NP_003918.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43255 Da
NCBI Official Full Name
methyl-CpG-binding domain protein 2 isoform 1
NCBI Official Synonym Full Names
methyl-CpG binding domain protein 2
NCBI Protein Information
methyl-CpG-binding domain protein 2
UniProt Protein Name
Methyl-CpG-binding domain protein 2
UniProt Synonym Protein Names
Demethylase; DMTase; Methyl-CpG-binding protein MBD2
UniProt Synonym Gene Names
NCBI Summary for MBD2
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for MBD2
MBD2: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. May enhance the activation of some unmethylated cAMP-responsive promoters. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 18q21.2
Cellular Component: nuclear chromatin; nucleoplasm; nucleus; protein complex
Molecular Function: methyl-CpG binding; nucleosomal DNA binding; protein binding; protein domain specific binding; satellite DNA binding
Biological Process: ATP-dependent chromatin remodeling; chromatin silencing at rDNA; methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II promoter
Product References and Citations for anti-MBD2 antibody
Hendrich B.,et al.Mol. Cell. Biol. 18:6538-6547 (1998). Hendrich B.,et al.Mamm. Genome 10:906-912 (1999). Bhattacharya S.K.,et al.Nature 397:579-583 (1999). Ng H.-H.,et al.Nat. Genet. 23:58-61 (1999). Tatematsu K.,et al.Genes Cells 5:677-688 (2000).
Research Articles on MBD2
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Products associated with anti-MBD2 antibody
Pathways associated with anti-MBD2 antibody
Diseases associated with anti-MBD2 antibody
Organs/Tissues associated with anti-MBD2 antibody
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