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anti-MBP antibody :: Mouse anti-Human MBP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531278 anti-MBP antibody
Unit / Price
1 mg  /  $615 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MBP, Monoclonal Antibody

 Also Known As   

MBP antibody

 Product Synonym Names    Monoclonal MBP; Anti-MBP; MBP; Myelin Basic Protein; Anti MBP
 Product Gene Name   

anti-MBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P02688
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    BM15
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    MBP antibody was purified by chromatography on protein G Sepharose.
 Form/Format    PBS, pH 7.4, 0.1 % NaN3.
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 Biological Significance    Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the central nervous system (CNS). The pool of MBP in the central nervous system is very diverse, with several splice variants being expressed and a large number of post-translational modifications on the protein, which include phosphorylation, methylation, deamidation, and citrullination.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    MBP antibody was raised in mouse using 18.5 kDa isoform of MBP as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-MBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MBP antibody

   Mouse monoclonal MBP antibody
 Product Categories/Family for anti-MBP antibody    Neuroscience
 Applications Tested/Suitable for anti-MBP antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MBP. It may not necessarily be applicable to this product.
 NCBI GI #    70166270
 NCBI GeneID    24547
 NCBI Accession #    NP_001020465.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025294.1 [Other Products]
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 UniProt Primary Accession #    P02688 [Other Products]
 UniProt Secondary Accession #    Q505J1; Q8R4K6; Q9Z1J4; Q9Z1J5; Q9Z1J6 [Other Products]
 UniProt Related Accession #    P02688 [Other Products]
 Molecular Weight    17,240 Da
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 NCBI Official Full Name    myelin basic protein isoform 4
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    Mbp [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    Golli-Mbp; myelin basic protein
 UniProt Protein Name    Myelin basic protein
 Protein Family    Myelin basic protein
 UniProt Gene Name    Mbp [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    MBP_RAT
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 NCBI Summary for MBP    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MBP    MBP: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Cellular Component: compact myelin; internode region of axon; cell projection; cell soma; plasma membrane; myelin sheath

Molecular Function: protein binding; protease binding; structural constituent of myelin sheath

Biological Process: myelination; response to mercury ion; substantia nigra development; response to toxin; negative regulation of axonogenesis; response to progesterone stimulus; aging
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 Research Articles on MBP    1. Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MBP antibodyPathways associated with anti-MBP antibody
 Reference Product  PubMed Publications
 Mapk1 antibody  >55 publications with MBP and Mapk1
 Mapk3 antibody  >42 publications with MBP and Mapk3
 Prg2 antibody  >12 publications with MBP and Prg2
 Lrrk2 antibody  >5 publications with MBP and Lrrk2
 Akt1 antibody  >4 publications with MBP and Akt1
 Prkca antibody  >1 publications with MBP and Prkca
 Mbl1 antibody  >1 publications with MBP and Mbl1
 Products by Pathway  Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with anti-MBP antibodyOrgans/Tissues associated with anti-MBP antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2709 publications with MBP and Nervous System Diseases
 Demyelinating Diseases Antibodies  >1982 publications with MBP and Demyelinating Diseases
 Brain Diseases Antibodies  >1743 publications with MBP and Brain Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1197 publications with MBP and Encephalomyelitis, Autoimmune, Experimental
 Cardiovascular Diseases Antibodies  >699 publications with MBP and Cardiovascular Diseases
 Inflammation Antibodies  >501 publications with MBP and Inflammation
 Hypertension Antibodies  >416 publications with MBP and Hypertension
 Necrosis Antibodies  >263 publications with MBP and Necrosis
 Heart Diseases Antibodies  >193 publications with MBP and Heart Diseases
 Kidney Diseases Antibodies  >153 publications with MBP and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1944 publications with MBP and Brain
 Heart Antibodies  >690 publications with MBP and Heart
 Spleen Antibodies  >243 publications with MBP and Spleen
 Lung Antibodies  >219 publications with MBP and Lung
 Prostate Antibodies  >28 publications with MBP and Prostate
 Adipose Tissue Antibodies  >23 publications with MBP and Adipose Tissue
 Uncharacterized Tissue Antibodies  >4 publications with MBP and Uncharacterized Tissue
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