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| Product Name
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MYST1, Monoclonal Antibody
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| Also Known As
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Mouse monoclonal antibody Anti-Human MYST1
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| Product Synonym Names
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Homo sapiens MYST histone acetyltransferase 1 (MYST1), transcript variant 1, mRNA.; MOF; KAT8; hMOF; FLJ14040
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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609912
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| Clonality
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Monoclonal
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| Isotype
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IgG1
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| Clone Number
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2603C2a
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| Host
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Mouse
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| Species Reactivity
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Human
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| Concentration
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100 ug/ml (1.0 ml) (lot specific)
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| Preparation
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This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
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| Sterility
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Filtered through a 0.22 um membrane.
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| Other Notes
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Small volumes of anti-MYST1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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The MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000 [PubMed 10786633]).[supplied by OMIM][NCBI Entrez Gene Summary]
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| Applications Tested/Suitable for anti-MYST1 antibody
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Dot Blot (DB), Immunocytochemistry (ICC)
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| Quality Control of anti-MYST1 antibody
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Western blot analysis of immunized recombinant protein, using anti-MYST1 monoclonal antibody.
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| Quality Control #2 of anti-MYST1 antibody
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Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
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| Immunocytochemistry (ICC) of anti-MYST1 antibody
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Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-MYST1 mAb. [Lot No.2603C2a-1]
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| NCBI/Uniprot data below describe general gene information for MYST1. It may not necessarily be applicable to this product. |
| NCBI GI #
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226371635
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| NCBI GeneID
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84148
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| NCBI Accession #
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NP_115564.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_032188
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[Other Products]
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| UniProt Secondary Accession #
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Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9HAC5; Q9NR35; A8K4Z1; G5E9P2
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[Other Products]
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| UniProt Related Accession #
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Q9H7Z6
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[Other Products]
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| Molecular Weight
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53,085 Da
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TOP
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| NCBI Official Full Name
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Homo sapiens K(lysine) acetyltransferase 8 (KAT8), transcript variant 1, mRNA
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| NCBI Official Synonym Full Names
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K(lysine) acetyltransferase 8
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| NCBI Official Symbol
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KAT8
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[Similar Products]
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| NCBI Official Synonym Symbols
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MOF; hMOF; MYST1; ZC2HC8
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[Similar Products]
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| NCBI Protein Information
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histone acetyltransferase KAT8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST-1; histone acetyltransferase MYST1; lysine acetyltransferase 8; ortholog of Drosophila males absent on the first (MOF); probable histone acetyltransferase MYST1
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| UniProt Protein Name
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Histone acetyltransferase KAT8
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| UniProt Synonym Protein Names
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Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF
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| UniProt Gene Name
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KAT8
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[Similar Products]
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| UniProt Entry Name
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KAT8_HUMAN
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| NCBI Summary for MYST1
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This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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| UniProt Comments for MYST1
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MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Acetyltransferase; EC 2.3.1.48
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: nucleoplasm; kinetochore; nuclear membrane; nucleus; histone acetyltransferase complex
Molecular Function: protein binding; enzyme binding; histone acetyltransferase activity; metal ion binding; acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); transcription factor binding; methylated histone residue binding
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; regulation of autophagy; histone acetylation; negative regulation of transcription, DNA-dependent
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| Research Articles on MYST1
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1. The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth by targeting the expression of SIRT6.
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Pathways associated with anti-MYST1 antibody | Diseases associated with anti-MYST1 antibody |
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| Organs/Tissues associated with anti-MYST1 antibody |
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Antibody 
