Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow MUC5AC rightarrow Monoclonal MUC5AC  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • c-Fos ELISA Kit
 • nuclear receptor subfamily 3, group C, member 2 (NR3C2) ELISA Kit
 • CHK1 Antibody
 • CD206 Antibody
 • Hyaluronan and proteoglycan link protein 1 (HAPLN1) Recombinant Protein
 • 2-amino-3-carboxymuconate-6 -semialdehyde decarboxylase (ACMS... ELISA Kit
 • Amyloid beta peptide 1-42 (Abeta1-42) ELISA Kit
 • Rab7a Antibody
 • CD90 (Thy 1.1) (CD90 (Thy 1.1)) Antibody
 • IL-10 (IL10) ELISA Kit
 • SPHK2 Antibody
 • Zika Virus IgG (ZV-IgG) ELISA Kit
 • beta Lactoglobulin (beta -Lg) ELISA Kit
 • AIP ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-MUC5AC antibody :: Mouse anti-Human MUC5AC (Mucin 5AC / Gastric Mucin) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439594
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MUC5AC (Mucin 5AC / Gastric Mucin), Monoclonal Antibody

★Popular Item★
 Also Known As   

MUC5AC (Mucin 5AC / Gastric Mucin) Mouse Monoclonal Antibody

 Product Synonym Names    Apomucin Major Airway Glycoprotein, Mucin 5 subtype AC tracheobronchial, Mucin 5 Subtypes A And C, Mucin 5AC oligomeric mucus/gel forming, Tracheobronchial Mucin (TBM)
 Product Gene Name   

anti-MUC5AC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    158373
 3D Structure    ModBase 3D Structure for P98088
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    SPM488
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Specificity    Mucin 5AC glycoprotein (MUC5AC) is a HMW glycoprotein belonging to the superfamily of mucins. Mucins are produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC5AC is a mucus-forming, secreted mucin that is found in normal gastric and tracheo-bronchial mucosa, but absent from normal colon. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Section Bar
 Cellular Localization    Cytoplasmic
 Immunogen    A synthetic peptide of human MUC5AC tandem repeat
 Hu-Chromosome Location    11p15.5
 Positive Control    Stomach
Section Bar
 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-MUC5AC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-MUC5AC antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-MUC5AC antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Section Bar
 Immunohistochemistry (IHC) of anti-MUC5AC antibody    Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Monoclonal Antibody (SPM488).
anti-MUC5AC antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for MUC5AC. It may not necessarily be applicable to this product.
 NCBI GI #    748983076
 NCBI GeneID    4586
 NCBI Accession #    NP_001291288.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001304359.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P98088 [Other Products]
 UniProt Secondary Accession #    O60460; O76065; Q13792; Q14425; Q658Q1; Q7M4S5; Q8N4M9; Q8WWQ3; Q8WWQ4; Q8WWQ5; A0A096LPK4 [Other Products]
 UniProt Related Accession #    P98088 [Other Products]
 Molecular Weight    >1; 000kDa
Table BarTOPTable Bar
 NCBI Official Full Name    mucin-5AC
 NCBI Official Synonym Full Names    mucin 5AC, oligomeric mucus/gel-forming
 NCBI Official Symbol    MUC5AC [Similar Products]
 NCBI Official Synonym Symbols   
TBM; leB; MUC5; mucin
[Similar Products]
 NCBI Protein Information    mucin-5AC
 UniProt Protein Name    Mucin-5AC
 UniProt Synonym Protein Names   
Gastric mucin
 Protein Family    Mucin
 UniProt Gene Name    MUC5AC [Similar Products]
 UniProt Synonym Gene Names    TBM [Similar Products]
 UniProt Entry Name    MUC5A_HUMAN
Section Bar
 UniProt Comments for MUC5AC    MUC5AC iso1:

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; extracellular space; fibril; Golgi lumen

Molecular Function: extracellular matrix structural constituent

Biological Process: fibril organization and biogenesis; O-glycan processing; phosphoinositide-mediated signaling
Table BarTOPTable Bar
 

Product References and Citations for anti-MUC5AC antibody

   Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, et al. Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody. Int J Cancer 1997;74:112-21.
Section Bar
 Research Articles on MUC5AC    1. Overexpression of MUC5AC has been described in idiopathic pulmonary fibrosis lungs. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201507-1322LE#.V2WAGNLrtNs
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-MUC5AC antibodyDiseases associated with anti-MUC5AC antibody
 Products by Pathway  Pathway Diagram
 Defective C1GALT1C1 Causes Tn Polyagglutination Syndrome (TNPS) Pathway antibodies  Defective C1GALT1C1 Causes Tn Polyagglutination Syndrome (TNPS) Pathway Diagram
 Defective GALNT12 Causes Colorectal Cancer 1 (CRCS1) Pathway antibodies  Defective GALNT12 Causes Colorectal Cancer 1 (CRCS1) Pathway Diagram
 Defective GALNT3 Causes Familial Hyperphosphatemic Tumoral Calcinosis (HFTC) Pathway antibodies  Defective GALNT3 Causes Familial Hyperphosphatemic Tumoral Calcinosis (HFTC) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With O-glycosylation Of Proteins Pathway antibodies  Diseases Associated With O-glycosylation Of Proteins Pathway Diagram
 Diseases Of Glycosylation Pathway antibodies  Diseases Of Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >389 publications with MUC5AC and Lung Diseases
 Inflammation Antibodies  >375 publications with MUC5AC and Inflammation
 Asthma Antibodies  >263 publications with MUC5AC and Asthma
 Metaplasia Antibodies  >250 publications with MUC5AC and Metaplasia
 Hypersensitivity Antibodies  >170 publications with MUC5AC and Hypersensitivity
 Hyperplasia Antibodies  >169 publications with MUC5AC and Hyperplasia
 Respiratory Hypersensitivity Antibodies  >154 publications with MUC5AC and Respiratory Hypersensitivity
 Necrosis Antibodies  >138 publications with MUC5AC and Necrosis
 Disease Models, Animal Antibodies  >127 publications with MUC5AC and Disease Models, Animal
 Fibrosis Antibodies  >119 publications with MUC5AC and Fibrosis
Organs/Tissues associated with anti-MUC5AC antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >521 publications with MUC5AC and Lung
 Intestine Antibodies  >368 publications with MUC5AC and Intestine
 Stomach Antibodies  >353 publications with MUC5AC and Stomach
 Eye Antibodies  >199 publications with MUC5AC and Eye
 Pancreas Antibodies  >121 publications with MUC5AC and Pancreas
 Mammary Gland Antibodies  >4 publications with MUC5AC and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with MUC5AC and Uncharacterized Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions