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anti-H2-K1 antibody :: Mouse anti-Mouse MHC Class 1, H-2Kb Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS633611 anti-H2-K1 antibody
Unit / Price
0.1 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MHC Class 1, H-2Kb (H2-K1), Monoclonal Antibody

 Also Known As   

MHC Class 1, H-2Kb (MHC Class I H-2Kb, H-2 Class I Histocompatibility Antigen K-B alpha Chain, H-2K(B), H2-K1, H-2K, H2-K, H-2K(d), MGC7052, MGC184092) (FITC)

 Product Synonym Names    Anti -MHC Class 1, H-2Kb (MHC Class I H-2Kb, H-2 Class I Histocompatibility Antigen K-B alpha Chain, H-2K(B), H2-K1, H-2K, H2-K, H-2K(d), MGC7052, MGC184092) (FITC)
 Product Gene Name   

anti-H2-K1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000083.5 (34132957..34137278, complement). Location: 17 B1; 17 18.44 cM
 3D Structure    ModBase 3D Structure for P01901
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    AF6-88.5
 Host    Mouse
 Species Reactivity    Mouse
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 Specificity    Recognizes the H-2Kb determinant present on all nucleated cells of mice expressing this MHC class I haplotype. Does not cross react with other haplotypes.
 Purity/Purification    Affinity Purified
Purified by affinity chromatography
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
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 Immunogen    C57BL mouse splenocytes
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
 Other Notes    Small volumes of anti-H2-K1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-H2-K1 antibody

   The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region. There are 3 major MHC class I proteins encoded by the H-2 which are H-2K, H-2L and H-2D. The H- 2K gene is part of the murine H-2 complex on chromosome 17 and there are a large number of variant alleles of this gene.
 Product Categories/Family for anti-H2-K1 antibody    Antibodies; Abs to MHC
 Applications Tested/Suitable for anti-H2-K1 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-H2-K1 antibody    Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 1:10-1:20; 10ul labels 10e6 cells in 100ul
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NCBI/Uniprot data below describe general gene information for H2-K1. It may not necessarily be applicable to this product.
 NCBI GI #    5531260
 NCBI GeneID    14972
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 UniProt Primary Accession #    P01901 [Other Products]
 UniProt Related Accession #    O19449; O19468; O35641; P01901; P01902; P03991; P04223; P14428; Q1XIR8; Q31141 [Other Products]
 Molecular Weight    41,302 Da [Similar Products]
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 NCBI Official Full Name    MHC class I antigen H-2K
 NCBI Official Synonym Full Names    histocompatibility 2, K1, K region
 NCBI Official Symbol    H2-K1 [Similar Products]
 NCBI Official Synonym Symbols   
K-f; H-2K; H2-K; H-2K(d); MGC7052; MGC184092
[Similar Products]
 NCBI Protein Information    H-2 class I histocompatibility antigen, K-W28 alpha chain; H-2K(B); H-2K(K); H-2K(Q); MHC class I antigen; MHC class I heavy chain H2-K; MHC H2-K transplantation antigen; class I major histocompatibility antigen H-2Kd; MHC class I H2-K-b-alpha-2 cell surface glycoprotein; H-2 class I histocompatibility antigen, K-B alpha chain; H-2 class I histocompatibility antigen, K-D alpha chain; H-2 class I histocompatibility antigen, K-K alpha chain; H-2 class I histocompatibility antigen, K-Q alpha chain
 UniProt Protein Name    H-2 class I histocompatibility antigen, K-B alpha chain
 Protein Family    H-2 class I histocompatibility antigen
 UniProt Gene Name    H2-K1 [Similar Products]
 UniProt Synonym Gene Names    H2-K [Similar Products]
 UniProt Entry Name    HA1B_MOUSE
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 UniProt Comments for H2-K1    HLAC iso22: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: Golgi apparatus; cell surface; membrane; endoplasmic reticulum; integral to membrane; MHC class I protein complex; Golgi medial cisterna; external side of plasma membrane

Molecular Function: protein binding; peptide antigen binding; beta-2-microglobulin binding; protein heterodimerization activity; T cell receptor binding; peptide binding; TAP binding; receptor binding

Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen via MHC class I; immune system process; positive regulation of T cell mediated cytotoxicity; defense response to bacterium; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; inner ear development; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
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 Research Articles on H2-K1    1. Adult mice exposed to a noninherited maternal antigen accepts permanently H2-Kb-positive heart allografts despite the presence of normal levels of anti-K(b) T cell receptor transgenic T cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-H2-K1 antibodyDiseases associated with anti-H2-K1 antibody
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with H2-K1 and Inflammation
Organs/Tissues associated with anti-H2-K1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with H2-K1 and Lung
 Spleen Antibodies  >1 publications with H2-K1 and Spleen
 Blood Antibodies  >1 publications with H2-K1 and Blood
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