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anti-MUC1 antibody :: anti-Human MUC1 (CD227) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS570198 anti-MUC1 antibody
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MUC1 (CD227), Monoclonal Antibody

 Also Known As   

Mouse anti MUC1 (CD227)

 Product Gene Name   

anti-MUC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (155158300..155162768, complement). Location: 1q21
 OMIM    113720
 3D Structure    ModBase 3D Structure for P15941
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    139H2
 Host    Mouse (Balb/c)
 Species Reactivity    Human
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 Specificity    Mouse monoclonal antibody has been raised anti Human milk-fat globule membranes (HMFGM) to obtain reagents for mammary tumor diagnosis. This monoclonal reacts towards an peptide epitope in the repeat region of MUC-1.
 Form/Format    Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
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 Source Note    The 139H2 monoclonal antibody is derived by immunisation of Balb/c mice with Human milk-fat globule membranes (HMFGM).
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 Preparation and Storage    Store at 4 degree C, or in small aliquots at -20 degree C.
 Other Notes    Small volumes of anti-MUC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MUC1 antibody

   Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in Humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs.The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity.Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.
 Product Categories/Family for anti-MUC1 antibody    CD markers, Cell adhesion, Cancer, Cell adhesion
 Applications Tested/Suitable for anti-MUC1 antibody   

Electron microscopy, ELISA (EIA), Flow Cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) (frozen), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-MUC1 antibody    139 H2 is useful for ELISA, immunofluorescence, flow cytometry, immunoprecipitation, western blot, electron microscopy and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titRation.
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NCBI/Uniprot data below describe general gene information for MUC1. It may not necessarily be applicable to this product.
 NCBI GI #    67189069
 NCBI GeneID    4582
 NCBI Accession #    NP_001018017.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018017.2 [Other Products]
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 UniProt Primary Accession #    P15941 [Other Products]
 UniProt Secondary Accession #    P13931; P15942; P17626; Q0VAP5; A5YRV1; A6ZID9; B1AVQ8; B1AVR0; B6ECA1; E7ESE5; E7EUG9 [Other Products]
 UniProt Related Accession #    P15941 [Other Products]
 Molecular Weight    122,102 Da [Similar Products]
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 NCBI Official Full Name    mucin-1 isoform 3
 NCBI Official Synonym Full Names    mucin 1, cell surface associated
 NCBI Official Symbol    MUC1 [Similar Products]
 NCBI Official Synonym Symbols   
EMA; PEM; PUM; KL-6; MAM6; PEMT; CD227; H23AG; MCKD1; MUC-1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC
[Similar Products]
 NCBI Protein Information    mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen
 UniProt Protein Name    Mucin-1
 UniProt Synonym Protein Names   
Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD_antigen: CD227Cleaved into the following 2 chains:Mucin-1 subunit alpha; MUC1-NT; MUC1-alpha; Mucin-1 subunit beta; MUC1-betaAlternative name(s):MUC1-CT
 Protein Family    Mucin
 UniProt Gene Name    MUC1 [Similar Products]
 UniProt Synonym Gene Names    PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta [Similar Products]
 UniProt Entry Name    MUC1_HUMAN
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 NCBI Summary for MUC1    This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
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 UniProt Comments for MUC1    MUC1: a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Nuclear receptor co-regulator; Membrane protein, integral; Tumor suppressor; Actin-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; cell surface; integral to plasma membrane; Golgi lumen; apical plasma membrane; cytoplasm; nuclear chromatin; vesicle

Molecular Function: protein binding; p53 binding; transcription cofactor activity

Biological Process: protein amino acid O-linked glycosylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; cellular protein metabolic process; regulation of transcription from RNA polymerase II promoter in response to stress; O-glycan processing; post-translational protein modification; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Disease: Medullary Cystic Kidney Disease 1
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Product References and Citations for anti-MUC1 antibody

   Hilkens J, Buijs F, Hilgers J, Hageman P, Calafat J, Sonnenberg A, van der Valk M. Monoclonal antibodies anti Human milk-fat globule membranes detecting differentiation antigens of the mammary gland and its tumors.
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 Research Articles on MUC1    1. The expression of mucin 1, cell surface associated (MUC1) and mucin 16, cell surface associated (MUC16) proteins and messenger ribonucleic acid (mRNA) in a cohort of postmenopausal women, was quantified.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MUC1 antibodyDiseases associated with anti-MUC1 antibody
 Products by Pathway  Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Termination Of O-glycan Biosynthesis Pathway antibodies  Termination Of O-glycan Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1774 publications with MUC1 and Neoplasms
 Breast Neoplasms Antibodies  >564 publications with MUC1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >188 publications with MUC1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >163 publications with MUC1 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >155 publications with MUC1 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >146 publications with MUC1 and Disease Models, Animal
 Inflammation Antibodies  >106 publications with MUC1 and Inflammation
 Necrosis Antibodies  >100 publications with MUC1 and Necrosis
 Liver Neoplasms Antibodies  >93 publications with MUC1 and Liver Neoplasms
 Liver Diseases Antibodies  >70 publications with MUC1 and Liver Diseases
Organs/Tissues associated with anti-MUC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >473 publications with MUC1 and Lung
 Stomach Antibodies  >195 publications with MUC1 and Stomach
 Pancreas Antibodies  >183 publications with MUC1 and Pancreas
 Liver Antibodies  >161 publications with MUC1 and Liver
 Intestine Antibodies  >141 publications with MUC1 and Intestine
 Eye Antibodies  >95 publications with MUC1 and Eye
 Prostate Antibodies  >87 publications with MUC1 and Prostate
 Kidney Antibodies  >81 publications with MUC1 and Kidney
 Uterus Antibodies  >69 publications with MUC1 and Uterus
 Ovary Antibodies  >55 publications with MUC1 and Ovary
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