AAH12417.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
MTHFS protein, partial
NCBI Official Synonym Full Names
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
NCBI Official Synonym Symbols
NCBI Protein Information
5-formyltetrahydrofolate cyclo-ligase; methenyl-THF synthetase
UniProt Protein Name
5-formyltetrahydrofolate cyclo-ligase
UniProt Synonym Protein Names
5,10-methenyl-tetrahydrofolate synthetase
UniProt Synonym Gene Names
UniProt Entry Name
MTHFS_HUMAN
NCBI Summary for MTHFS
The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
UniProt Comments for MTHFS
Function: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
Catalytic activity: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.
Cofactor: Magnesium.
Subunit structure: Monomer.
Subcellular location: Cytoplasm.
Sequence similarities: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
Sequence caution: The sequence CK002935 differs from that shown. Reason: Frameshift at positions 178 and 201.
Research Articles on MTHFS
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-MTHFS antibody
Pathways associated with anti-MTHFS antibody
Organs/Tissues associated with anti-MTHFS antibody
|