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anti-H2-K1 antibody :: Mouse MHC CLASS I H-2Kb Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219674 anti-H2-K1 antibody
Unit / Price
0.25 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MHC CLASS I H-2Kb (H2-K1), Monoclonal Antibody

 Also Known As   

MOUSE ANTI MOUSE MHC CLASS I H-2Kb

 Product Gene Name   

anti-H2-K1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01901
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    AF6-88.5
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 0.5mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    C57BL mouse splenocytes
Buffer Solution
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-H2-K1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-H2-K1 antibody

   Mouse anti Mouse MHC Class I H-2Kb antibody, clone AF6-88.5 recognizes the H-2Kb determinant present on all nucleated cells of mice expressing this MHC class I haplotype. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region. There are 3 major MHC class I proteins encoded by the H-2 which are H-2K, H-2L and H-2D. The H- 2K gene is part of the murine H-2 complex on chromosome 17 and there are a large number of variant alleles of this gene. Mouse anti Mouse MHC Class I H-2Kb antibody, clone AF6-88.5 does not cross react with other haplotypes.
 Applications Tested/Suitable for anti-H2-K1 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-H2-K1 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/10; Maximum Dilution: 1/20
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NCBI/Uniprot data below describe general gene information for H2-K1. It may not necessarily be applicable to this product.
 NCBI GI #    133922588
 NCBI GeneID    14972
 NCBI Accession #    NP_001001892.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001892.2 [Other Products]
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 UniProt Primary Accession #    P01901 [Other Products]
 UniProt Related Accession #    P01901; P01902; P03991; P04223; P14428 [Other Products]
 Molecular Weight    41,302 Da [Similar Products]
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 NCBI Official Full Name    H-2 class I histocompatibility antigen, K-W28 alpha chain isoform 1
 NCBI Official Synonym Full Names    histocompatibility 2, K1, K region
 NCBI Official Symbol    H2-K1 [Similar Products]
 NCBI Official Synonym Symbols   
K-f; H-2K; H2-K; H-2K(d)
[Similar Products]
 NCBI Protein Information    H-2 class I histocompatibility antigen, K-W28 alpha chain; H-2 class I histocompatibility antigen, K-B alpha chain; H-2 class I histocompatibility antigen, K-D alpha chain; H-2 class I histocompatibility antigen, K-K alpha chain; H-2 class I histocompatibility antigen, K-Q alpha chain; H-2K(B); H-2K(K); H-2K(Q); MHC H2-K transplantation antigen; MHC class I H2-K-b-alpha-2 cell surface glycoprotein; MHC class I antigen; MHC class I heavy chain H2-K; class I major histocompatibility antigen H-2Kd
 UniProt Protein Name    H-2 class I histocompatibility antigen, K-B alpha chain
 Protein Family    H-2 class I histocompatibility antigen
 UniProt Gene Name    H2-K1 [Similar Products]
 UniProt Synonym Gene Names    H2-K; H-2K(B) [Similar Products]
 UniProt Entry Name    HA1B_MOUSE
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 UniProt Comments for H2-K1    HLAC iso22: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: Golgi apparatus; cell surface; membrane; endoplasmic reticulum; integral to membrane; MHC class I protein complex; Golgi medial cisterna; external side of plasma membrane

Molecular Function: protein binding; peptide antigen binding; protein heterodimerization activity; beta-2-microglobulin binding; T cell receptor binding; peptide binding; TAP binding; receptor binding

Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of T cell mediated cytotoxicity; immune system process; defense response to bacterium; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; inner ear development; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
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 Research Articles on H2-K1    1. tissue-specific h-2K(d) transgenic mice may be valuable tools for determining the mode of induction of CD8(+) T-cell responses.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-H2-K1 antibodyDiseases associated with anti-H2-K1 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >1 publications with H2-K1 and Lung Diseases
 Inflammation Antibodies  >1 publications with H2-K1 and Inflammation
Organs/Tissues associated with anti-H2-K1 antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >2 publications with H2-K1 and Spleen
 Brain Antibodies  >1 publications with H2-K1 and Brain
 Blood Antibodies  >1 publications with H2-K1 and Blood
 Lung Antibodies  >1 publications with H2-K1 and Lung
 Embryonic Tissue Antibodies  >1 publications with H2-K1 and Embryonic Tissue
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