NP_000891.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated: 13kDa Observed: 12kDa
NCBI Official Full Name
matrix Gla protein isoform 2 preproprotein
NCBI Official Synonym Full Names
matrix Gla protein
NCBI Protein Information
matrix Gla protein
UniProt Protein Name
Matrix Gla protein
UniProt Synonym Protein Names
Cell growth-inhibiting gene 36 protein
UniProt Synonym Gene Names
NCBI Summary for MGP
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
UniProt Comments for MGP
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
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Products associated with anti-MGP antibody
Pathways associated with anti-MGP antibody
Diseases associated with anti-MGP antibody
Organs/Tissues associated with anti-MGP antibody
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