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anti-HLA-DQB1 antibody :: Rat anti-Mouse MHC Class II Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673639 anti-HLA-DQB1 antibody
Unit / Price
0.5 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MHC Class II (HLA-DQB1), Monoclonal Antibody

 Also Known As   

Rat Anti-Mouse MHC Class II-BIOT

 Product Synonym Names    Rat Anti-Mouse MHC Class II - Biotin; Rat Anti-Mouse MHC Class II
 Product Gene Name   

anti-HLA-DQB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (32627657..32634466, complement). Location: 6p21.3
 3D Structure    ModBase 3D Structure for O19707
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 Clonality    Monoclonal
 Isotype    Rat IgG2b
 Clone Number    NIMR-4
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    MHC Class II molecules
The monoclonal antibody NIMR-4 reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells.
 Form/Format    Biotin (BIOT) Conjugate
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 Characterization    To ensure lot-to-lot consistency, each batch of product is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative data are included in this product insert.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL or 0.2 mg in 2.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Spectral Red (SPRD) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C.
Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-HLA-DQB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HLA-DQB1 antibody   

Flow Cytometry

 Application Notes for anti-HLA-DQB1 antibody    Research Application(s): Complement-dependent cytotoxicity assays

Flow Cytometry Suggested Dilution: <=1 ug/10^6 cells
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NCBI/Uniprot data below describe general gene information for HLA-DQB1. It may not necessarily be applicable to this product.
 NCBI GI #    1160938
 NCBI GeneID    3119
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 UniProt Primary Accession #    O19707 [Other Products]
 UniProt Related Accession #    O19506; O19632; O19707; O19709; O19710; O19711; O19712; O19714; O19715; A0AQY9 [Other Products]
 Molecular Weight    26,489 Da [Similar Products]
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 NCBI Official Full Name    MHC class II
 NCBI Official Synonym Full Names    major histocompatibility complex, class II, DQ beta 1
 NCBI Official Symbol    HLA-DQB1 [Similar Products]
 NCBI Official Synonym Symbols   
IDDM1; CELIAC1; HLA-DQB
[Similar Products]
 NCBI Protein Information    HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class2 antigen; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain; MHC class II antigen HLA-DQ-beta-1; MHC class II HLA-DQ beta glycoprotein; major histocompatibility complex class II beta; HLA class II histocompatibility antigen, DQ beta 1 chain-like
 UniProt Protein Name    MHC class II HLA-DQ-beta-1
 Protein Family    MHC class II transactivator
 UniProt Gene Name    HLA-DQB1 [Similar Products]
 UniProt Entry Name    O19707_HUMAN
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 NCBI Summary for HLA-DQB1    HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]
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 UniProt Comments for HLA-DQB1    Sequence similarities: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS014745
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Product References and Citations for anti-HLA-DQB1 antibody

   1. R.M.E. Parkhouse. 1996. Personal communication.
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 Research Articles on HLA-DQB1    1. that DQB1*0604 hz comprised most to all of the positive association with cervical dystonia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HLA-DQB1 antibodyPathways associated with anti-HLA-DQB1 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >71 publications with HLA-DQB1 and CD4
 INS antibody  >25 publications with HLA-DQB1 and INS
 HLA-DQA2 antibody  >5 publications with HLA-DQB1 and HLA-DQA2
 CD74 antibody  >1 publications with HLA-DQB1 and CD74
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Organs/Tissues associated with anti-HLA-DQB1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >591 publications with HLA-DQB1 and Blood
 Pancreas Antibodies  >92 publications with HLA-DQB1 and Pancreas
 Skin Antibodies  >71 publications with HLA-DQB1 and Skin
 Liver Antibodies  >60 publications with HLA-DQB1 and Liver
 Thyroid Antibodies  >47 publications with HLA-DQB1 and Thyroid
 Brain Antibodies  >43 publications with HLA-DQB1 and Brain
 Eye Antibodies  >41 publications with HLA-DQB1 and Eye
 Heart Antibodies  >28 publications with HLA-DQB1 and Heart
 Lung Antibodies  >28 publications with HLA-DQB1 and Lung
 Intestine Antibodies  >24 publications with HLA-DQB1 and Intestine
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