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anti-MYST1 antibody :: Mouse anti-Human MYST1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120465
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MYST1, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human MYST1

 Product Synonym Names    Homo sapiens MYST histone acetyltransferase 1 (MYST1), transcript variant 1, mRNA.; MOF; KAT8; hMOF; FLJ14040
 Product Gene Name   

anti-MYST1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609912
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2603C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-MYST1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MYST1 antibody

   The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000 [PubMed 10786633]).[supplied by OMIM][NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-MYST1 antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-MYST1 antibody    Western blot analysis of immunized recombinant protein, using anti-MYST1 monoclonal antibody.
anti-MYST1 antibody Quality Control image
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 Quality Control #2 of anti-MYST1 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-MYST1 antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-MYST1 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-MYST1 mAb. [Lot No.2603C2a-1]
anti-MYST1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for MYST1. It may not necessarily be applicable to this product.
 NCBI GI #    226371635
 NCBI GeneID    84148
 NCBI Accession #    NP_115564.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032188 [Other Products]
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 UniProt Secondary Accession #    Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9HAC5; Q9NR35; A8K4Z1; G5E9P2 [Other Products]
 UniProt Related Accession #    Q9H7Z6 [Other Products]
 Molecular Weight    53,085 Da
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 NCBI Official Full Name    Homo sapiens K(lysine) acetyltransferase 8 (KAT8), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    K(lysine) acetyltransferase 8
 NCBI Official Symbol    KAT8 [Similar Products]
 NCBI Official Synonym Symbols   
MOF; hMOF; MYST1; ZC2HC8
[Similar Products]
 NCBI Protein Information    histone acetyltransferase KAT8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST-1; histone acetyltransferase MYST1; lysine acetyltransferase 8; ortholog of Drosophila males absent on the first (MOF); probable histone acetyltransferase MYST1
 UniProt Protein Name    Histone acetyltransferase KAT8
 UniProt Synonym Protein Names   
Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF
 UniProt Gene Name    KAT8 [Similar Products]
 UniProt Entry Name    KAT8_HUMAN
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 NCBI Summary for MYST1    This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for MYST1    MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Acetyltransferase; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; kinetochore; nuclear membrane; nucleus; histone acetyltransferase complex

Molecular Function: protein binding; enzyme binding; histone acetyltransferase activity; metal ion binding; acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); transcription factor binding; methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; regulation of autophagy; histone acetylation; negative regulation of transcription, DNA-dependent
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 Research Articles on MYST1    1. The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth by targeting the expression of SIRT6.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-MYST1 antibodyDiseases associated with anti-MYST1 antibody
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with MYST1 and Nervous System Diseases
 Skin Diseases Antibodies  >4 publications with MYST1 and Skin Diseases
 Lung Neoplasms Antibodies  >3 publications with MYST1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >3 publications with MYST1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >2 publications with MYST1 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >2 publications with MYST1 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >2 publications with MYST1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >2 publications with MYST1 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >1 publications with MYST1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >1 publications with MYST1 and Cardiovascular Diseases
Organs/Tissues associated with anti-MYST1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with MYST1 and Lung
 Prostate Antibodies  >3 publications with MYST1 and Prostate
 Embryonic Tissue Antibodies  >3 publications with MYST1 and Embryonic Tissue
 Brain Antibodies  >3 publications with MYST1 and Brain
 Kidney Antibodies  >2 publications with MYST1 and Kidney
 Muscle Antibodies  >2 publications with MYST1 and Muscle
 Liver Antibodies  >2 publications with MYST1 and Liver
 Heart Antibodies  >1 publications with MYST1 and Heart
 Testis Antibodies  >1 publications with MYST1 and Testis
 Stomach Antibodies  >1 publications with MYST1 and Stomach
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