BAA78717.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
MD-2
NCBI Official Synonym Full Names
lymphocyte antigen 96
NCBI Protein Information
lymphocyte antigen 96; protein MD-2; myeloid differentiation protein-2
UniProt Protein Name
Lymphocyte antigen 96
UniProt Synonym Protein Names
ESOP-1; Protein MD-2
UniProt Synonym Gene Names
UniProt Entry Name
LY96_HUMAN
NCBI Summary for MD-2
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
UniProt Comments for MD-2
LY96: a secreted protein that binds to the extracellular domains of TLR2 and TLR4. Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor complex, a multi-protein complex containing at least CD14, LY96 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8q21.11
Cellular Component: extracellular space; plasma membrane; lipopolysaccharide receptor complex; endosome membrane
Molecular Function: protein binding; coreceptor activity; lipopolysaccharide receptor activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of lipopolysaccharide-mediated signaling pathway; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; cell surface receptor linked signal transduction; detection of lipopolysaccharide; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; cellular defense response; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway
Product References and Citations for anti-MD-2 antibody
1. Pugin, J et al; Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood 2004, 104: 4071 2. Daubeuf, B et al; TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol 2007, 179: 6107 3. Elson, G et al; Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria. Blood 2007, 109: 1574 4. Tissieres, P et al; Soluble MD-2 is an acute phase protein and an opsonin for Gram-negative bacteria. Blood 2008, 111: 2122
Research Articles on MD-2
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Products associated with anti-MD-2 antibody
Pathways associated with anti-MD-2 antibody
Diseases associated with anti-MD-2 antibody
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