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anti-MSH6 antibody :: Rabbit anti-Human, Mouse MSH6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8534531 anti-MSH6 antibody
Unit / Price
0.1 mL  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MSH6, Monoclonal Antibody

 Also Known As   

MSH6

 Product Synonym Names    DNA mismatch repair protein Msh6; G/T mismatch-binding protein; MutS protein homolog 6; MutS-alpha 160 kDa subunit
 Product Gene Name   

anti-MSH6 antibody

[Similar Products]
 Product Synonym Gene Name    hMSH6; GTBP; GTMBP; p160; MSH6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114500
 3D Structure    ModBase 3D Structure for P52701
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    JA84-26
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    ProA affinity purified
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 Immunogen    Recombinant Protein
 Storage Buffer    1*TBS (pH7.4), 1% BSA, 40% Glycerol.
 Preservative    0.116% Sodium Azide.
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 Preparation and Storage    Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-MSH6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MSH6 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for MSH6. It may not necessarily be applicable to this product.
 NCBI GI #    4504191
 NCBI GeneID    2956
 NCBI Accession #    NP_000170.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000179.2 [Other Products]
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 UniProt Primary Accession #    P52701 [Other Products]
 UniProt Secondary Accession #    O43706; O43917; Q8TCX4; Q9BTB5; B4DF41; B4E3I4; F5H2F9 [Other Products]
 UniProt Related Accession #    P52701 [Other Products]
 Molecular Weight    119,796 Da
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 NCBI Official Full Name    DNA mismatch repair protein Msh6 isoform 1
 NCBI Official Synonym Full Names    mutS homolog 6
 NCBI Official Symbol    MSH6 [Similar Products]
 NCBI Official Synonym Symbols   
GTBP; HSAP; p160; GTMBP; HNPCC5
[Similar Products]
 NCBI Protein Information    DNA mismatch repair protein Msh6
 UniProt Protein Name    DNA mismatch repair protein Msh6
 UniProt Synonym Protein Names   
G/T mismatch-binding protein
 Protein Family    DNA mismatch repair protein
 UniProt Gene Name    MSH6 [Similar Products]
 UniProt Synonym Gene Names    p160 [Similar Products]
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 NCBI Summary for MSH6    This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
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 UniProt Comments for MSH6    Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
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 Research Articles on MSH6    1. Our results suggest that increased expression of MSH6, or other MMR, may be a new mechanism contributing to the acquired resistance during TMZ therapy; and may serve as an indicator to the resistance in GBM.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MSH6 antibodyPathways associated with anti-MSH6 antibody
 Reference Product  PubMed Publications
 MSH2 antibody  >827 publications with MSH6 and MSH2
 MLH1 antibody  >641 publications with MSH6 and MLH1
 PMS2 antibody  >335 publications with MSH6 and PMS2
 PMS1 antibody  >78 publications with MSH6 and PMS1
 BRCA1 antibody  >39 publications with MSH6 and BRCA1
 PCNA antibody  >31 publications with MSH6 and PCNA
 TP53 antibody  >21 publications with MSH6 and TP53
 MUTYH antibody  >16 publications with MSH6 and MUTYH
 PRKDC antibody  >3 publications with MSH6 and PRKDC
 Products by Pathway  Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Cancer Pathway antibodies  Integrated Cancer Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Mismatch Repair Pathway antibodies  Mismatch Repair Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
Diseases associated with anti-MSH6 antibodyOrgans/Tissues associated with anti-MSH6 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >659 publications with MSH6 and Neoplasms
 Intestinal Neoplasms Antibodies  >480 publications with MSH6 and Intestinal Neoplasms
 Colorectal Neoplasms, Hereditary Nonpolyposis Antibodies  >384 publications with MSH6 and Colorectal Neoplasms, Hereditary Nonpolyposis
 Endometrial Neoplasms Antibodies  >159 publications with MSH6 and Endometrial Neoplasms
 Ovarian Neoplasms Antibodies  >55 publications with MSH6 and Ovarian Neoplasms
 Breast Neoplasms Antibodies  >54 publications with MSH6 and Breast Neoplasms
 Adenoma Antibodies  >50 publications with MSH6 and Adenoma
 Skin Neoplasms Antibodies  >39 publications with MSH6 and Skin Neoplasms
 Lymphoma Antibodies  >34 publications with MSH6 and Lymphoma
 Neoplasms, Experimental Antibodies  >28 publications with MSH6 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >68 publications with MSH6 and Blood
 Brain Antibodies  >49 publications with MSH6 and Brain
 Intestine Antibodies  >36 publications with MSH6 and Intestine
 Skin Antibodies  >36 publications with MSH6 and Skin
 Stomach Antibodies  >27 publications with MSH6 and Stomach
 Kidney Antibodies  >21 publications with MSH6 and Kidney
 Liver Antibodies  >19 publications with MSH6 and Liver
 Bladder Antibodies  >17 publications with MSH6 and Bladder
 Lymph Node Antibodies  >15 publications with MSH6 and Lymph Node
 Ovary Antibodies  >14 publications with MSH6 and Ovary
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