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anti-MYL2 antibody :: Mouse MYL2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245437
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYL2, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone AT3B2] (IgG2b,k) to Human MYL2

 Product Synonym Names    Anti-MYL2 Antibody (clone AT3B2) IHC-plus; MYL2; MLC2; Myosin light chain 2; MLC-2; RLC of myosin; CMH10; MLC-2v; Human MYL2
 Product Gene Name   

anti-MYL2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 608758
 3D Structure    ModBase 3D Structure for P10916
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    AT3B2
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    human MYL2 (1-166aa)
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.1% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant human MYL2 (1-166aa) purified from E Coli
 Immunogen Type    Recombinant protein
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-MYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MYL2 antibody

   MYL2 encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
 Applications Tested/Suitable for anti-MYL2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-MYL2 antibody    ELISA, IHC-P (5 ug/ml), WB (1:1000 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MYL2 antibody    Anti-MYL2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-MYL2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-MYL2 antibody    Western analysis of mouse liver extracts
anti-MYL2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for MYL2. It may not necessarily be applicable to this product.
 NCBI GI #    94981553
 NCBI GeneID    4633
 NCBI Accession #    NP_000423.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000432.3 [Other Products]
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 UniProt Primary Accession #    P10916 [Other Products]
 UniProt Secondary Accession #    Q16123 [Other Products]
 UniProt Related Accession #    P10916 [Other Products]
 Molecular Weight    18,789 Da
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 NCBI Official Full Name    myosin regulatory light chain 2, ventricular/cardiac muscle isoform
 NCBI Official Synonym Full Names    myosin, light chain 2, regulatory, cardiac, slow
 NCBI Official Symbol    MYL2 [Similar Products]
 NCBI Official Synonym Symbols   
MLC2; CMH10
[Similar Products]
 NCBI Protein Information    myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; RLC of myosin; myosin light chain 2; regulatory light chain of myosin; cardiac ventricular myosin light chain 2; slow cardiac myosin regulatory light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow
 UniProt Protein Name    Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
 Protein Family    Myosin regulatory
 UniProt Gene Name    MYL2 [Similar Products]
 UniProt Synonym Gene Names    MLC-2; MLC-2v [Similar Products]
 UniProt Entry Name    MLRV_HUMAN
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 NCBI Summary for MYL2    Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MYL2    MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Protein type: Contractile

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: sarcomere; cytoskeleton; myofibril; myosin complex; cytosol; A band; actin cytoskeleton

Molecular Function: actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding

Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; muscle filament sliding; cardiac muscle contraction; post-embryonic development

Disease: Cardiomyopathy, Familial Hypertrophic, 10
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 Research Articles on MYL2    1. Results suggest that Aurora B, but not Rho/MLCK (myosin-light-chain kinase) signaling, is essential for the localization of 2P-MRLC (myosin regulatory light chains) to the midzone in dividing HeLa cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYL2 antibodyPathways associated with anti-MYL2 antibody
 Reference Product  PubMed Publications
 MYH7 antibody  >32 publications with MYL2 and MYH7
 MYL3 antibody  >31 publications with MYL2 and MYL3
 TNNI3 antibody  >25 publications with MYL2 and TNNI3
 MYBPC3 antibody  >23 publications with MYL2 and MYBPC3
 TNNT2 antibody  >23 publications with MYL2 and TNNT2
 TPM1 antibody  >17 publications with MYL2 and TPM1
 TTN antibody  >4 publications with MYL2 and TTN
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-MYL2 antibodyOrgans/Tissues associated with anti-MYL2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >36 publications with MYL2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >34 publications with MYL2 and Heart Diseases
 Cardiomyopathy, Hypertrophic Antibodies  >28 publications with MYL2 and Cardiomyopathy, Hypertrophic
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >12 publications with MYL2 and Cardiomyopathy, Hypertrophic, Familial
 Hypertrophy Antibodies  >10 publications with MYL2 and Hypertrophy
 Hypertension Antibodies  >5 publications with MYL2 and Hypertension
 Cardiomegaly Antibodies  >5 publications with MYL2 and Cardiomegaly
 Cardiomyopathy, Familial Hypertrophic, 10 Antibodies  >4 publications with MYL2 and Cardiomyopathy, Familial Hypertrophic, 10
 Inflammation Antibodies  >2 publications with MYL2 and Inflammation
 Fibrosis Antibodies  >1 publications with MYL2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >39 publications with MYL2 and Muscle
 Heart Antibodies  >30 publications with MYL2 and Heart
 Embryonic Tissue Antibodies  >5 publications with MYL2 and Embryonic Tissue
 Bone Antibodies  >3 publications with MYL2 and Bone
 Vascular Antibodies  >2 publications with MYL2 and Vascular
 Nerve Antibodies  >2 publications with MYL2 and Nerve
 Lymph Node Antibodies  >1 publications with MYL2 and Lymph Node
 Eye Antibodies  >1 publications with MYL2 and Eye
 Mouth Antibodies  >1 publications with MYL2 and Mouth
 Lung Antibodies  >1 publications with MYL2 and Lung
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