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anti-MGP antibody :: Mouse anti-Human, Mouse MGP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2541327
Western Blot (WB)
Unit / Price
0.06 mL  /  $220 +1 FREE 8GB USB
0.12 mL  /  $290 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MGP, Monoclonal Antibody

 Also Known As   

MGP Monoclonal Antibody

 Product Synonym Names    Cell growth inhibiting gene 36 protein; Cell growth-inhibiting gene 36 protein; GAMMA-CARBOXYGLUTAMIC ACID PROTEIN; MATRIX; GIG36; Matrix Gla protein; MGLAP; MGP; MGP; NTI
 Product Gene Name   

anti-MGP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    154870 gene
 3D Structure
   ModBase 3D Structure for P08493
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    1A1C3
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Purity/Purification    Caprylic acid/ammonium sulfate precipitation
 Concentration    1mg/mL (lot specific)
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 Immunogen    Fusion protein of MGP
 Buffer    PBS with 0.1% sodium azide, 50% glycerol, PH7.3
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MGP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MGP antibody

   Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
 Product Categories/Family for anti-MGP antibody    Signal transduction
 Applications Tested/Suitable for anti-MGP antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-MGP antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
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 Western Blot (WB) of anti-MGP antibody    Western Blot analysis of Transfected HEK-293 cells using MGP Monoclonal Antibody at dilution of 1:1000
anti-MGP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MGP. It may not necessarily be applicable to this product.
 NCBI GI #    49574514
 NCBI GeneID    4256
 NCBI Accession #    NP_000891.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000900.4 [Other Products]
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 UniProt Primary Accession #    P08493 [Other Products]
 UniProt Secondary Accession #    Q2TU41; Q567P9; Q6ICN5; A0M8W5; B2R519; J3KMX7 [Other Products]
 UniProt Related Accession #    P08493 [Other Products]
 Molecular Weight    Calculated: 13kDa
Observed: 12kDa
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 NCBI Official Full Name    matrix Gla protein isoform 2 preproprotein
 NCBI Official Synonym Full Names    matrix Gla protein
 NCBI Official Symbol    MGP [Similar Products]
 NCBI Official Synonym Symbols   
NTI; GIG36; MGLAP
[Similar Products]
 NCBI Protein Information    matrix Gla protein
 UniProt Protein Name    Matrix Gla protein
 UniProt Synonym Protein Names   
Cell growth-inhibiting gene 36 protein
 Protein Family    Matrix Gla protein
 UniProt Gene Name    MGP [Similar Products]
 UniProt Synonym Gene Names    MGLAP; MGP [Similar Products]
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 NCBI Summary for MGP    This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
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 UniProt Comments for MGP    Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
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 Research Articles on MGP    1. This study concluded that diabetes coexisting with renal disease leads to extreme vascular calcification expressed by elevated MGP levels, resulting in higher frequency of cardiovascular disease in comparison to CKD patients without diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MGP antibodyPathways associated with anti-MGP antibody
 Reference Product  PubMed Publications
 JUN antibody  >65 publications with MGP and JUN
 BMP2 antibody  >33 publications with MGP and BMP2
 PTH antibody  >11 publications with MGP and PTH
 VEGFA antibody  >5 publications with MGP and VEGFA
 DCN antibody  >3 publications with MGP and DCN
 TGFBI antibody  >2 publications with MGP and TGFBI
 JUNB antibody  >1 publications with MGP and JUNB
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway antibodies  Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway Diagram
Diseases associated with anti-MGP antibodyOrgans/Tissues associated with anti-MGP antibody
 Disease Name  Pubmed Publications
 Vascular Calcification Antibodies  >177 publications with MGP and Vascular Calcification
 Cardiovascular Diseases Antibodies  >160 publications with MGP and Cardiovascular Diseases
 Heart Diseases Antibodies  >69 publications with MGP and Heart Diseases
 Kidney Diseases Antibodies  >67 publications with MGP and Kidney Diseases
 Disease Models, Animal Antibodies  >36 publications with MGP and Disease Models, Animal
 Nervous System Diseases Antibodies  >35 publications with MGP and Nervous System Diseases
 Inflammation Antibodies  >30 publications with MGP and Inflammation
 Carcinoma Antibodies  >21 publications with MGP and Carcinoma
 Necrosis Antibodies  >18 publications with MGP and Necrosis
 Hypertension Antibodies  >17 publications with MGP and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >260 publications with MGP and Bone
 Vascular Antibodies  >233 publications with MGP and Vascular
 Blood Antibodies  >192 publications with MGP and Blood
 Muscle Antibodies  >126 publications with MGP and Muscle
 Kidney Antibodies  >105 publications with MGP and Kidney
 Connective Tissue Antibodies  >89 publications with MGP and Connective Tissue
 Heart Antibodies  >69 publications with MGP and Heart
 Brain Antibodies  >46 publications with MGP and Brain
 Lung Antibodies  >42 publications with MGP and Lung
 Liver Antibodies  >41 publications with MGP and Liver
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