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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MICU1 antibody :: Mouse MICU1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9400198
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MICU1, Monoclonal Antibody

★Popular Item★
 Also Known As   

MICU1 Monoclonal Antibody

 Product Gene Name   

anti-MICU1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605084
 3D Structure    ModBase 3D Structure for Q9BPX6
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous MICU1 protein.
 Purity/Purification    The antibody was affinity-purified from antiserum by affinity-chromatography
 Form/Format    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Recombinant Protein
 Target Name    MICU1
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-MICU1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-MICU1 antibody    Total protein Ab
 Applications Tested/Suitable for anti-MICU1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MICU1 antibody    Western blotting: 1:1000-2000
Immunohistochemistry: 1:100-200
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 Western Blot (WB) of anti-MICU1 antibody    Western blot analysis of 1) MCF7, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using MICU1 Monoclonal Antibody.
anti-MICU1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MICU1 antibody    Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using MICU1 Monoclonal Antibody.
anti-MICU1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MICU1. It may not necessarily be applicable to this product.
 NCBI GI #    306922382
 NCBI GeneID    10367
 NCBI Accession #    NP_001182447.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001195518.1 [Other Products]
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 UniProt Primary Accession #    Q9BPX6 [Other Products]
 UniProt Secondary Accession #    O75785; Q9H9N6; Q9UFX0; A8MV96; B3KN20; B4DJH9; B4DPI1; B5MBY3; D3YTJ3 [Other Products]
 UniProt Related Accession #    Q9BPX6 [Other Products]
 Molecular Weight    55kd
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 NCBI Official Full Name    calcium uptake protein 1, mitochondrial isoform 2
 NCBI Official Synonym Full Names    mitochondrial calcium uptake 1
 NCBI Official Symbol    MICU1 [Similar Products]
 NCBI Official Synonym Symbols   
CALC; EFHA3; MPXPS; CBARA1
[Similar Products]
 NCBI Protein Information    calcium uptake protein 1, mitochondrial
 UniProt Protein Name    Calcium uptake protein 1, mitochondrial
 UniProt Synonym Protein Names   
Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Allergen: Hom s 4
 Protein Family    Calcium uptake protein
 UniProt Gene Name    MICU1 [Similar Products]
 UniProt Synonym Gene Names    CALC; CBARA1; ara CALC [Similar Products]
 UniProt Entry Name    MICU1_HUMAN
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 NCBI Summary for MICU1    This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
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 UniProt Comments for MICU1    MICU1: Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Membrane protein, integral; Calcium-binding

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; intracellular

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; calcium ion binding

Biological Process: mitochondrial calcium ion homeostasis; defense response; mitochondrial calcium ion transport; protein homooligomerization; elevation of mitochondrial calcium ion concentration

Disease: Myopathy With Extrapyramidal Signs
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 Research Articles on MICU1    1. Expression of MICU1 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MICU1 antibodyDiseases associated with anti-MICU1 antibody
 Reference Product  PubMed Publications
 MCU antibody  >37 publications with MICU1 and MCU
 LETM1 antibody  >8 publications with MICU1 and LETM1
 CCDC90A antibody  >1 publications with MICU1 and CCDC90A
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with MICU1 and Inflammation
 Movement Disorders Antibodies  >3 publications with MICU1 and Movement Disorders
 Immune System Diseases Antibodies  >2 publications with MICU1 and Immune System Diseases
 Heart Diseases Antibodies  >2 publications with MICU1 and Heart Diseases
 Muscular Diseases Antibodies  >2 publications with MICU1 and Muscular Diseases
 Learning Disorders Antibodies  >2 publications with MICU1 and Learning Disorders
 Ovarian Diseases Antibodies  >1 publications with MICU1 and Ovarian Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with MICU1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with MICU1 and Liver Neoplasms
 Necrosis Antibodies  >1 publications with MICU1 and Necrosis
Organs/Tissues associated with anti-MICU1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with MICU1 and Liver
 Blood Antibodies  >3 publications with MICU1 and Blood
 Heart Antibodies  >3 publications with MICU1 and Heart
 Muscle Antibodies  >2 publications with MICU1 and Muscle
 Pancreas Antibodies  >2 publications with MICU1 and Pancreas
 Skin Antibodies  >2 publications with MICU1 and Skin
 Brain Antibodies  >2 publications with MICU1 and Brain
 Bone Antibodies  >1 publications with MICU1 and Bone
 Embryonic Tissue Antibodies  >1 publications with MICU1 and Embryonic Tissue
 Vascular Antibodies  >1 publications with MICU1 and Vascular
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