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anti-MAML3 antibody :: Mouse MAML3 (Mastermind Like Transcriptional Coactivator 3) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380186
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAML3 (Mastermind Like Transcriptional Coactivator 3), Monoclonal Antibody

★Popular Item★
 Also Known As   

MAML3 (Mastermind Like Transcriptional Coactivator 3)

 Product Synonym Names    CAGH3; ERDA3; GDN; MAML3; Mastermind-like protein 3; TNRC3
 Product Gene Name   

anti-MAML3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q96JK9
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    MAML3/1303
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jkappa; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant human full-length MAML3 protein
 Cellular Localization    Cytoplasmic
 Hu-chromosome Location    4q28
 Positive Control    MCF-7 cells. Pancreas or Placenta. Cervix or Colon Carcinoma.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-MAML3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MAML3 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-MAML3 antibody    FC/FACS: 0.5-1ug/million cells
IF: 0.5-1ug/ml
IHC-F: 0.5-1.0ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-MAML3 antibody    Formalin-fixed, paraffin-embedded Human Pancreas stained with MAML3 Monoclonal Antibody (MAML3/1303).
anti-MAML3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MAML3 antibody    Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with MAML3 Monoclonal Antibody (MAML3/1303).
anti-MAML3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MAML3 antibody    Formalin-fixed, paraffin-embedded Human Cervical Carcinoma stained with MAML3 Monoclonal Antibody (MAML3/1303).
anti-MAML3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MAML3 antibody    Formalin-fixed, paraffin-embedded Human Placenta stained with MAML3 Monoclonal Antibody (MAML3/1303).
anti-MAML3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MAML3. It may not necessarily be applicable to this product.
 NCBI GI #    38158015
 NCBI GeneID    55534
 NCBI Accession #    NP_061187.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_018717.4 [Other Products]
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 UniProt Primary Accession #    Q96JK9 [Other Products]
 UniProt Secondary Accession #    B2RNU9; B3KVV7; E7EVW8 [Other Products]
 UniProt Related Accession #    Q96JK9 [Other Products]
 Molecular Weight    150-170kDa
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 NCBI Official Full Name    mastermind-like protein 3
 NCBI Official Synonym Full Names    mastermind like transcriptional coactivator 3
 NCBI Official Symbol    MAML3 [Similar Products]
 NCBI Official Synonym Symbols   
GDN; MAM2; CAGH3; ERDA3; MAM-2; TNRC3; mam-3
[Similar Products]
 NCBI Protein Information    mastermind-like protein 3
 UniProt Protein Name    Mastermind-like protein 3
 Protein Family    Mastermind-like protein
 UniProt Gene Name    MAML3 [Similar Products]
 UniProt Synonym Gene Names    Mam-3 [Similar Products]
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 UniProt Comments for MAML3    Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
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Product References and Citations for anti-MAML3 antibody

   Wu, L., Sun, T., Kobayashi, K., Gao, P. and Griffin, J.D. 2002. Identification of a family of mastermind-like transcriptional co-activators for mammalian Notch receptors. Mol. Cell. Biol. 22: 7688-770.
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 Research Articles on MAML3    1. PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAML3 antibodyPathways associated with anti-MAML3 antibody
 Reference Product  PubMed Publications
 MAML2 antibody  >8 publications with MAML3 and MAML2
 MAML1 antibody  >7 publications with MAML3 and MAML1
 NOTCH1 antibody  >3 publications with MAML3 and NOTCH1
 HES5 antibody  >1 publications with MAML3 and HES5
 CDK8 antibody  >1 publications with MAML3 and CDK8
 NOTCH2 antibody  >1 publications with MAML3 and NOTCH2
 NOTCH3 antibody  >1 publications with MAML3 and NOTCH3
 Products by Pathway  Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
 NOTCH2 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH2 Intracellular Domain Regulates Transcription Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with anti-MAML3 antibodyOrgans/Tissues associated with anti-MAML3 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with MAML3 and Adenocarcinoma
 Musculoskeletal Diseases Antibodies  >1 publications with MAML3 and Musculoskeletal Diseases
 Sarcoma Antibodies  >1 publications with MAML3 and Sarcoma
 Heart Defects, Congenital Antibodies  >1 publications with MAML3 and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with MAML3 and Blood
 Liver Antibodies  >3 publications with MAML3 and Liver
 Intestine Antibodies  >2 publications with MAML3 and Intestine
 Heart Antibodies  >1 publications with MAML3 and Heart
 Lung Antibodies  >1 publications with MAML3 and Lung
 Lymph Node Antibodies  >1 publications with MAML3 and Lymph Node
 Stomach Antibodies  >1 publications with MAML3 and Stomach
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