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anti-MPO antibody :: anti-Human MPO / Myeloperoxidase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245894
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MPO / Myeloperoxidase, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal [clone 9B12G7] (IgG1) to Human MPO / Myeloperoxidase

 Product Synonym Names    Anti-MPO / Myeloperoxidase Antibody (clone 9B12G7) IHC-plus; MPO; Myeloperoxidase precursor; Myeloperoxidase; Human MPO; Myeloperoxidase
 Product Gene Name   

anti-MPO antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 606989
 3D Structure    ModBase 3D Structure for P05164
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9B12G7
 Host    MPO/Myeloperoxidase antibody was produced in Mouse.
 Species Reactivity    Human
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 Specificity    Human MPO
 Purity/Purification    Ascites
 Form/Format    Ascites fluid, 0.03% sodium azide
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 Target    Human MPO / Myeloperoxidase
 Target Species    Human
 Immunogen Description    Purified recombinant fragment of MPO(aa1-193) expressed in E Coli.
 Immunogen Species    MPO/Myeloperoxidase antibody was raised against Human
 Immunogen Species    MPO/Myeloperoxidase antibody was raised against purified recombinant fragment of MPO(aa1-193) expressed in E Coli.
 Usage    Immunohistochemistry: MBS245894 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working dilution for MBS245894 was determined to be 1:200.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-MPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MPO antibody

   Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains (12 kD) and 2 heavy chains (60 kD). This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. It is released in a degranulation process in response to bursts of oxygen consumption, which also forms H2O2. MPO and H2O2 form a complex that oxidases a large variety of substances some of which have microbicidal effects. The gene for MPO is translocated in patients with acute promyelocytic leukemia and is mutated in hereditary MPO deficiency.
 Applications Tested/Suitable for anti-MPO antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MPO antibody    ELISA (1:10000), IHC-P (1:200 - 1:400), WB (1:500 - 1:2000)

Usage: Immunohistochemistry: MBS245894 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working dilution for MBS245894 was determined to be 1:200.
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 Immunohistochemistry (IHC) of anti-MPO antibody    Anti-MPO / Myeloperoxidase antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
anti-MPO antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-MPO antibody    Anti-MPO / Myeloperoxidase antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
anti-MPO antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-MPO antibody    Western blot of anti-MPO monoclonal antibody against truncated Trx-MPO recombinant protein(1), truncated MBP-MPO(aa1-193) recombinant protein(2) and truncated MPO(aa165-745)-hIgGFc transfected CHO-K1 cell lysate(3).
anti-MPO antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MPO. It may not necessarily be applicable to this product.
 NCBI GI #    4557759
 NCBI GeneID    4353
 NCBI Accession #    NP_000241.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000250.1 [Other Products]
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 UniProt Primary Accession #    P05164 [Other Products]
 UniProt Secondary Accession #    Q14862; Q4PJH5; Q9UCL7; A1L4B8 [Other Products]
 UniProt Related Accession #    P05164 [Other Products]
 Molecular Weight    87,248 Da
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 NCBI Official Full Name    myeloperoxidase
 NCBI Official Synonym Full Names    myeloperoxidase
 NCBI Official Symbol    MPO [Similar Products]
 NCBI Protein Information    myeloperoxidase
 UniProt Protein Name    Myeloperoxidase
 Protein Family    Myeloperoxidase
 UniProt Gene Name    MPO [Similar Products]
 UniProt Synonym Gene Names    MPO [Similar Products]
 UniProt Entry Name    PERM_HUMAN
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 NCBI Summary for MPO    Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
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 UniProt Comments for MPO    MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.11.2.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule

Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding

Biological Process: response to food; respiratory burst during defense response; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; response to lipopolysaccharide; defense response; response to yeast; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging

Disease: Myeloperoxidase Deficiency; Alzheimer Disease
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 Research Articles on MPO    1. MPO activity increases when it is adsorbed at the surface of low density lipoproteins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MPO antibodyPathways associated with anti-MPO antibody
 Reference Product  PubMed Publications
 MYB antibody  >11 publications with MPO and MYB
 PRTN3 antibody  >6 publications with MPO and PRTN3
 JAK2 antibody  >5 publications with MPO and JAK2
 ALB antibody  >4 publications with MPO and ALB
 ELANE antibody  >4 publications with MPO and ELANE
 IL23A antibody  >1 publications with MPO and IL23A
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Vitamin B12 Metabolism Pathway antibodies  Vitamin B12 Metabolism Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with anti-MPO antibodyOrgans/Tissues associated with anti-MPO antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2573 publications with MPO and Inflammation
 Cardiovascular Diseases Antibodies  >2029 publications with MPO and Cardiovascular Diseases
 Necrosis Antibodies  >1465 publications with MPO and Necrosis
 Lung Diseases Antibodies  >1173 publications with MPO and Lung Diseases
 Reperfusion Injury Antibodies  >838 publications with MPO and Reperfusion Injury
 Colitis Antibodies  >663 publications with MPO and Colitis
 Kidney Diseases Antibodies  >632 publications with MPO and Kidney Diseases
 Edema Antibodies  >601 publications with MPO and Edema
 Heart Diseases Antibodies  >434 publications with MPO and Heart Diseases
 Hemorrhage Antibodies  >422 publications with MPO and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4920 publications with MPO and Blood
 Lung Antibodies  >1467 publications with MPO and Lung
 Kidney Antibodies  >718 publications with MPO and Kidney
 Brain Antibodies  >585 publications with MPO and Brain
 Bone Antibodies  >386 publications with MPO and Bone
 Bone Marrow Antibodies  >306 publications with MPO and Bone Marrow
 Eye Antibodies  >94 publications with MPO and Eye
 Lymph Node Antibodies  >89 publications with MPO and Lymph Node
 Thyroid Antibodies  >78 publications with MPO and Thyroid
 Embryonic Tissue Antibodies  >41 publications with MPO and Embryonic Tissue
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