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anti-MBD3 antibody :: Mouse MBD3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831032 anti-MBD3 antibody
Unit / Price
0.1 mg  /  $840 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MBD3, Monoclonal Antibody

 Also Known As   

MBD3 antibody

 Product Synonym Names    Monoclonal MDB3; Anti-MDB3; MBD-3; MBD 3; methyl-CpG binding Domain Protein 3; MBD3
 Product Gene Name   

anti-MBD3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603573
 3D Structure    ModBase 3D Structure for O95983
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3A3
 Host    Mouse
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 Specificity    Human
 Purity/Purification    MBD3 antibody was affinity purified with antigen peptides
 Form/Format    Lyophilized product from 1% BSA in PBS containing 0.05% NaN3, reconstitute with 1 ml of deionised water
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 Source Note    Supernatant
 Biological Significance    Methylation at CpG dinucleotides in genomic DNA is a fundamental epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl-CpG binding domain (MBD) can bind to single methylated CpGs and most of them are involved in transcription control. So far, five vertebrate MBD proteins have been described as MBD family members: BD1, MBD2, MBD3, MBD4 and MECP2.
 Immunogen    MBD3 antibody was raised in rabit using a synthetic peptide corresponding to part of the C terminal of human MBD3 (EELARDGEAPLDKAC) as the immunogen
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at 20 degree C for long term storage
 Other Notes    Small volumes of anti-MBD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MBD3 antibody

   Human MBD3 antibody
 Product Categories/Family for anti-MBD3 antibody    DNA & RNA
 Applications Tested/Suitable for anti-MBD3 antibody   

Western Blot (WB)

 Application Notes for anti-MBD3 antibody    WB: 0.1 ug/ml
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NCBI/Uniprot data below describe general gene information for MBD3. It may not necessarily be applicable to this product.
 NCBI GI #    4505119
 NCBI GeneID    53615
 NCBI Accession #    NP_003917.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003926.5 [Other Products]
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 UniProt Primary Accession #    O95983 [Other Products]
 UniProt Secondary Accession #    Q6PIL9; Q6PJZ9; Q86XF4; A8K4B7; D6W5Z2 [Other Products]
 UniProt Related Accession #    O95983 [Other Products]
 Molecular Weight    29,014 Da
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 NCBI Official Synonym Full Names    methyl-CpG binding domain protein 3
 NCBI Official Symbol    MBD3 [Similar Products]
 NCBI Protein Information    methyl-CpG-binding domain protein 3
 UniProt Protein Name    Methyl-CpG-binding domain protein 3
 UniProt Synonym Protein Names   
Methyl-CpG-binding protein MBD3
 Protein Family    Methyl-CpG-binding domain protein
 UniProt Gene Name    MBD3 [Similar Products]
 UniProt Entry Name    MBD3_HUMAN
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 NCBI Summary for MBD3    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
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 UniProt Comments for MBD3    MBD3: methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role in histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target.

Protein type: Gene silencing; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; heterochromatin; protein complex; nuclear chromatin; cytoplasm; NuRD complex

Molecular Function: protein binding; nucleosomal DNA binding; DNA binding; methyl-CpG binding

Biological Process: tissue development; establishment and/or maintenance of chromatin architecture; methylation-dependent chromatin silencing; transcription, DNA-dependent; in utero embryonic development; ATP-dependent chromatin remodeling; negative regulation of transcription from RNA polymerase II promoter; histone acetylation
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 Research Articles on MBD3    1. Insufficient MBD3 induced by small interfering RNA (siRNA) was found to result in a global DNA hypermethylation as well as increased methylation in the promoter CpG islands (CGIs) of a number of cell cycle related genes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MBD3 antibodyPathways associated with anti-MBD3 antibody
 Reference Product  PubMed Publications
 MBD2 antibody  >71 publications with MBD3 and MBD2
 HDAC1 antibody  >19 publications with MBD3 and HDAC1
 CHD4 antibody  >9 publications with MBD3 and CHD4
 HDAC2 antibody  >9 publications with MBD3 and HDAC2
 MTA1 antibody  >8 publications with MBD3 and MTA1
 MTA2 antibody  >7 publications with MBD3 and MTA2
 CHD3 antibody  >3 publications with MBD3 and CHD3
 RBBP7 antibody  >3 publications with MBD3 and RBBP7
 RBBP4 antibody  >2 publications with MBD3 and RBBP4
 GATAD2A antibody  >2 publications with MBD3 and GATAD2A
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HDACs Deacetylate Histones Pathway antibodies  HDACs Deacetylate Histones Pathway Diagram
 RNA Polymerase I Promoter Clearance Pathway antibodies  RNA Polymerase I Promoter Clearance Pathway Diagram
 RNA Polymerase I Transcription Pathway antibodies  RNA Polymerase I Transcription Pathway Diagram
 RNA Polymerase I Transcription Initiation Pathway antibodies  RNA Polymerase I Transcription Initiation Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
Diseases associated with anti-MBD3 antibodyOrgans/Tissues associated with anti-MBD3 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >8 publications with MBD3 and Disease Models, Animal
 Nervous System Diseases Antibodies  >7 publications with MBD3 and Nervous System Diseases
 Carcinoma Antibodies  >5 publications with MBD3 and Carcinoma
 Lung Neoplasms Antibodies  >5 publications with MBD3 and Lung Neoplasms
 Inflammation Antibodies  >2 publications with MBD3 and Inflammation
 Liver Neoplasms Antibodies  >2 publications with MBD3 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with MBD3 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >2 publications with MBD3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >2 publications with MBD3 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with MBD3 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with MBD3 and Brain
 Blood Antibodies  >13 publications with MBD3 and Blood
 Skin Antibodies  >12 publications with MBD3 and Skin
 Lung Antibodies  >7 publications with MBD3 and Lung
 Liver Antibodies  >7 publications with MBD3 and Liver
 Embryonic Tissue Antibodies  >5 publications with MBD3 and Embryonic Tissue
 Nerve Antibodies  >5 publications with MBD3 and Nerve
 Testis Antibodies  >4 publications with MBD3 and Testis
 Eye Antibodies  >2 publications with MBD3 and Eye
 Connective Tissue Antibodies  >2 publications with MBD3 and Connective Tissue
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