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anti-H2-D1 antibody :: Mouse anti-Mouse MHC Class 1, H-2Kb Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604512 anti-H2-D1 antibody
Unit / Price
0.25 mg  /  $545 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MHC Class 1, H-2Kb (H2-D1), Monoclonal Antibody

 Also Known As   

MHC Class 1, H-2Kb (MHC Class I H-2Kb, H-2 Class I Histocompatibility Antigen K-B alpha Chain, H-2K(B), H2-K1, H-2K, H2-K, H-2K(d), MGC7052, MGC184092)

 Product Synonym Names    Anti -MHC Class 1, H-2Kb (MHC Class I H-2Kb, H-2 Class I Histocompatibility Antigen K-B alpha Chain, H-2K(B), H2-K1, H-2K, H2-K, H-2K(d), MGC7052, MGC184092)
 Product Gene Name   

anti-H2-D1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000083.5 (35400039..35404442). Location: 17 B1; 17 19.09 cM
 3D Structure    ModBase 3D Structure for O19453
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    AF6-88.5
 Host    Mouse
 Species Reactivity    Mouse
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 Specificity    Recognizes the mouse MHC Class I H-2Kb antigen. Does not cross react with other haplotypes.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    Mouse MHC Class 1, H2, Kb
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-H2-D1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-H2-D1 antibody

   The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region. There are 3 major MHC class I proteins encoded by the H-2 which are H-2K, H-2L and H-2D. The H- 2K gene is part of the murine H-2 complex on chromosome 17 and there are a large number of variant alleles of this gene.
 Product Categories/Family for anti-H2-D1 antibody    Antibodies; Abs to MHC
 Applications Tested/Suitable for anti-H2-D1 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-H2-D1 antibody    Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation.
Dilution: Flow Cytometry: 1:10-1:20. Use 10ul to label 10e6 cells in 100ul.
Immunohistochemistry: Frozen
Optimal working dilutions to be determined by researcher.
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NCBI/Uniprot data below describe general gene information for H2-D1. It may not necessarily be applicable to this product.
 NCBI GI #    554241
 NCBI GeneID    14964
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 UniProt Primary Accession #    O19453 [Other Products]
 UniProt Secondary Accession #    Q9QUL2 [Other Products]
 UniProt Related Accession #    O19453; O19467; O19473; O19476; O78206; O78207; P01895; P01896; P01897; P01899 [Other Products]
 Molecular Weight    16,970 Da [Similar Products]
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 NCBI Official Full Name    MHC class I H2 antigen
 NCBI Official Synonym Full Names    histocompatibility 2, D region locus 1
 NCBI Official Symbol    H2-D1 [Similar Products]
 NCBI Official Synonym Symbols   
H-2D; H2-D
[Similar Products]
 NCBI Protein Information    H-2 class I histocompatibility antigen, L-D alpha chain; Q5k protein; MHC class I H-2Dp; MHC H2-D-q alpha-chain; MHC class I H2 antigen; H-2D cell surface glycoprotein; H2-DC1-beta transplantation antigen protein
 UniProt Protein Name    Cell surface glycoprotein
 Protein Family    H-2 class I histocompatibility antigen
 UniProt Gene Name    H2-D1 [Similar Products]
 UniProt Synonym Gene Names    H-2L(q) [Similar Products]
 UniProt Entry Name    O19453_MOUSE
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 UniProt Comments for H2-D1    KLC2: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Belongs to the kinesin light chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor

Cellular Component: ciliary rootlet; microtubule; kinesin complex; neuron projection; cytoskeleton; protein complex; membrane; cell; cytoplasm; intracellular; cytosol

Molecular Function: protein binding; kinesin binding; microtubule motor activity

Biological Process: axon cargo transport; microtubule-based movement
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 Research Articles on H2-D1    1. Data show that At early stages, tumors demonstrated reduced MHC class I expression and increased expression of natural killer group 2D ligands (NKG2D-L).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-H2-D1 antibodyOrgans/Tissues associated with anti-H2-D1 antibody
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with H2-D1 and Kidney
 Brain Antibodies  >1 publications with H2-D1 and Brain
 Blood Antibodies  >1 publications with H2-D1 and Blood
 Spleen Antibodies  >1 publications with H2-D1 and Spleen
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