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anti-MIP-3beta antibody :: Mouse anti-Human MIP-3beta Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS695017 anti-MIP-3beta antibody
Unit / Price
0.5 mg  /  $185 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MIP-3beta, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-human MIP-3beta

 Product Synonym Names    Anti-Human MIP-3beta
 Product Gene Name   

anti-MIP-3beta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602227
 3D Structure    ModBase 3D Structure for Q99731
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 Clonality    Monoclonal
 Isotype    Mouse IgG1 kappa
 Clone Number    G5_ 4E11.3
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    A sterile filtered antibody solution was lyophilized from PBS.
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 Preparation    Produced in BALB/c mice using highly pure recombinant Human MIP-3f3 as the immunizing antigen. This antibody was purified from cell culture by Protein A affinity chromatography
 Immunogen    E.coli derived recombinant Human MIP-3f3.
 Reconstitution    Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 1.0 mg/mL
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of anti-MIP-3beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MIP-3beta antibody

   Produced in BALB/c mice using highly pure recombinant Human MIP-3beta as the immunizing antigen. This IgG1K antibody was purified from cell culture by Protein A affinity chromatography.
 Applications Tested/Suitable for anti-MIP-3beta antibody   

Immunohistochemistery (IHC), ELISA (EIA), Western Blot (WB)

 Application Notes for anti-MIP-3beta antibody    Immunostaining: This antibody stained PBMC. The primary antibody was incubated at 5.0 ug/ml for one hour at room temperature followed by a fluorescent labeled secondary antibody.

Sandwich ELISA: In a sandwich ELISA (assuming 100 ul/well), a concentration of 2.0-4.0 ug/ml of this antibody will detect recombinant Human MIP-3beta when used with biotinylated antigen affinity purified anti-Human MIP-3beta as the detection antibody at a concentration of approximately 0.5-1.0 ug/ml.

Western Blot: To detect Human MIP-3f3 by Western Blot analYSis this antibody can be used at a concentration of 1.0-2.0 ug/ml. When used in conjunction with compatible secondry reagents the detection limit for recombinant Human MIP-3beta is 2.0-4.0 ng/lane, under reducing conditions.

Optimal dilutions should be determined by each laboratory for each application.
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NCBI/Uniprot data below describe general gene information for MIP-3beta. It may not necessarily be applicable to this product.
 NCBI GI #    2842763
 NCBI GeneID    6363
 NCBI Accession #    Q99731.1 [Other Products]
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 UniProt Primary Accession #    Q99731 [Other Products]
 UniProt Secondary Accession #    O00697; O00736 [Other Products]
 UniProt Related Accession #    Q99731 [Other Products]
 Molecular Weight    10,993 Da
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 NCBI Official Full Name    C-C motif chemokine 19
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 19
 NCBI Official Symbol    CCL19 [Similar Products]
 NCBI Official Synonym Symbols   
ELC; CKb11; MIP3B; MIP-3b; SCYA19
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 19; exodus-3; CK beta-11; MIP-3-beta; EBI1 ligand chemokine; EBI1-ligand chemokine; CC chemokine ligand 19; beta chemokine exodus-3; beta-chemokine exodus-3; small-inducible cytokine A19; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; epstein-Barr virus-induced molecule 1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19
 UniProt Protein Name    C-C motif chemokine 19
 UniProt Synonym Protein Names   
Beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; Macrophage inflammatory protein 3 beta; MIP-3-beta; Small-inducible cytokine A19
 UniProt Gene Name    CCL19 [Similar Products]
 UniProt Synonym Gene Names    ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta [Similar Products]
 UniProt Entry Name    CCL19_HUMAN
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 NCBI Summary for MIP-3beta    This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]
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 UniProt Comments for MIP-3beta    CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR chemokine receptor binding; chemokine activity; chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding

Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; activation of JNK activity; positive regulation of receptor-mediated endocytosis; dendritic cell chemotaxis; cell communication; establishment of T cell polarity; positive regulation of T cell proliferation; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation
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 Research Articles on MIP-3beta    1. Serum CCL19 and CCL21 were up-regulated during Rickettsia conorii infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MIP-3beta antibodyPathways associated with anti-MIP-3beta antibody
 Reference Product  PubMed Publications
 CCR7 antibody  >437 publications with MIP-3beta and CCR7
 CXCL13 antibody  >97 publications with MIP-3beta and CXCL13
 CXCL10 antibody  >55 publications with MIP-3beta and CXCL10
 CCR5 antibody  >50 publications with MIP-3beta and CCR5
 CCR6 antibody  >47 publications with MIP-3beta and CCR6
 CXCL9 antibody  >36 publications with MIP-3beta and CXCL9
 CXCR5 antibody  >31 publications with MIP-3beta and CXCR5
 CCL25 antibody  >29 publications with MIP-3beta and CCL25
 CCR1 antibody  >23 publications with MIP-3beta and CCR1
 CXCL11 antibody  >21 publications with MIP-3beta and CXCL11
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
Diseases associated with anti-MIP-3beta antibodyOrgans/Tissues associated with anti-MIP-3beta antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >149 publications with MIP-3beta and Inflammation
 Necrosis Antibodies  >66 publications with MIP-3beta and Necrosis
 Respiratory Tract Diseases Antibodies  >47 publications with MIP-3beta and Respiratory Tract Diseases
 Lung Diseases Antibodies  >43 publications with MIP-3beta and Lung Diseases
 Vascular Diseases Antibodies  >29 publications with MIP-3beta and Vascular Diseases
 Hypersensitivity Antibodies  >27 publications with MIP-3beta and Hypersensitivity
 Death Antibodies  >21 publications with MIP-3beta and Death
 Lung Neoplasms Antibodies  >14 publications with MIP-3beta and Lung Neoplasms
 Liver Diseases Antibodies  >13 publications with MIP-3beta and Liver Diseases
 Respiratory Tract Infections Antibodies  >13 publications with MIP-3beta and Respiratory Tract Infections
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >279 publications with MIP-3beta and Lymph Node
 Vascular Antibodies  >82 publications with MIP-3beta and Vascular
 Spleen Antibodies  >70 publications with MIP-3beta and Spleen
 Lung Antibodies  >64 publications with MIP-3beta and Lung
 Thymus Antibodies  >37 publications with MIP-3beta and Thymus
 Brain Antibodies  >30 publications with MIP-3beta and Brain
 Intestine Antibodies  >23 publications with MIP-3beta and Intestine
 Eye Antibodies  >19 publications with MIP-3beta and Eye
 Pancreas Antibodies  >17 publications with MIP-3beta and Pancreas
 Heart Antibodies  >14 publications with MIP-3beta and Heart
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