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anti-MSLN antibody :: Mouse anti-Human Megakaryocyte Potentiating Factor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS600295 anti-MSLN antibody
Unit / Price
0.1 mg  /  $645 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Megakaryocyte Potentiating Factor (MSLN), Monoclonal Antibody

★Popular Item★
 Also Known As   

Megakaryocyte Potentiating Factor (MPF)

 Product Synonym Names    Anti -Megakaryocyte Potentiating Factor (MPF)
 Product Gene Name   

anti-MSLN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (810765..818865). Location: 16p13.3
 OMIM    601051
 3D Structure    ModBase 3D Structure for Q13421
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    7H109
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human MPF.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 200ul sterile 40-50% glycerol, PBS.
 Concentration    ~0.5 mg/ml (after reconstitution) (lot specific)
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 Immunogen    Recombinant protein corresponding to aa35-289 from human MPF expressed in NS0 cells(Q13421)
  Accession #    Q13421
 Hybridoma    Myeloma cells with B cells with purified, NS0-derived, recombinant human CD27 Ligand (rhCD27 Ligand; Accession #NP_001243) extracellular domain.
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute with sterile 40-50% glycerol, PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-MSLN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MSLN antibody

   Megakaryocyte Potentiating Factor (MPF) is a 33kD soluble protein that is cleaved as an N-terminal propeptide from the mouse mesothelin preproprotein by furin, while the C-terminal portion is processed further to form mesothelin. Mouse MPF potentiates megakaryocyte colony forming activity of IL-3 in mouse bone marrow culture. Human MPF shows 55% amino acid identity with mouse or rat MPF. The preproprotein is produced by mesothelial cells and is also highly expressed in pancreatic, gastric and ovarian carcinomas.
 Product Categories/Family for anti-MSLN antibody    Antibodies; Abs to Proteins
 Applications Tested/Suitable for anti-MSLN antibody   

Direct ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-MSLN antibody    Dilution: Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for MSLN. It may not necessarily be applicable to this product.
 NCBI GI #    293651530
 NCBI GeneID    10232
 NCBI Accession #    NP_001170826.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001177355.1 [Other Products]
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 UniProt Primary Accession #    Q13421 [Other Products]
 UniProt Secondary Accession #    Q14859; Q4VQD5; Q96GR6; Q96KJ5; Q9BR17; Q9BTR2; Q9UCB2; Q9UK57; D3DU65 [Other Products]
 UniProt Related Accession #    Q13421 [Other Products]
 Molecular Weight    68,986 Da [Similar Products]
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 NCBI Official Full Name    mesothelin isoform 1 preproprotein
 NCBI Official Synonym Full Names    mesothelin
 NCBI Official Symbol    MSLN [Similar Products]
 NCBI Official Synonym Symbols   
MPF; SMRP
[Similar Products]
 NCBI Protein Information    mesothelin; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor
 UniProt Protein Name    Mesothelin
 UniProt Synonym Protein Names   
CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor
 Protein Family    Mesothelin
 UniProt Gene Name    MSLN [Similar Products]
 UniProt Synonym Gene Names    MPF; MPF [Similar Products]
 UniProt Entry Name    MSLN_HUMAN
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 NCBI Summary for MSLN    This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
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 UniProt Comments for MSLN    MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; plasma membrane

Molecular Function: protein binding

Biological Process: pancreas development; cell adhesion
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 Research Articles on MSLN    1. Data indicate that binding of mesothelin to CA125 does not alter the measurement of mesothelin for the detection of malignant mesothelioma (MM).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-MSLN antibodyOrgans/Tissues associated with anti-MSLN antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >41 publications with MSLN and Neoplasms
 Carcinoma Antibodies  >13 publications with MSLN and Carcinoma
 Mesothelioma Antibodies  >12 publications with MSLN and Mesothelioma
 Neoplasms, Mesothelial Antibodies  >11 publications with MSLN and Neoplasms, Mesothelial
 Adenocarcinoma Antibodies  >10 publications with MSLN and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >9 publications with MSLN and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >5 publications with MSLN and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with MSLN and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >4 publications with MSLN and Breast Neoplasms
 Liver Neoplasms Antibodies  >3 publications with MSLN and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with MSLN and Lung
 Liver Antibodies  >5 publications with MSLN and Liver
 Pancreas Antibodies  >3 publications with MSLN and Pancreas
 Ovary Antibodies  >3 publications with MSLN and Ovary
 Stomach Antibodies  >2 publications with MSLN and Stomach
 Ascites Antibodies  >1 publications with MSLN and Ascites
 Brain Antibodies  >1 publications with MSLN and Brain
 Intestine Antibodies  >1 publications with MSLN and Intestine
 Prostate Antibodies  >1 publications with MSLN and Prostate
 Cervix Antibodies  >1 publications with MSLN and Cervix
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