Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow MAdCAM-1 rightarrow Monoclonal MAdCAM-1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • EFNA4 Antibody
 • CSK (Ab-364) Antibody
 • PLD2 (Phospho-Tyr169) Antibody
 • Glutamate Receptor, Ionotropic, Kainate 2 (GRIK2) ELISA Kit
 • Fumarase-Fumarate Hydratase ELISA Kit
 • beta2-Glycoprotein 1 Antibody IgA (beta2-GP1 AB IgA) ELISA Kit
 • Coagulation Factor III (F3) ELISA Kit
 • Osteopontin (OPN) ELISA Kit
 • Hedgehog Homolog, Sonic (SHH) ELISA Kit
 • Growth Differentiation Factor 3 (GDF3) ELISA Kit
 • Myogenic Differentiation Antigen (MYOD) ELISA Kit
 • Leptin Receptor (OB-R) ELISA Kit
 • Caveolin 1 (CAV1) ELISA Kit
 • Sushi,Von Willebrand Factor Type A,Egf and Pentraxin Domain ... ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MAdCAM-1 antibody :: Mouse anti-Human MAdCAM-1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS584148 anti-MAdCAM-1 antibody
Unit / Price
0.1 mg  /  $520 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MAdCAM-1, Monoclonal Antibody

 Also Known As   

MAdCAM-1, Human, mAb 314G8

 Product Gene Name   

anti-MAdCAM-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    102670
Section Bar
 Clonality    Monoclonal
 Isotype    Mouse IgG1
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Form/Format    1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS, containing 0.1% bovine serum albumin.
Section Bar
Section Bar
 Preparation and Storage    Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
 Other Notes    Small volumes of anti-MAdCAM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-MAdCAM-1 antibody

   Product Description: The monocolonal antibody 314G8 reacts with human mucosal addressin cell adhesion molecules-1 (MAdCAM-1), a key player in mediating the infiltration of leukocytes into chronically inflamed tissue. MAdCAM-1 is a cell-surface Ig superfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, a transmembrane domain and a short cytoplasmatic domain. It interacts via its N-terminal Ig domain with the lymphocyte homing receptor alpha4beta7, which plays a critical role in forming the gut-associated lymphoid system. MAdCAM-1 promotes the adhesion of T- and B cells, monocytes/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to the vascular endothelium. Mucosal addressin cell adhesion molecule-1 RNA transcripts are predominantly expressed in the small intestine, mesenteric lymph nodes, colon and spleen; and are very weakly expresssed in human pancreas and brain. The monocolonal antibody 314G8 recognizes a site in the N-terminal Ig domain of MAdCAM-1. The monoclonal antibody 314G8 detects MAdCAM-1 on venules in the spleen and small intestine. MAdCAM-1 is strongly expressed in the synovium of osteoarthritis patients, predominantly on the endothelial lining of blood vessels, but also within the vessel lumen. The monoclonal antibody 314G8 may be useful in diagnosis of inflammation in humans by monitoring the presence and levels of MAdCAM-1.
 Applications Tested/Suitable for anti-MAdCAM-1 antibody   

F, Flow Cytometry (FC/FACS), FS, Immunoassay (IA), P, Western Blot (WB)

 Application Notes for anti-MAdCAM-1 antibody    Application Use: For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For inhibition of biological activity in vitro dilutions have to be made according to the amounts of MAdCAM-1 to be inactivated.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for MAdCAM-1. It may not necessarily be applicable to this product.
 NCBI GI #    109633022
 NCBI GeneID    8174
 NCBI Accession #    NP_570116.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_130760.2 [Other Products]
Section Bar
 UniProt Secondary Accession #    O60222; O75867; Q5UGI7; A5PKV4; B2RPL9 [Other Products]
 UniProt Related Accession #    Q13477 [Other Products]
 Molecular Weight    21,247 Da
Table BarTOPTable Bar
 NCBI Official Full Name    mucosal addressin cell adhesion molecule 1 isoform a
 NCBI Official Synonym Full Names    mucosal vascular addressin cell adhesion molecule 1
 NCBI Official Symbol    MADCAM1 [Similar Products]
 NCBI Official Synonym Symbols   
MACAM1
[Similar Products]
 NCBI Protein Information    mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1
 UniProt Protein Name    Mucosal addressin cell adhesion molecule 1
 UniProt Gene Name    MADCAM1 [Similar Products]
 UniProt Synonym Gene Names    MAdCAM-1; hMAdCAM-1 [Similar Products]
 UniProt Entry Name    MADCA_HUMAN
Section Bar
 NCBI Summary for MAdCAM-1    The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for MAdCAM-1    MADCAM1: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: membrane; plasma membrane; integral to membrane

Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; cell-matrix adhesion; positive regulation of leukocyte migration; signal transduction; receptor clustering; keratinocyte differentiation; heterotypic cell-cell adhesion; immune response; leukocyte tethering or rolling; cell adhesion; aging
Table BarTOPTable Bar
 

Product References and Citations for anti-MAdCAM-1 antibody

   Leung, E et al; Bioassay detects soluble MAdCAM-1 in body fluids. Immunol Cell Biol 2004, 82: 400
Section Bar
 Research Articles on MAdCAM-1    1. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-MAdCAM-1 antibodyPathways associated with anti-MAdCAM-1 antibody
 Reference Product  PubMed Publications
 ITGA4 antibody  >49 publications with MAdCAM-1 and ITGA4
 CCL25 antibody  >9 publications with MAdCAM-1 and CCL25
 CD44 antibody  >5 publications with MAdCAM-1 and CD44
 LTBR antibody  >4 publications with MAdCAM-1 and LTBR
 NKX2-3 antibody  >3 publications with MAdCAM-1 and NKX2-3
 CXCR4 antibody  >2 publications with MAdCAM-1 and CXCR4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway antibodies  Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway Diagram
Diseases associated with anti-MAdCAM-1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >82 publications with MAdCAM-1 and Inflammation
 Necrosis Antibodies  >48 publications with MAdCAM-1 and Necrosis
 Colitis Antibodies  >46 publications with MAdCAM-1 and Colitis
 Inflammatory Bowel Diseases Antibodies  >39 publications with MAdCAM-1 and Inflammatory Bowel Diseases
 Vascular Diseases Antibodies  >33 publications with MAdCAM-1 and Vascular Diseases
 Lymphoma Antibodies  >29 publications with MAdCAM-1 and Lymphoma
 Autoimmune Diseases Antibodies  >25 publications with MAdCAM-1 and Autoimmune Diseases
 Liver Diseases Antibodies  >14 publications with MAdCAM-1 and Liver Diseases
 Atrophy Antibodies  >3 publications with MAdCAM-1 and Atrophy
 Pancreatitis Antibodies  >3 publications with MAdCAM-1 and Pancreatitis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions