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anti-MHC Class II antibody :: Mouse MHC Class II Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140118 anti-MHC Class II antibody
Unit / Price
0.5 mg  /  $305 +1 FREE 8GB USB
1 mg  /  $455 +1 FREE 8GB USB
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 Product Name   

MHC Class II, Monoclonal Antibody

 Also Known As   

Mouse Anti MHC Class II (I-A) FITC

 Product Synonym Names    MHC Class II, I-A Antibody, FITC; MHC Class II, (I-A) Mouse Antibody, FITC; MHC Class II FITC
 Product Gene Name   

anti-MHC Class II antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    NYRmI-A
 Host    Mouse
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 Specificity    Recognizes most MHC class II haplotypes (b,f,p,q,r,s,u,v), but weak against I-Ak.
 Purity/Purification    Ion exchange column.
 Concentration    1mg/ml in PBS (after reconstitution). (lot specific)
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 Reconstitution    Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
 Immunogen    Purified mouse LN B cells (C3H anti-C57Bl6).
 Antibody Properties    Cytotoxic and staining antibody. For staining, use 10ml/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator.
 Available Conjugates    This antibody is also available unconjugated and conjugated to Biotin.
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 Preparation and Storage    Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-MHC Class II antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MHC Class II antibody

   Introduction: MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
 Product Categories/Family for anti-MHC Class II antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
NCBI/Uniprot data below describe general gene information for MHC Class II. It may not necessarily be applicable to this product.
 NCBI GI #    74739520
 NCBI Accession #    O19707 [Other Products]
 Molecular Weight    26,489 Da
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 NCBI Official Full Name    MHC class II HLA-DQ-beta-1
 UniProt Protein Name    MHC class II HLA-DQ-beta-1
 UniProt Synonym Protein Names   
MHC class II HLA-DQ-beta-1
 Protein Family    MHC class II transactivator
 UniProt Gene Name    HLA-DQB1 [Similar Products]
 UniProt Entry Name    O19707_HUMAN
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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