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anti-MAP2 antibody :: MAP-2 (2a + 2b) Microtubule Associated Protein 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312167 anti-MAP2 antibody
Unit / Price
0.25 mg  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP-2 (2a + 2b) Microtubule Associated Protein 2 (MAP2), Monoclonal Antibody

 Also Known As   

MAb to MAP-2 (2a + 2b)

 Product Synonym Names    Monoclonal Antibody to Microtubule Associated Protein-2 (MAP-2) (2a + 2b)
 Product Gene Name   

anti-MAP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (210288771..210598834). Location: 2q34-q35
 OMIM    157130
 3D Structure    ModBase 3D Structure for P11137
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    AP20
 Host    Host: Mouse
Source: Cell Culture
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 Specificity    MAP-2 (2a + 2b) Microtubule Associated Protein 2
Recognizes (Mr 300kDa) MAP-2 protein from bovine brain and dendrites and cell bodies of neurons. Strongly cross-reacts with MAP-2 from human, rat, mouse and chicken brains. Reacts with the high molecular
 Purity/Purification    Protein G chromatography. Fluorescein which has a maximum absorbance at 492nm and an emission maximum at 518nm has been covalently attached to Anti-MAP-2 and purified to assure optimal fluorochrome/protein (F/P) molar ratios.
 Form/Format    FITC, Liquid
 Concentration    100ug/ml (OD280nm) (lot specific)
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 Affinity Constant    Not determined
 Buffer    0.01M PBS, pH 7.4 containing 1% BSA
 Preservative    0.09% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Store (protected from light) at 2 to 8 degree C. DO NOT FREEZE!
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MAP2 antibody    Monoclonal Antibodies for Neuroscience
 Applications Tested/Suitable for anti-MAP2 antibody   

Immunohistochemistry - Formalin

 Application Notes for anti-MAP2 antibody    Can be used in protein blotting and immunohistochemistry, frozen tissues only. The suggested working dilution for immunohistochemical staining is approximately 1:500. Each laboratory should determine an optimum working titer for use in its particular appl
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NCBI/Uniprot data below describe general gene information for MAP2. It may not necessarily be applicable to this product.
 NCBI GI #    215274255
 NCBI GeneID    4133
 NCBI Accession #    P11137.4 [Other Products]
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 UniProt Primary Accession #    P11137 [Other Products]
 UniProt Secondary Accession #    Q17S04; Q99975; Q99976 [Other Products]
 UniProt Related Accession #    P11137; Q16296; Q59FX9; Q6NYC5; Q8IUX2 [Other Products]
 Molecular Weight    199,526 Da [Similar Products]
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 NCBI Official Full Name    Microtubule-associated protein 2
 NCBI Official Synonym Full Names    microtubule-associated protein 2
 NCBI Official Symbol    MAP2 [Similar Products]
 NCBI Official Synonym Symbols   
MAP2A; MAP2B; MAP2C; DKFZp686I2148
[Similar Products]
 NCBI Protein Information    microtubule-associated protein 2; MAP-2; OTTHUMP00000163915; OTTHUMP00000163916; OTTHUMP00000165185; OTTHUMP00000208143; OTTHUMP00000208144
 UniProt Protein Name    Microtubule-associated protein 2
 Protein Family    Microtubule-associated protein
 UniProt Gene Name    MAP2 [Similar Products]
 UniProt Entry Name    MAP2_HUMAN
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 NCBI Summary for MAP2    This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]
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 UniProt Comments for MAP2    Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Subcellular location: Cytoplasm › cytoskeleton

Probable.

Post-translational modification: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.9 Ref.10 Ref.11 Ref.12

Sequence similarities: Contains 3 Tau/MAP repeats.
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Product References and Citations for anti-MAP2 antibody

   • Cacares, A. et al., (1984), J. Neuroscience, 4:394.
• Peng, I. et al., (1986), J. Cell Biol., 102:252.
• Lewis, S.A. et al., (1989), Nature, 342:498
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 Research Articles on MAP2    1. Increased MAP2 expression in malignant melanoma cells significantly inhibits tumor cell growth and neoplasm invasiveness, and induces apoptosis and cell cycle arrest.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAP2 antibodyPathways associated with anti-MAP2 antibody
 Reference Product  PubMed Publications
 MARK1 antibody  >8 publications with MAP2 and MARK1
 APOE antibody  >7 publications with MAP2 and APOE
 FYN antibody  >6 publications with MAP2 and FYN
 GRB2 antibody  >2 publications with MAP2 and GRB2
 MARK4 antibody  >1 publications with MAP2 and MARK4
 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
Diseases associated with anti-MAP2 antibodyOrgans/Tissues associated with anti-MAP2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >140 publications with MAP2 and Neoplasms
 Brain Ischemia Antibodies  >131 publications with MAP2 and Brain Ischemia
 Cardiovascular Diseases Antibodies  >125 publications with MAP2 and Cardiovascular Diseases
 Mental Disorders Antibodies  >111 publications with MAP2 and Mental Disorders
 Dementia Antibodies  >96 publications with MAP2 and Dementia
 Brain Injuries Antibodies  >39 publications with MAP2 and Brain Injuries
 Carcinoma Antibodies  >30 publications with MAP2 and Carcinoma
 Glioma Antibodies  >28 publications with MAP2 and Glioma
 Schizophrenia Antibodies  >28 publications with MAP2 and Schizophrenia
 Infarction, Middle Cerebral Artery Antibodies  >25 publications with MAP2 and Infarction, Middle Cerebral Artery
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1146 publications with MAP2 and Brain
 Nerve Antibodies  >446 publications with MAP2 and Nerve
 Embryonic Tissue Antibodies  >113 publications with MAP2 and Embryonic Tissue
 Eye Antibodies  >42 publications with MAP2 and Eye
 Bone Antibodies  >39 publications with MAP2 and Bone
 Muscle Antibodies  >38 publications with MAP2 and Muscle
 Vascular Antibodies  >35 publications with MAP2 and Vascular
 Adrenal Gland Antibodies  >22 publications with MAP2 and Adrenal Gland
 Liver Antibodies  >19 publications with MAP2 and Liver
 Kidney Antibodies  >18 publications with MAP2 and Kidney
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