Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow MPO rightarrow Monoclonal MPO  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Pancreatic Amylase (PAMY) ELISA Kit
 • MC3 Receptor Antibody
 • Teratocarcinoma Derived Growth Factor 1 (TDGF1) ELISA Kit
 • Matrilin 3 (MATN3) ELISA Kit
 • alpha Synuclein (alpha-SYN) ELISA Kit
 • CA 242 ELISA Kit
 • Insulin Antibody
 • Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit
 • PTGS2 - COX2 - COX-2 Antibody
 • PIAS2 Antibody
 • ERBB2IP Antibody
 • Dopamine receptor D1-DRD1 Antibody
 • histamine receptor H2 (HRH2) ELISA Kit
 • Activation-induced Cytidine Deaminase (AICDA) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MPO antibody :: Mouse MPO Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS584204 anti-MPO antibody
Unit / Price
0.05 mg  /  $475 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MPO, Monoclonal Antibody

★Popular Item★
 Also Known As   

MPO, Rat, mAb 2D4, Biotin

 Product Gene Name   

anti-MPO antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    606989
Section Bar
 Clonality    Monoclonal
 Isotype    Mouse IgG1
 Host    Mouse
 Species Reactivity    Reactivity: Rat. Cross reactivity: Mouse
Section Bar
 Form/Format    0.5 ml (100 ug/ml) 0.2 um filtered biotinylated antibody solution in PBS, containing 0.02% sodium azid and 0.1%bovine serum albumin.
Section Bar
 Conjugate    Biotin
Section Bar
 Preparation and Storage    Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for one year.
 Other Notes    Small volumes of anti-MPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-MPO antibody

   Product Description: The monoclonal antibody 2D4 reacts with rat myeloperoxidase (MPO). MPO is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has more attracted clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections. The monoclonal antibody 2D4 cross reacts with mouse MPO.
 Applications Tested/Suitable for anti-MPO antibody   

Flow Cytometry (FC/FACS), Immunoassay (IA), Immunofluorescence (IF), Immunohistology-Paraffin (IHC-P)

 Application Notes for anti-MPO antibody    Application Use: For flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for MPO. It may not necessarily be applicable to this product.
 NCBI GI #    4557759
 NCBI GeneID    4353
 NCBI Accession #    NP_000241.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000250.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q14862; Q4PJH5; Q9UCL7; A1L4B8 [Other Products]
 UniProt Related Accession #    P05164 [Other Products]
 Molecular Weight    87,248 Da
Table BarTOPTable Bar
 NCBI Official Full Name    myeloperoxidase
 NCBI Official Synonym Full Names    myeloperoxidase
 NCBI Official Symbol    MPO [Similar Products]
 NCBI Protein Information    myeloperoxidase
 UniProt Protein Name    Myeloperoxidase
 Protein Family    Myeloperoxidase
 UniProt Gene Name    MPO [Similar Products]
 UniProt Synonym Gene Names    MPO [Similar Products]
 UniProt Entry Name    PERM_HUMAN
Section Bar
 NCBI Summary for MPO    Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for MPO    MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.11.2.2

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule

Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding

Biological Process: response to food; respiratory burst during defense response; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; defense response; response to lipopolysaccharide; response to yeast; response to oxidative stress; defense response to fungus; aging; negative regulation of apoptosis

Disease: Myeloperoxidase Deficiency; Alzheimer Disease
Table BarTOPTable Bar
 Research Articles on MPO    1. Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-MPO antibodyPathways associated with anti-MPO antibody
 Reference Product  PubMed Publications
 PRTN3 antibody  >200 publications with MPO and PRTN3
 MYB antibody  >11 publications with MPO and MYB
 JAK2 antibody  >5 publications with MPO and JAK2
 ALB antibody  >4 publications with MPO and ALB
 ELANE antibody  >2 publications with MPO and ELANE
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Vitamin B12 Metabolism Pathway antibodies  Vitamin B12 Metabolism Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with anti-MPO antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2477 publications with MPO and Inflammation
 Cardiovascular Diseases Antibodies  >1978 publications with MPO and Cardiovascular Diseases
 Necrosis Antibodies  >1410 publications with MPO and Necrosis
 Lung Diseases Antibodies  >1145 publications with MPO and Lung Diseases
 Reperfusion Injury Antibodies  >815 publications with MPO and Reperfusion Injury
 Colitis Antibodies  >646 publications with MPO and Colitis
 Kidney Diseases Antibodies  >620 publications with MPO and Kidney Diseases
 Edema Antibodies  >584 publications with MPO and Edema
 Heart Diseases Antibodies  >425 publications with MPO and Heart Diseases
 Hemorrhage Antibodies  >417 publications with MPO and Hemorrhage
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions