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anti-MME antibody :: Mouse anti-Human MME / CD10 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245033
Immunohistochemistry (IHC)
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MME / CD10, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal (IgG2b) to Human MME / CD10

 Product Synonym Names    Anti-MME / CD10 Antibody IHC-plus; MME; Atriopeptidase; CALLA; CD10; EPN; Membrane metallo-endopeptidase; NEP; Neprilysin; Neutral endopeptidase; Neutral endopeptidase 24.11; CD10 antigen; Enkephalinase; Neprylisin; SFE; Skin fibroblast elastase; Human MME; CD10
 Product Gene Name   

anti-MME antibody

[Similar Products]
 Product Synonym Gene Name    CD10 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120520
 3D Structure    ModBase 3D Structure for P08473
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 Clonality    Monoclonal
 Isotype    IgG2b
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Ni-NTA purified recombinant human CD-10 expressed in E Coli strain BL21 (DE3)
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.03% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant human MME / CD10.
 Immunogen Type    Recombinant protein
 Immunogen    MME / CD10 antibody was raised against recombinant human MME / CD10.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-MME antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MME antibody

   MME, also known as Neprilysin or CALLA for common acute lymphocytic leukemia antigen, is a Metallopeptidase M13 type protease. MME functions as a peptidase and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. The protein is found on leukemic cells of pre-B phenotype and serves as a cell-surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).
 Product Categories/Family for anti-MME antibody    Family: Protease
Subfamily: Metallopeptidase M13
 Applications Tested/Suitable for anti-MME antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), ELISA (EIA)

 Application Notes for anti-MME antibody    ELISA (1:10000), IHC-Fr (1:200 - 1:400), IHC-P (1:100 - 1:200)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MME antibody    Anti-CD10 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
anti-MME antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MME. It may not necessarily be applicable to this product.
 NCBI GI #    116256329
 NCBI GeneID    4311
 NCBI Accession #    NP_000893.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000902.3 [Other Products]
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 UniProt Primary Accession #    P08473 [Other Products]
 UniProt Secondary Accession #    Q3MIX4; A8K6U6; D3DNJ9 [Other Products]
 UniProt Related Accession #    P08473 [Other Products]
 Molecular Weight    85,514 Da
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 NCBI Official Full Name    neprilysin
 NCBI Official Synonym Full Names    membrane metallo-endopeptidase
 NCBI Official Symbol    MME [Similar Products]
 NCBI Official Synonym Symbols   
NEP; SFE; CD10; CALLA
[Similar Products]
 NCBI Protein Information    neprilysin; enkephalinase; atriopeptidase; neprilysin-390; neprilysin-411; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
 UniProt Protein Name    Neprilysin
 UniProt Synonym Protein Names   
Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10
 Protein Family    Neprilysin
 UniProt Gene Name    MME [Similar Products]
 UniProt Synonym Gene Names    EPN; CALLA; NEP; Neutral endopeptidase; SFE [Similar Products]
 UniProt Entry Name    NEP_HUMAN
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 NCBI Summary for MME    This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MME    CD10: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family.

Protein type: EC 3.4.24.11; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q25.2

Cellular Component: synaptic vesicle; focal adhesion; axon; integral to plasma membrane; cytoplasm; dendrite; plasma membrane; integral to membrane; synapse; brush border

Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity; exopeptidase activity; peptide binding

Biological Process: peptide metabolic process; cellular protein metabolic process; beta-amyloid metabolic process; creatinine metabolic process; angiotensin maturation; kidney development; proteolysis; sensory perception of pain

Disease: Membranous Nephropathy, Susceptibility To
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 Research Articles on MME    1. MME expression level was differentially altered in Crohn disease and ulcerative colitis patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MME antibodyPathways associated with anti-MME antibody
 Reference Product  PubMed Publications
 TAC1 antibody  >2 publications with MME and TAC1
 EDN1 antibody  >1 publications with MME and EDN1
 ICAM1 antibody  >1 publications with MME and ICAM1
 TGFB1 antibody  >1 publications with MME and TGFB1
 AKT1 antibody  >1 publications with MME and AKT1
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 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with anti-MME antibodyOrgans/Tissues associated with anti-MME antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >23 publications with MME and Nervous System Diseases
 Carcinoma Antibodies  >17 publications with MME and Carcinoma
 Heart Diseases Antibodies  >16 publications with MME and Heart Diseases
 Kidney Diseases Antibodies  >14 publications with MME and Kidney Diseases
 Necrosis Antibodies  >13 publications with MME and Necrosis
 Inflammation Antibodies  >11 publications with MME and Inflammation
 Lung Diseases Antibodies  >11 publications with MME and Lung Diseases
 Neoplasms, Experimental Antibodies  >11 publications with MME and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >10 publications with MME and Disease Models, Animal
 Edema Antibodies  >7 publications with MME and Edema
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >55 publications with MME and Blood
 Brain Antibodies  >24 publications with MME and Brain
 Heart Antibodies  >21 publications with MME and Heart
 Liver Antibodies  >21 publications with MME and Liver
 Lung Antibodies  >19 publications with MME and Lung
 Muscle Antibodies  >16 publications with MME and Muscle
 Kidney Antibodies  >16 publications with MME and Kidney
 Bone Antibodies  >13 publications with MME and Bone
 Skin Antibodies  >9 publications with MME and Skin
 Eye Antibodies  >9 publications with MME and Eye
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