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anti-MAP2 antibody :: anti-Human, Mouse MAP2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475033
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAP2, Monoclonal Antibody

 Also Known As   

Anti-MAP2 (N-term) Mouse mAb

 Product Synonym Names    DKFZp686I2148; Dendrite specific MAP; DKFZp686I2148; MAP 2; MAP dendrite specific; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; Microtubule associated protein 2; Microtubule-associated protein 2; Mtap 2; MTAP2_HUMAN
 Product Gene Name   

anti-MAP2 antibody

[Similar Products]
 Product Synonym Gene Name    MAP2A; MAP2B; MAP2C [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    U01828 mRNA
 3D Structure    ModBase 3D Structure for P11137
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    1D7-B9-C8-F6
 Host    Mouse
Source: Human
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity Purified
 Form/Format    Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150mM NaCl)with 0.2%sodium azide, 0.1%BSA, 50%glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    Purified recombinant human MAP2 (N-terminus) protein fragments expressed in E Coli
 Sensitivity    This antibody detects endogenous levels of MAP2 (N-terminus) and does not cross-react with related proteins.
 Sequence Similarities    Contains 3 Tau/MAP repeats.
 Subcellular Location    Cytoplasm >cytoskeleton
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 Other Notes    Small volumes of anti-MAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MAP2 antibody

   Entrez Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
UniPort Summary Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization.They also seem to have a stiffening effect on microtubules.
 Product Categories/Family for anti-MAP2 antibody    Stem Cells; Neural Stem Cells; Neuron Restricted Lineage; Neuroscience; Cell Type Marker; Neuron marker; Dendrite marker
 Applications Tested/Suitable for anti-MAP2 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

 Application Notes for anti-MAP2 antibody    WB: 1:1000
ICC: 1:150
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 Western Blot (WB) of anti-MAP2 antibody    Western blot detection of MAP2 (N-terminus) in Mouse Brain tissue and Hela cell lysates using MAP2 (N-terminus) mouse mAb (1:1000 diluted).Predicted band size: 202KDa.Observed band size: 300KDa.
anti-MAP2 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-MAP2 antibody    Immunocytochemistry staining of Hela cells fixed with 4% Paraformaldehyde and using anti-MAP2 (N-term) mouse mAb (dilution 1:100).
anti-MAP2 antibody Immunocytochemistry (ICC) (ICC) image
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 Immunoprecipitation (IP) of anti-MAP2 antibody    Immunoprecipitation analysis of Hela cell lysates using MAP2 (N-terminus) mouse mAb.
anti-MAP2 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for MAP2. It may not necessarily be applicable to this product.
 NCBI GI #    87578394
 NCBI GeneID    4133
 NCBI Accession #    NP_001034627.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031847 [Other Products]
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 UniProt Primary Accession #    P11137 [Other Products]
 UniProt Secondary Accession #    Q17S04; Q8IUX2; Q99975; Q99976 [Other Products]
 UniProt Related Accession #    P11137 [Other Products]
 Molecular Weight    300
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 NCBI Official Full Name    microtubule-associated protein 2 isoform 5
 NCBI Official Synonym Full Names    microtubule associated protein 2
 NCBI Official Symbol    MAP2 [Similar Products]
 NCBI Official Synonym Symbols   
MAP2A; MAP2B; MAP2C
[Similar Products]
 NCBI Protein Information    microtubule-associated protein 2
 UniProt Protein Name    Microtubule-associated protein 2
 Protein Family    Microtubule-associated protein
 UniProt Gene Name    MAP2 [Similar Products]
 UniProt Synonym Gene Names    MAP-2 [Similar Products]
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 NCBI Summary for MAP2    This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
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 UniProt Comments for MAP2    MAP2: a member of the microtubule-associated protein (MAP) family. Its exact function is unknown but MAPs appear to stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Expressed at high levels in neural tissue and the prostate. Four alternatively spliced transcript variants have been reported.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: cytoplasm; microtubule associated complex; neuron projection; nucleolus

Molecular Function: microtubule binding; protein binding

Biological Process: central nervous system neuron development; dendrite morphogenesis; microtubule cytoskeleton organization and biogenesis; neurite development
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 Research Articles on MAP2    1. Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAP2 antibodyPathways associated with anti-MAP2 antibody
 Reference Product  PubMed Publications
 MBP antibody  >25 publications with MAP2 and MBP
 SRC antibody  >8 publications with MAP2 and SRC
 FYN antibody  >7 publications with MAP2 and FYN
 GRB2 antibody  >2 publications with MAP2 and GRB2
 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with anti-MAP2 antibodyOrgans/Tissues associated with anti-MAP2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >465 publications with MAP2 and Nervous System Diseases
 Brain Diseases Antibodies  >404 publications with MAP2 and Brain Diseases
 Cardiovascular Diseases Antibodies  >142 publications with MAP2 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >95 publications with MAP2 and Drug Toxicity
 Nerve Degeneration Antibodies  >67 publications with MAP2 and Nerve Degeneration
 Movement Disorders Antibodies  >37 publications with MAP2 and Movement Disorders
 Atrophy Antibodies  >26 publications with MAP2 and Atrophy
 Necrosis Antibodies  >26 publications with MAP2 and Necrosis
 Immune System Diseases Antibodies  >24 publications with MAP2 and Immune System Diseases
 Inflammation Antibodies  >24 publications with MAP2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1296 publications with MAP2 and Brain
 Nerve Antibodies  >512 publications with MAP2 and Nerve
 Embryonic Tissue Antibodies  >135 publications with MAP2 and Embryonic Tissue
 Bone Antibodies  >59 publications with MAP2 and Bone
 Eye Antibodies  >52 publications with MAP2 and Eye
 Muscle Antibodies  >42 publications with MAP2 and Muscle
 Vascular Antibodies  >40 publications with MAP2 and Vascular
 Adrenal Gland Antibodies  >22 publications with MAP2 and Adrenal Gland
 Liver Antibodies  >20 publications with MAP2 and Liver
 Connective Tissue Antibodies  >19 publications with MAP2 and Connective Tissue
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