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anti-MBP antibody :: Mouse MBP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210088 anti-MBP antibody
Unit / Price
0.25 mL  /  $405 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MBP, Monoclonal Antibody

 Also Known As   

MOUSE ANTI MBP (aa82-91)

 Product Gene Name   

anti-MBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P02687
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    10
 Host    Mouse
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 Form/Format    Ascites fluid - liquid
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 Perservative Stabilisers    0.09% Sodium Azide
 Target Species    Bovine
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-MBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MBP antibody

   Mouse anti Human MBP antibody, clone 10 recognizes the synthetic peptide 82-91 and human and bovine 45-91 but not with whole native MBP molecule (Martensen numbering). This epitope is located in the C terminal region of 82-91 and the corresponding epitope is not present (or exposed) in whole MBP. The clone was selected using synthetic human MBP peptide 82-91 for screening (Groome, N.P. et al 1985). Since this work was done a sequence error has been described in the human MBP sequence in this region (Gibson, et al. 1984). Although the clone was selected to have a high affinity for 82-91 it appears that this antibody reacts more strongly with the unnatural sequence, rather than the correct human 82-91. In consequence the antibody is not a suitable reagent for sensitive immunoassays of correct human 82-91 as was thought at the time the original paper on this antibody was published. The 91-92 phe-phe bond is believed to be cleaved by demyelinating lesions by Cathepsin D to generate peptides ending in the phe 91 which should react with this monoclonal.
 Applications Tested/Suitable for anti-MBP antibody   

Immunohistology Frozen, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-MBP antibody    Immunohistology - Frozen: Maximum Dilution: 1/100
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NCBI/Uniprot data below describe general gene information for MBP. It may not necessarily be applicable to this product.
 NCBI GI #    126796
 NCBI GeneID    618684
 NCBI Accession #    P02687.1 [Other Products]
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 UniProt Primary Accession #    P02687 [Other Products]
 UniProt Secondary Accession #    Q9BGM8; Q9TS63; Q9TSA6 [Other Products]
 UniProt Related Accession #    P02687 [Other Products]
 Molecular Weight    18,323 Da
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 NCBI Official Full Name    Myelin basic protein
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    MBP [Similar Products]
 NCBI Protein Information    myelin basic protein; 20 kDa microtubule-stabilizing protein; myelin A1 protein
 UniProt Protein Name    Myelin basic protein
 UniProt Synonym Protein Names   
20 kDa microtubule-stabilizing protein; Myelin A1 protein
 Protein Family    Myelin basic protein
 UniProt Gene Name    MBP [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    MBP_BOVIN
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 UniProt Comments for MBP    MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Cellular Component: plasma membrane; myelin sheath

Molecular Function: protein binding; structural constituent of myelin sheath
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 Research Articles on MBP    1. trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MBP antibodyOrgans/Tissues associated with anti-MBP antibody
 Products by Pathway  Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3628 publications with MBP and Blood
 Brain Antibodies  >1911 publications with MBP and Brain
 Kidney Antibodies  >267 publications with MBP and Kidney
 Muscle Antibodies  >245 publications with MBP and Muscle
 Embryonic Tissue Antibodies  >157 publications with MBP and Embryonic Tissue
 Skin Antibodies  >144 publications with MBP and Skin
 Intestine Antibodies  >94 publications with MBP and Intestine
 Ovary Antibodies  >31 publications with MBP and Ovary
 Uterus Antibodies  >8 publications with MBP and Uterus
 Uncharacterized Tissue Antibodies  >4 publications with MBP and Uncharacterized Tissue
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