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anti-MICB antibody :: Mouse anti-Human MICB Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS335251 anti-MICB antibody
Unit / Price
0.2 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MICB, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti-Human MICB Monoclonal Antibody, Azide Free Clone B-D55

 Product Synonym Names    MICB
 Product Gene Name   

anti-MICB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    180300
 3D Structure    ModBase 3D Structure for Q29980
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    B-D55
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognises both natural and recombinant human MICB
 Purity/Purification    Ion exchange chromatography
 Form/Format    Azide free
Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free
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 Antigen    MICB
 Hybridoma    Myeloma X63/AG.8653 x Balb/c node cells
 Immunisation    Recombinant human MICB
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 Preparation and Storage    Stable at +2-8 degree C for 12 months. For longer storage, freeze aliquots.
 Other Notes    Small volumes of anti-MICB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MICB antibody   

ELISA (EIA)

 Application Notes for anti-MICB antibody    Recognises soluble antigen
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NCBI/Uniprot data below describe general gene information for MICB. It may not necessarily be applicable to this product.
 NCBI GI #    4521252
 NCBI GeneID    4277
 NCBI Accession #    BAA23485.1 [Other Products]
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 UniProt Primary Accession #    Q29980 [Other Products]
 UniProt Secondary Accession #    O14499; O14500; O19798; O19799; O19800; O19801; O19802; A2AC57; A6NP85; B0UZ10; B2RAK2 [Other Products]
 UniProt Related Accession #    Q29980 [Other Products]
 Molecular Weight    4,287 Da
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 NCBI Official Full Name    MICB, partial
 NCBI Official Synonym Full Names    MHC class I polypeptide-related sequence B
 NCBI Official Symbol    MICB [Similar Products]
 NCBI Official Synonym Symbols   
PERB11.2
[Similar Products]
 NCBI Protein Information    MHC class I polypeptide-related sequence B
 UniProt Protein Name    MHC class I polypeptide-related sequence B
 Protein Family    MHC class I polypeptide-related sequence
 UniProt Gene Name    MICB [Similar Products]
 UniProt Synonym Gene Names    MIC-B [Similar Products]
 UniProt Entry Name    MICB_HUMAN
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 NCBI Summary for MICB    This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for MICB    MICB: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. The MICB*004 allele is associated with rheumatoid arthritis. Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk. Belongs to the MHC class I family. MIC subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; regulation of immune response; response to retinoic acid; viral reproduction; natural killer cell mediated cytotoxicity; response to heat; cytolysis; immune response-activating cell surface receptor signaling pathway; response to oxidative stress; negative regulation of defense response to virus by host; gamma-delta T cell activation; T cell mediated cytotoxicity
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 Research Articles on MICB    1. Data indicate that MHC class I chain-related protein A (MICA)( *)010, MICA( *)A5 and MHC class I chain-related protein B (MICB)( *)005:02 were the most frequent alleles.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MICB antibodyDiseases associated with anti-MICB antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >52 publications with MICB and Carcinoma
 Adenocarcinoma Antibodies  >27 publications with MICB and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >21 publications with MICB and Cardiovascular Diseases
 Necrosis Antibodies  >20 publications with MICB and Necrosis
 Liver Neoplasms Antibodies  >13 publications with MICB and Liver Neoplasms
 Lung Diseases Antibodies  >12 publications with MICB and Lung Diseases
 Neoplasm Metastasis Antibodies  >12 publications with MICB and Neoplasm Metastasis
 Inflammation Antibodies  >11 publications with MICB and Inflammation
 Carcinoma, Hepatocellular Antibodies  >11 publications with MICB and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >10 publications with MICB and Breast Neoplasms
Organs/Tissues associated with anti-MICB antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >220 publications with MICB and Blood
 Lung Antibodies  >21 publications with MICB and Lung
 Liver Antibodies  >19 publications with MICB and Liver
 Intestine Antibodies  >11 publications with MICB and Intestine
 Kidney Antibodies  >11 publications with MICB and Kidney
 Lymph Antibodies  >7 publications with MICB and Lymph
 Bone Marrow Antibodies  >7 publications with MICB and Bone Marrow
 Brain Antibodies  >6 publications with MICB and Brain
 Thymus Antibodies  >5 publications with MICB and Thymus
 Vascular Antibodies  >4 publications with MICB and Vascular
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