CAA56734.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,297 Da
NCBI Official Full Name
MUC1
NCBI Official Synonym Full Names
mucin 1, cell surface associated
NCBI Official Synonym Symbols
EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC [Similar Products]
NCBI Protein Information
mucin-1
UniProt Protein Name
Mucin-1
UniProt Synonym Protein Names
Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3
UniProt Synonym Gene Names
PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta [Similar Products]
NCBI Summary for MUC1
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
UniProt Comments for MUC1
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
Product References and Citations for MUC1 recombinant antibody
Taylor-Papadimitriou Int J Cancer. 1981 Jul 15;28(1):17-21. PMID:7309278
Research Articles on MUC1
Precautions
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Products associated with MUC1 recombinant antibody
Pathways associated with MUC1 recombinant antibody
Diseases associated with MUC1 recombinant antibody
Organs/Tissues associated with MUC1 recombinant antibody
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