascular
 Muscle Antibodies  >13 publications with LOXL1 and Muscle
 Skin Antibodies  >11 publications with LOXL1 and Skin
 Bone Antibodies  >11 publications with LOXL1 and Bone
 Nerve Antibodies  >9 publications with LOXL1 and Nerve
 Lung Antibodies  >6 publications with LOXL1 and Lung
 Kidney Antibodies  >6 publications with LOXL1 and Kidney
 Bladder Antibodies  >6 publications with LOXL1 and Bladder
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