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anti-MCP-1 antibody :: Mouse Macrophage/Monocyte Chemotactic & Activating Factor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140020 anti-MCP-1 antibody
Unit / Price
0.5 mg  /  $305 +1 FREE 8GB USB
1 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage/Monocyte Chemotactic & Activating Factor (MCP-1), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Macrophage/Monocyte Chemotactic & Activating Factor

 Product Synonym Names    MCP 1 Antibody; Macrophage/Monocyte Chemotactic & Activating Factor, Mouse Anti-Human; Small inducible cytokine A2; CCL2; Monocyte chemotactic protein 1; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte secretory protein JE; HC11; chemokine (C-C motif) ligand 2; MCP1; SCYA2; GDCF-2; SMC-CF; HSMCR30; MGC9434; GDCF-2 HC11
 Product Gene Name   

anti-MCP-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    158105
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    YNR-HMCAF
 Host    Mouse
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 Purity/Purification    Ion exchange.
 Concentration    1mg/ml in PBS (after reconstitution) Shipping ConditionsAntibody is shipped lyophilized at ambient temperature. (lot specific)
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 Reconstitution    Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
 Note    MCAF does not bind to plastic as good as most proteins - use higher concentration for proper binding.
 Immunogen    r.Human MCAF.
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 Preparation and Storage    In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-MCP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MCP-1 antibody

   Introduction: Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B (NF?B). CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weight of approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.
 Product Categories/Family for anti-MCP-1 antibody    MONOCLONAL ANTIBODIES, ANTI-HUMAN CHEMOKINES; Monoclonal Antibodies; Anti Human Chemokine
 Applications Tested/Suitable for anti-MCP-1 antibody   

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-MCP-1 antibody    Direct ELISA, Western Blot, Immunoprecipitation.
In direct ELISA, using alkaline phosphatase goat anti-mouse Ig (Jackson Laboratories) 1:5,000 dilution will give 0.3 O.D within 10 minutes.
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NCBI/Uniprot data below describe general gene information for MCP-1. It may not necessarily be applicable to this product.
 NCBI GI #    4506841
 NCBI GeneID    6347
 NCBI Accession #    NP_002973.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002982.3 [Other Products]
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 UniProt Secondary Accession #    Q9UDF3; B2R4V3 [Other Products]
 UniProt Related Accession #    P13500 [Other Products]
 Molecular Weight    11,025 Da
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 NCBI Official Full Name    C-C motif chemokine 2
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 2
 NCBI Official Symbol    CCL2 [Similar Products]
 NCBI Official Synonym Symbols   
HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 2; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; monocyte secretory protein JE; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small-inducible cytokine A2
 UniProt Protein Name    C-C motif chemokine 2
 UniProt Synonym Protein Names   
HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2
 Protein Family    Major capsid protein
 UniProt Gene Name    CCL2 [Similar Products]
 UniProt Synonym Gene Names    MCP1; SCYA2; MCAF; MCP-1 [Similar Products]
 UniProt Entry Name    CCL2_HUMAN
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 NCBI Summary for MCP-1    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
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 UniProt Comments for MCP-1    CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space; rough endoplasmic reticulum; endocytic vesicle; perinuclear region of cytoplasm; dendrite; extracellular region; synapse; perikaryon; nerve terminal

Molecular Function: heparin binding; CCR2 chemokine receptor binding; chemokine activity; receptor binding; protein kinase activity

Biological Process: maternal process involved in pregnancy; protein amino acid phosphorylation; response to antibiotic; monocyte chemotaxis; regulation of cell shape; cell surface receptor linked signal transduction; transforming growth factor beta receptor signaling pathway; response to vitamin B3; cellular homeostasis; negative regulation of neuron apoptosis; cell adhesion; neutrophil chemotaxis; organ regeneration; response to amino acid stimulus; positive regulation of tumor necrosis factor production; JAK-STAT cascade; G-protein signaling, coupled to cyclic nucleotide second messenger; organ morphogenesis; response to ethanol; unfolded protein response, activation of signaling protein activity; response to bacterium; cellular response to insulin stimulus; response to heat; response to mechanical stimulus; positive regulation of endothelial cell proliferation; response to activity; response to progesterone stimulus; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of collagen biosynthetic process; signal transduction; chemotaxis; positive regulation of synaptic transmission; positive regulation of cellular extravasation; protein kinase B signaling cascade; response to wounding; lipopolysaccharide-mediated signaling pathway; response to gamma radiation; angiogenesis; inflammatory response; lymphocyte chemotaxis; aging; unfolded protein response; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; cytoskeleton organization and biogenesis; viral genome replication; macrophage chemotaxis; leukocyte migration during inflammatory response; humoral immune response; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of leukocyte mediated cytotoxicity; cellular protein metabolic process; maternal process involved in parturition; response to hypoxia; positive regulation of T cell activation; vascular endothelial growth factor receptor signaling pathway; astrocyte cell migration

Disease: Neural Tube Defects; Mycobacterium Tuberculosis, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on MCP-1    1. In endometriosis, TSLP is involved in estrogen mediated regulation of the secretion of MCP-1 and IL-8, and the growth of endometrial stromal cells through JNK and NF-kappaB signal pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MCP-1 antibodyPathways associated with anti-MCP-1 antibody
 Reference Product  PubMed Publications
 CCR2 antibody  >1243 publications with MCP-1 and CCR2
 JUN antibody  >1183 publications with MCP-1 and JUN
 CCR5 antibody  >333 publications with MCP-1 and CCR5
 IL6 antibody  >279 publications with MCP-1 and IL6
 CCR1 antibody  >179 publications with MCP-1 and CCR1
 CXCR4 antibody  >150 publications with MCP-1 and CXCR4
 CX3CR1 antibody  >121 publications with MCP-1 and CX3CR1
 CCR3 antibody  >101 publications with MCP-1 and CCR3
 JAK2 antibody  >26 publications with MCP-1 and JAK2
 DARC antibody  >21 publications with MCP-1 and DARC
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Diseases associated with anti-MCP-1 antibodyOrgans/Tissues associated with anti-MCP-1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4450 publications with MCP-1 and Inflammation
 Necrosis Antibodies  >2591 publications with MCP-1 and Necrosis
 Cardiovascular Diseases Antibodies  >1868 publications with MCP-1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1043 publications with MCP-1 and Atherosclerosis
 Myocardial Ischemia Antibodies  >401 publications with MCP-1 and Myocardial Ischemia
 Liver Diseases Antibodies  >360 publications with MCP-1 and Liver Diseases
 Hypersensitivity Antibodies  >327 publications with MCP-1 and Hypersensitivity
 Glomerulonephritis Antibodies  >289 publications with MCP-1 and Glomerulonephritis
 Lung Injury Antibodies  >249 publications with MCP-1 and Lung Injury
 Asthma Antibodies  >211 publications with MCP-1 and Asthma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5726 publications with MCP-1 and Blood
 Vascular Antibodies  >2576 publications with MCP-1 and Vascular
 Kidney Antibodies  >1172 publications with MCP-1 and Kidney
 Lung Antibodies  >1097 publications with MCP-1 and Lung
 Muscle Antibodies  >1039 publications with MCP-1 and Muscle
 Brain Antibodies  >948 publications with MCP-1 and Brain
 Bone Antibodies  >726 publications with MCP-1 and Bone
 Liver Antibodies  >686 publications with MCP-1 and Liver
 Heart Antibodies  >663 publications with MCP-1 and Heart
 Bone Marrow Antibodies  >477 publications with MCP-1 and Bone Marrow
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