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anti-MUC16 antibody :: Mouse anti-Human MUC16 / CA125 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245325
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MUC16 / CA125, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone X306] (IgG1) to Human MUC16 / CA125

 Product Synonym Names    Anti-MUC16 / CA125 Antibody (clone X306) IHC-plus; MUC16; CA125 ovarian cancer antigen; CA125; CA-125; MUC-16; Mucin-16; Human MUC16; CA125
 Product Gene Name   

anti-MUC16 antibody

[Similar Products]
 Product Synonym Gene Name    CA125 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606154
 3D Structure    ModBase 3D Structure for Q8WXI7
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    X306
 Host    Mouse
 Species Reactivity    Human
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 Specificity    CA125 was concluded by the International Society of Oncology and BioMarkers (ISOBM) to contain two major antigenic domains. Recognizes the epitope specificity group A, similar to the OC125 antibody. Not suitable for conjugation to HRP
 Purity/Purification    Ion exchange Chromatography
 Form/Format    Tris buffered saline, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    CA125 antigen purified from human ovarian carcinoma.
 Immunogen    MUC16 / CA125 antibody was raised against cA125 antigen purified from human ovarian carcinoma.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-MUC16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MUC16 antibody

   Also commonly known as Ovarian Cancer Antigen CA-125.
 Applications Tested/Suitable for anti-MUC16 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MUC16 antibody    ELISA, IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: Validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides...
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 Immunohistochemistry (IHC) of anti-MUC16 antibody    Anti-MUC16 / CA-125 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MUC16 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MUC16. It may not necessarily be applicable to this product.
 NCBI GI #    83367077
 NCBI GeneID    94025
 NCBI Accession #    NP_078966.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_024690.2 [Other Products]
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 UniProt Primary Accession #    Q8WXI7 [Other Products]
 UniProt Secondary Accession #    Q6ZQW5; Q96RK2 [Other Products]
 UniProt Related Accession #    Q8WXI7 [Other Products]
 Molecular Weight    2,353,428 Da
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 NCBI Official Full Name    mucin-16
 NCBI Official Synonym Full Names    mucin 16, cell surface associated
 NCBI Official Symbol    MUC16 [Similar Products]
 NCBI Official Synonym Symbols   
CA125
[Similar Products]
 NCBI Protein Information    mucin-16; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125
 UniProt Protein Name    Mucin-16
 UniProt Synonym Protein Names   
Ovarian cancer-related tumor marker CA125; CA-125; Ovarian carcinoma antigen CA125
 Protein Family    Mucin
 UniProt Gene Name    MUC16 [Similar Products]
 UniProt Synonym Gene Names    CA125; MUC-16; CA-125 [Similar Products]
 UniProt Entry Name    MUC16_HUMAN
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 UniProt Comments for MUC16    MUC16: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; extrinsic to membrane; Golgi lumen; integral to membrane; plasma membrane; vesicle

Molecular Function: protein binding

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; post-translational protein modification; cell adhesion
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 Research Articles on MUC16    1. The modified cutoff value of CA125, HE4, RMI score and ROMA were 165.2 U/mL, 103.4 pM, 368.7, 28/54.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MUC16 antibodyPathways associated with anti-MUC16 antibody
 Reference Product  PubMed Publications
 MUC1 antibody  >82 publications with MUC16 and MUC1
 MUC2 antibody  >18 publications with MUC16 and MUC2
 MUC7 antibody  >10 publications with MUC16 and MUC7
 MUC13 antibody  >10 publications with MUC16 and MUC13
 MUC20 antibody  >7 publications with MUC16 and MUC20
 MUC15 antibody  >7 publications with MUC16 and MUC15
 LGALS1 antibody  >3 publications with MUC16 and LGALS1
 MSLN antibody  >3 publications with MUC16 and MSLN
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Termination Of O-glycan Biosynthesis Pathway antibodies  Termination Of O-glycan Biosynthesis Pathway Diagram
Diseases associated with anti-MUC16 antibodyOrgans/Tissues associated with anti-MUC16 antibody
 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >205 publications with MUC16 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >68 publications with MUC16 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >24 publications with MUC16 and Neoplasm Metastasis
 Inflammation Antibodies  >15 publications with MUC16 and Inflammation
 Gastrointestinal Diseases Antibodies  >15 publications with MUC16 and Gastrointestinal Diseases
 Lung Diseases Antibodies  >14 publications with MUC16 and Lung Diseases
 Skin Diseases Antibodies  >13 publications with MUC16 and Skin Diseases
 Cardiovascular Diseases Antibodies  >11 publications with MUC16 and Cardiovascular Diseases
 Heart Diseases Antibodies  >11 publications with MUC16 and Heart Diseases
 Necrosis Antibodies  >10 publications with MUC16 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >214 publications with MUC16 and Blood
 Eye Antibodies  >56 publications with MUC16 and Eye
 Lung Antibodies  >33 publications with MUC16 and Lung
 Ovary Antibodies  >29 publications with MUC16 and Ovary
 Lymph Node Antibodies  >24 publications with MUC16 and Lymph Node
 Epididymis Antibodies  >14 publications with MUC16 and Epididymis
 Uterus Antibodies  >14 publications with MUC16 and Uterus
 Pancreas Antibodies  >7 publications with MUC16 and Pancreas
 Intestine Antibodies  >7 publications with MUC16 and Intestine
 Cervix Antibodies  >6 publications with MUC16 and Cervix
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