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anti-MALT1 antibody :: Mouse anti-Human MALT1 (MALT-Lymphoma Marker) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438305
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MALT1 (MALT-Lymphoma Marker), Monoclonal Antibody

★Popular Item★
 Also Known As   

MALT1 (MALT-Lymphoma Marker) Mouse Monoclonal Antibody

 Product Synonym Names    Caspase-like protein, MALT lymphoma-associated translocation, MLT1, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase
 Product Gene Name   

anti-MALT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604860
 3D Structure    ModBase 3D Structure for Q9UDY8
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    MT1/410
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic
 Immunogen    Human MALT1 recombinant fragment (aa701-808)
 Hu-Chromosome Location    18q21.32
 Positive Control    Jurkat, Daudi or HeLa cells. Tonsil or lymphoma.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-MALT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MALT1 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-MALT1 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of anti-MALT1 antibody    Formalin-fixed, paraffin-embedded human Tonsil stained with MALT1 Monoclonal Antibody (MT1/410)
anti-MALT1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-MALT1 antibody    Western Blot Analysis of Daudi Cell Lysate using MALT1 Monoclonal Antibody (MT1/410)
anti-MALT1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MALT1. It may not necessarily be applicable to this product.
 NCBI GI #    5803078
 NCBI GeneID    10892
 NCBI Accession #    NP_006776.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006785.3 [Other Products]
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 UniProt Primary Accession #    Q9UDY8 [Other Products]
 UniProt Secondary Accession #    Q9NTB7; Q9ULX4 [Other Products]
 UniProt Related Accession #    Q9UDY8 [Other Products]
 Molecular Weight    93kDa
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 NCBI Official Full Name    mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a
 NCBI Official Synonym Full Names    MALT1 paracaspase
 NCBI Official Symbol    MALT1 [Similar Products]
 NCBI Official Synonym Symbols   
MLT; MLT1; IMD12; PCASP1
[Similar Products]
 NCBI Protein Information    mucosa-associated lymphoid tissue lymphoma translocation protein 1
 UniProt Protein Name    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
 UniProt Synonym Protein Names   
MALT lymphoma-associated translocation; Paracaspase
 Protein Family    Mucosa-associated lymphoid tissue lymphoma translocation protein
 UniProt Gene Name    MALT1 [Similar Products]
 UniProt Synonym Gene Names    MLT [Similar Products]
 UniProt Entry Name    MALT1_HUMAN
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 NCBI Summary for MALT1    This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MALT1    MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Adaptor/scaffold; Nuclear export; Apoptosis; Protease; Ligase; EC 3.4.22.-

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: cytoplasm; cytosol; nucleolus; nucleus; plasma membrane; protein complex

Molecular Function: kinase activator activity; peptidase activity; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity

Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; nuclear export; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-2 production; positive regulation of T cell activation; positive regulation of T cell cytokine production; protein oligomerization; proteolysis; regulation of apoptosis; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway

Disease: Immunodeficiency 12
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Product References and Citations for anti-MALT1 antibody

   Ye H et. al. J Pathol 2005; 205: 293-301
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 Research Articles on MALT1    1. Backbone Assignment of the MALT1 Paracaspase by Solution NMR.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MALT1 antibodyPathways associated with anti-MALT1 antibody
 Reference Product  PubMed Publications
 BCL10 antibody  >257 publications with MALT1 and BCL10
 CARD11 antibody  >98 publications with MALT1 and CARD11
 IKBKB antibody  >42 publications with MALT1 and IKBKB
 TRAF6 antibody  >22 publications with MALT1 and TRAF6
 CARD10 antibody  >17 publications with MALT1 and CARD10
 PRKCQ antibody  >11 publications with MALT1 and PRKCQ
 NFKBIA antibody  >5 publications with MALT1 and NFKBIA
 TAB2 antibody  >1 publications with MALT1 and TAB2
 UBE2N antibody  >1 publications with MALT1 and UBE2N
 UBC antibody  >1 publications with MALT1 and UBC
 Products by Pathway  Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 CLEC7A/inflammasome Pathway antibodies  CLEC7A/inflammasome Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
Diseases associated with anti-MALT1 antibodyOrgans/Tissues associated with anti-MALT1 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >180 publications with MALT1 and Chromosome Aberrations
 Lymphoma, Large B-Cell, Diffuse Antibodies  >100 publications with MALT1 and Lymphoma, Large B-Cell, Diffuse
 Inflammation Antibodies  >51 publications with MALT1 and Inflammation
 Lung Neoplasms Antibodies  >25 publications with MALT1 and Lung Neoplasms
 Necrosis Antibodies  >25 publications with MALT1 and Necrosis
 Skin Diseases Antibodies  >24 publications with MALT1 and Skin Diseases
 Lung Diseases Antibodies  >22 publications with MALT1 and Lung Diseases
 Nervous System Diseases Antibodies  >17 publications with MALT1 and Nervous System Diseases
 Skin Neoplasms Antibodies  >16 publications with MALT1 and Skin Neoplasms
 Cell Transformation, Neoplastic Antibodies  >15 publications with MALT1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >157 publications with MALT1 and Blood
 Stomach Antibodies  >92 publications with MALT1 and Stomach
 Lung Antibodies  >46 publications with MALT1 and Lung
 Lymph Node Antibodies  >20 publications with MALT1 and Lymph Node
 Intestine Antibodies  >20 publications with MALT1 and Intestine
 Bone Antibodies  >17 publications with MALT1 and Bone
 Liver Antibodies  >14 publications with MALT1 and Liver
 Eye Antibodies  >13 publications with MALT1 and Eye
 Mouth Antibodies  >10 publications with MALT1 and Mouth
 Thymus Antibodies  >10 publications with MALT1 and Thymus
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