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anti-ABCC3 antibody :: Mouse anti-Human MRP3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS632159
Test Data
Unit / Price
1 mL  /  $700 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MRP3 (ABCC3), Monoclonal Antibody

★Popular Item★
 Also Known As   

MRP3 (Multidrug Resistance-associated Protein 3, ABC31, ATP Binding Cassette Sub-family C Member 3, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 3, ABCC3, Canalicular Multispecific Organic Anion Transporter 2, CMOAT2, DKFZp686E22157, EST90757, MLP2

 Product Synonym Names    Anti -MRP3 (Multidrug Resistance-associated Protein 3, ABC31, ATP Binding Cassette Sub-family C Member 3, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 3, ABCC3, Canalicular Multispecific Organic Anion Transporter 2, CMOAT2, DKFZp686E22157, EST90757, MLP2
 Product Gene Name   

anti-ABCC3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (48712218..48769063). Location: 17q22
 OMIM    604323
 3D Structure    ModBase 3D Structure for O15438
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    M3II-9
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes an internal epitope of MRP3. Species Crossreactivity: human. Does not crossreact with human MDR1, MRP1, MRP2 or MRP5 gene products.
 Purity/Purification    Supernatant
Supernatant
 Form/Format    Supplied as a liquid, 0.7% BSA, 0.1% sodium azide.
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 Immunogen    Bacterial fusion protein corresponding to aa830-949 of MRP3.
 Hybridoma    Sp2/0 myeloma cells with lymph node cells from Balb/c mice.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ABCC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABCC3 antibody

   MRP3 is a 190-200kD transmembrane protein that is closely related to the multidrug resistance protein MRP1. M4688-23B has potential vaule for the detection of MRP3-mediated drug-resistance in human tumor samples.
 Product Categories/Family for anti-ABCC3 antibody    Antibodies; Abs to Multi Drug Resistance (MDR)
 Applications Tested/Suitable for anti-ABCC3 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

 Application Notes for anti-ABCC3 antibody    Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Flow Cytometry.
Dilution: Western Blot: 1:20-1:50 using a secondary antibody conjugated to HRP.
Immnocytochemistry: 1:20-1:50 on acetone or formaldehyde fixed cytospin preparations.
Immunohistochemistry (Frozen): 1:20 on acetone fixed frozen sections.
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 Test Data of anti-ABCC3 antibody    anti-ABCC3 antibody Test Data image
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NCBI/Uniprot data below describe general gene information for ABCC3. It may not necessarily be applicable to this product.
 NCBI GI #    4102188
 NCBI GeneID    8714
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 UniProt Primary Accession #    O15438 [Other Products]
 UniProt Secondary Accession #    O60265; O60922; O75621; O95078; O95289; O95290; Q86X85; Q9UN52; B2RPA9; D3DTX9 [Other Products]
 UniProt Related Accession #    O15438; Q2M3C9; Q59H05; Q86VN9; Q96QA9 [Other Products]
 Molecular Weight    169,343 Da [Similar Products]
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 NCBI Official Full Name    MRP3
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family C (CFTR/MRP), member 3
 NCBI Official Symbol    ABCC3 [Similar Products]
 NCBI Official Synonym Symbols   
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757; DKFZp686E22157
[Similar Products]
 NCBI Protein Information    canalicular multispecific organic anion transporter 2; OTTHUMP00000221667; OTTHUMP00000221668; OTTHUMP00000221670; multidrug resistance associated protein; multidrug resistance-associated protein 3; ATP-binding cassette sub-family C member 3; multi-specific organic anion transporter D; canicular multispecific organic anion transporter
 UniProt Protein Name    Canalicular multispecific organic anion transporter 2
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3
 Protein Family    ABC transporter C family
 UniProt Gene Name    ABCC3 [Similar Products]
 UniProt Synonym Gene Names    CMOAT2; MLP2; MRP3 [Similar Products]
 UniProt Entry Name    MRP3_HUMAN
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 NCBI Summary for ABCC3    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]
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 UniProt Comments for ABCC3    ABCC3: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: bile acid and bile salt transport; transport; bile acid metabolic process; transmembrane transport
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 Research Articles on ABCC3    1. Used a spin-labeled ATP analog, SL-ATP, to study nucleotide binding to highly purified human multidrug resistance protein 3, MRP3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ABCC3 antibodyDiseases associated with anti-ABCC3 antibody
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Recycling Of Bile Acids And Salts Pathway antibodies  Recycling Of Bile Acids And Salts Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >29 publications with ABCC3 and Neoplasms
 Liver Diseases Antibodies  >13 publications with ABCC3 and Liver Diseases
 Carcinoma Antibodies  >12 publications with ABCC3 and Carcinoma
 Drug Toxicity Antibodies  >11 publications with ABCC3 and Drug Toxicity
 Cholestasis Antibodies  >8 publications with ABCC3 and Cholestasis
 Liver Neoplasms Antibodies  >8 publications with ABCC3 and Liver Neoplasms
 Skin Diseases Antibodies  >7 publications with ABCC3 and Skin Diseases
 Adenocarcinoma Antibodies  >7 publications with ABCC3 and Adenocarcinoma
 Inflammation Antibodies  >5 publications with ABCC3 and Inflammation
 Lung Diseases Antibodies  >5 publications with ABCC3 and Lung Diseases
Organs/Tissues associated with anti-ABCC3 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >48 publications with ABCC3 and Liver
 Blood Antibodies  >37 publications with ABCC3 and Blood
 Intestine Antibodies  >14 publications with ABCC3 and Intestine
 Kidney Antibodies  >9 publications with ABCC3 and Kidney
 Lung Antibodies  >8 publications with ABCC3 and Lung
 Brain Antibodies  >5 publications with ABCC3 and Brain
 Vascular Antibodies  >4 publications with ABCC3 and Vascular
 Connective Tissue Antibodies  >2 publications with ABCC3 and Connective Tissue
 Bone Antibodies  >2 publications with ABCC3 and Bone
 Eye Antibodies  >1 publications with ABCC3 and Eye
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