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anti-MLL antibody :: Mouse anti-Human MLL Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533354
Western Blot (WB)
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MLL, Monoclonal Antibody

 Also Known As   

MLL antibody

 Product Synonym Names    Monoclonal MLL; Anti-MLL; Zinc finger protein HRX; ALL 1; MLL; ALL-1; Lysine N-methyltransferase 2A; HRX; Anti MLL; Myeloid/lymphoid leukemia; Trithorax-like protein
 Product Gene Name   

anti-MLL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    159555
 3D Structure    ModBase 3D Structure for Q03164
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10F8D7
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    MLL contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes.
 Immunogen    MLL antibody was raised in Mouse using a purified recombinant fragment of MLL(aa3751-3968) expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-MLL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MLL antibody

   Mouse monoclonal MLL antibody
 Product Categories/Family for anti-MLL antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-MLL antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-MLL antibody    ELISA: 1:10,000
IHC: 1:200-1:1000
WB: 1:500-1:2000
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 Western Blot (WB) of anti-MLL antibody    Western Blot showing MLL antibody used against truncated MLL recombinant protein (1) and truncated GFP-MLL (aa3714-3969) transfected Cos7 cell lysate (2).
anti-MLL antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MLL. It may not necessarily be applicable to this product.
 NCBI GI #    1042099
 NCBI GeneID    4297
 NCBI Accession #    AAB34771.1 [Other Products]
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 UniProt Primary Accession #    Q03164 [Other Products]
 UniProt Secondary Accession #    Q13743; Q13744; Q14845; Q16364; Q59FF2; Q6UBD1; Q9HBJ3; Q9UD94; Q9UMA3; E9PQG7 [Other Products]
 UniProt Related Accession #    Q03164 [Other Products]
 Molecular Weight    432,052 Da
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 NCBI Official Full Name    MLL, partial
 NCBI Official Synonym Full Names    lysine (K)-specific methyltransferase 2A
 NCBI Official Symbol    KMT2A [Similar Products]
 NCBI Official Synonym Symbols   
HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; MLL-AF9; MLL/GAS7; TET1-MLL
[Similar Products]
 NCBI Protein Information    histone-lysine N-methyltransferase 2A
 UniProt Protein Name    Histone-lysine N-methyltransferase 2A
 UniProt Synonym Protein Names   
ALL-1; CXXC-type zinc finger protein 7; Myeloid/lymphoid or mixed-lineage leukemia; Myeloid/lymphoid or mixed-lineage leukemia protein 1; Trithorax-like protein; Zinc finger protein HRX
 UniProt Gene Name    KMT2A [Similar Products]
 UniProt Synonym Gene Names    ALL1; CXXC7; HRX; HTRX; MLL; MLL1; TRX1; Lysine N-methyltransferase 2A; p320; p180 [Similar Products]
 UniProt Entry Name    KMT2A_HUMAN
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 NCBI Summary for MLL    This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
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 UniProt Comments for MLL    MLL: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins MLL-MLLT1, MLL-MLLT3 and MLL-ELL interact with PPP1R15A and, on the contrary to unfused MLL, inhibit PPP1R15A-induced apoptosis. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein lysine; Oncoprotein; EC 2.1.1.43; Methyltransferase; Cell cycle regulation; Transcription factor

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: nucleoplasm; histone methyltransferase complex; cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; AT DNA binding; unmethylated CpG binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; anterior/posterior pattern formation; negative regulation of cell proliferation; establishment and/or maintenance of chromatin architecture; apoptosis; embryonic hemopoiesis; positive regulation of transcription, DNA-dependent; positive regulation of transporter activity; histone H3-K4 methylation; DNA methylation; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; circadian regulation of gene expression

Disease: Hairy Elbows, Short Stature, Facial Dysmorphism, And Developmental Delay
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 Research Articles on MLL    1. inhibition of DOT1L, in combination with DNA damaging chemotherapy, represents a promising approach to improving outcomes for MLL-rearranged leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MLL antibodyDiseases associated with anti-MLL antibody
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >22 publications with MLL and Leukemia
 Leukemia, Myeloid Antibodies  >12 publications with MLL and Leukemia, Myeloid
 Leukemia, Lymphoid Antibodies  >12 publications with MLL and Leukemia, Lymphoid
 Leukemia, Myeloid, Acute Antibodies  >5 publications with MLL and Leukemia, Myeloid, Acute
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >3 publications with MLL and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Chromosome Aberrations Antibodies  >2 publications with MLL and Chromosome Aberrations
 Adenocarcinoma Antibodies  >2 publications with MLL and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >1 publications with MLL and Neoplasms, Experimental
 Prostatic Diseases Antibodies  >1 publications with MLL and Prostatic Diseases
 Leukemia, Monocytic, Acute Antibodies  >1 publications with MLL and Leukemia, Monocytic, Acute
Organs/Tissues associated with anti-MLL antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with MLL and Brain
 Blood Antibodies  >3 publications with MLL and Blood
 Bone Antibodies  >2 publications with MLL and Bone
 Bone Marrow Antibodies  >1 publications with MLL and Bone Marrow
 Nerve Antibodies  >1 publications with MLL and Nerve
 Thyroid Antibodies  >1 publications with MLL and Thyroid
 Muscle Antibodies  >1 publications with MLL and Muscle
 Prostate Antibodies  >1 publications with MLL and Prostate
 Lung Antibodies  >1 publications with MLL and Lung
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