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anti-MGLL antibody :: Mouse anti-Human MGLL Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS834212
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MGLL, Monoclonal Antibody

 Also Known As   

MGLL antibody

 Product Synonym Names    Monoclonal MGLL; Anti-MGLL; Monoglyceride lipase; MGL; Lysophospholipase homolog; Monoacylglycerol lipase; HUK5
 Product Gene Name   

anti-MGLL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609699
 3D Structure    ModBase 3D Structure for Q99685
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1A1
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    MGLL antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    Monoglyceride lipase functions together with hormone-sensitive lipase to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.
 Immunogen    MGLL antibody was raised in mouse using a full length recombinant protein of human MGLL (NP_009214) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-MGLL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MGLL antibody

   Mouse monoclonal MGLL antibody
 Product Categories/Family for anti-MGLL antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-MGLL antibody   

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-MGLL antibody    FC: 1:100
IHC: 1:150
WB: 1:2000
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 Western Blot (WB) of anti-MGLL antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant MGLL protein (Right) or empty vector (Left) detected with MGLL antibody
anti-MGLL antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MGLL antibody    Immunohistochemical analysis of MGLL protein in paraffin embedded Adenocarcinoma of Human ovary tissue using MGLL antibody
anti-MGLL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MGLL. It may not necessarily be applicable to this product.
 NCBI GI #    6005786
 NCBI GeneID    11343
 NCBI Accession #    NP_009214 [Other Products]
 NCBI GenBank Nucleotide #    NM_007283.6 [Other Products]
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 UniProt Primary Accession #    Q99685 [Other Products]
 UniProt Secondary Accession #    Q6IBG9; Q96AA5; B3KRC2; B7Z9D1 [Other Products]
 UniProt Related Accession #    Q99685 [Other Products]
 Molecular Weight    31,149 Da
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 NCBI Official Full Name    monoglyceride lipase isoform 1
 NCBI Official Synonym Full Names    monoglyceride lipase
 NCBI Official Symbol    MGLL [Similar Products]
 NCBI Official Synonym Symbols   
MGL; HUK5; MAGL; HU-K5
[Similar Products]
 NCBI Protein Information    monoglyceride lipase
 UniProt Protein Name    Monoglyceride lipase
 UniProt Synonym Protein Names   
HU-K5
 Protein Family    Monoglyceride lipase
 UniProt Gene Name    MGLL [Similar Products]
 UniProt Synonym Gene Names    MAGL [Similar Products]
 UniProt Entry Name    MGLL_HUMAN
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 NCBI Summary for MGLL    This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for MGLL    MGLL: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.

Protein type: Lipid Metabolism - glycerolipid; EC 3.1.1.23; Phospholipase

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; extrinsic to membrane; plasma membrane; synapse; cytosol

Molecular Function: protein homodimerization activity; acylglycerol lipase activity; lipid binding; lysophospholipase activity

Biological Process: platelet activation; glycerophospholipid biosynthetic process; regulation of signal transduction; regulation of axon extension; phospholipid metabolic process; regulation of inflammatory response; triacylglycerol catabolic process; arachidonic acid metabolic process; lipid metabolic process; regulation of sensory perception of pain; inflammatory response; blood coagulation; fatty acid biosynthetic process; acylglycerol catabolic process
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 Research Articles on MGLL    1. Our findings establish that MAGL promotes metastases in nasopharyngeal carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MGLL antibodyPathways associated with anti-MGLL antibody
 Reference Product  PubMed Publications
 PNPLA2 antibody  >3 publications with MGLL and PNPLA2
 LIPE antibody  >3 publications with MGLL and LIPE
 LPL antibody  >1 publications with MGLL and LPL
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of DAG And TAG Pathway antibodies  Acyl Chain Remodeling Of DAG And TAG Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Arachidonate Production From DAG Pathway antibodies  Arachidonate Production From DAG Pathway Diagram
 Effects Of PIP2 Hydrolysis Pathway antibodies  Effects Of PIP2 Hydrolysis Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
Diseases associated with anti-MGLL antibodyOrgans/Tissues associated with anti-MGLL antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with MGLL and Inflammation
 Disease Models, Animal Antibodies  >3 publications with MGLL and Disease Models, Animal
 Fatty Liver Antibodies  >3 publications with MGLL and Fatty Liver
 Death Antibodies  >3 publications with MGLL and Death
 Breast Neoplasms Antibodies  >2 publications with MGLL and Breast Neoplasms
 Liver Diseases Antibodies  >2 publications with MGLL and Liver Diseases
 Insulin Resistance Antibodies  >2 publications with MGLL and Insulin Resistance
 Cardiovascular Diseases Antibodies  >1 publications with MGLL and Cardiovascular Diseases
 Weight Gain Antibodies  >1 publications with MGLL and Weight Gain
 Weight Loss Antibodies  >1 publications with MGLL and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >5 publications with MGLL and Adipose Tissue
 Blood Antibodies  >5 publications with MGLL and Blood
 Liver Antibodies  >4 publications with MGLL and Liver
 Intestine Antibodies  >4 publications with MGLL and Intestine
 Connective Tissue Antibodies  >3 publications with MGLL and Connective Tissue
 Muscle Antibodies  >3 publications with MGLL and Muscle
 Brain Antibodies  >2 publications with MGLL and Brain
 Vascular Antibodies  >1 publications with MGLL and Vascular
 Skin Antibodies  >1 publications with MGLL and Skin
 Pancreas Antibodies  >1 publications with MGLL and Pancreas
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