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anti-CXCL2 antibody :: Mouse anti-Human Macrophage inflammatory protein 2-alpha Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS607542 anti-CXCL2 antibody
Unit / Price
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage inflammatory protein 2-alpha (CXCL2), Monoclonal Antibody

 Also Known As   

Macrophage inflammatory protein 2-alpha (CXCL2, Chemokine (C-X-C motif) ligand 2, CINC-2a, GRO2, GROb, GROB, Gro-beta, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha precursor, MGSA-b, MGSA beta, MIP2, MIP2A, MIP-2a, MIP2-alpha, SC

 Product Synonym Names    Anti -Macrophage inflammatory protein 2-alpha (CXCL2, Chemokine (C-X-C motif) ligand 2, CINC-2a, GRO2, GROb, GROB, Gro-beta, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha precursor, MGSA-b, MGSA beta, MIP2, MIP2A, MIP-2a, MIP2-alpha, SC
 Product Gene Name   

anti-CXCL2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (74962752..74964997, complement). Location: 4q21
 OMIM    139110
 3D Structure    ModBase 3D Structure for P19875
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    1.A.12
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes recombinant human MIP2 alpha. Crossreacts with recombinant human-MIP2b and recombinant human-MIP-2a (ELISA). Does not crossreact with recombinant human-MIP1a or recombinant human-MIP1b.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in 0.1M Tris HCl, pH 7.5.
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 Immunogen    Recombinant human MIP-2a produced in genetically engineered yeast and purified by sequential chromatography.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-CXCL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CXCL2 antibody

   Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines.[CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
 Product Categories/Family for anti-CXCL2 antibody    Antibodies; Abs to Growth Factors, Cytokines
 Applications Tested/Suitable for anti-CXCL2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-CXCL2 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 10ug/ml
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NCBI/Uniprot data below describe general gene information for CXCL2. It may not necessarily be applicable to this product.
 NCBI GI #    2905630
 NCBI GeneID    2920
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 UniProt Primary Accession #    P19875 [Other Products]
 UniProt Secondary Accession #    Q6FGD6; Q9UPB8 [Other Products]
 UniProt Related Accession #    P19875; Q6LD33 [Other Products]
 Molecular Weight    11,389 Da [Similar Products]
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 NCBI Official Full Name    macrophage inflammatory protein 2 alpha
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 2
 NCBI Official Symbol    CXCL2 [Similar Products]
 NCBI Official Synonym Symbols   
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 2; gro-beta; MGSA beta; MIP2-alpha; GRO2 oncogene; OTTHUMP00000219185; growth-regulated protein beta; macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta
 UniProt Protein Name    C-X-C motif chemokine 2
 UniProt Synonym Protein Names   
Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alphaCleaved into the following chain:GRO-beta(5-73); Alternative name(s):; GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353
 Protein Family    C-X-C motif chemokine
 UniProt Gene Name    CXCL2 [Similar Products]
 UniProt Synonym Gene Names    GRO2; GROB; MIP2A; SCYB2 [Similar Products]
 UniProt Entry Name    CXCL2_HUMAN
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 NCBI Summary for CXCL2    This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
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 UniProt Comments for CXCL2    CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation
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 Research Articles on CXCL2    1. It can be hypothesized that for some targets, such as CXCL1 and CXCL2, additional signaling may be necessary to fully activate the 3'untranslated region-dependent human antigen R (HuR) function in airway epithelium
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXCL2 antibodyPathways associated with anti-CXCL2 antibody
 Reference Product  PubMed Publications
 CXCR2 antibody  >112 publications with CXCL2 and CXCR2
 CXCR1 antibody  >17 publications with CXCL2 and CXCR1
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-CXCL2 antibodyOrgans/Tissues associated with anti-CXCL2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >720 publications with CXCL2 and Inflammation
 Lung Diseases Antibodies  >299 publications with CXCL2 and Lung Diseases
 Lung Injury Antibodies  >212 publications with CXCL2 and Lung Injury
 Pneumonia Antibodies  >141 publications with CXCL2 and Pneumonia
 Cardiovascular Diseases Antibodies  >119 publications with CXCL2 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >116 publications with CXCL2 and Vascular Diseases
 Acute Lung Injury Antibodies  >110 publications with CXCL2 and Acute Lung Injury
 Drug Toxicity Antibodies  >108 publications with CXCL2 and Drug Toxicity
 Sepsis Antibodies  >99 publications with CXCL2 and Sepsis
 Neoplasms Antibodies  >70 publications with CXCL2 and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >802 publications with CXCL2 and Blood
 Lung Antibodies  >494 publications with CXCL2 and Lung
 Liver Antibodies  >146 publications with CXCL2 and Liver
 Bone Antibodies  >98 publications with CXCL2 and Bone
 Bone Marrow Antibodies  >87 publications with CXCL2 and Bone Marrow
 Brain Antibodies  >85 publications with CXCL2 and Brain
 Intestine Antibodies  >78 publications with CXCL2 and Intestine
 Kidney Antibodies  >74 publications with CXCL2 and Kidney
 Eye Antibodies  >43 publications with CXCL2 and Eye
 Lymph Node Antibodies  >30 publications with CXCL2 and Lymph Node
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